Daniela Hermelin, MD Profile picture
Jun 16, 2022 9 tweets 5 min read Read on X
Thank you for joining me to today for the @SSMHealthSTL Pediatric Education Webinar Series where we discussed the topic of 🩸👶🏾Pediatric Patient Blood Management.
From our rural hospitals to large academic ones, together let's optimize pediatric & neonatal care.
👇🏽 #Blooducation
Coming out of #WorldBloodDonorDay, it was perfect timing to discuss this topic as we celebrate our incredible blood donors while bringing awareness of the need to collect and transfuse safe blood to our patients, many which are so 🖐️🏽tiny, fitting within the palm of our hand.
💎Blood is a precious resource.
⚖️Blood transfusions have risks.
"Transfusing the right product, in the right dose, to the right patient, at the right time" is the fundamental concept of Patient Blood Management.
How do we apply these concepts within the pediatric setting?
🏃🏽‍♀️To get started, recruit hospital champions on a multidisciplinary level (clinical + administrative) to develop consensus goals.
Develop evidence based guidelines to establish hospital policy.
Monitor adherence.
Audit, audit, audit.
Did you accomplish a successful intervention?
Consider many strategies:
1) Blood conservation (reducing blood draws)
2) Restrictive transfusions (less is more)
3) Personalize transfusion/optimize coagulation
4) Autologous blood therapies (Bloodless medicine)
Need additional resources to develop and implement Patient Blood Management Programs, please check out @bloodmgmt phenomenal online publications:
sabm.org/publications/
Make sure to review these fantastic @aabb Patient Blood Management🧰 toolbox resources 👉🏽🩸aabb.org/news-resources…
Also, I highly recommend this outstanding Transfusion Medicine Reviews article by @ruchika_goel1, @cushing_melissa & @AaronTobian 👉🏽Pediatric Patient Blood Management Programs: Not Just Transfusing Little Adults sciencedirect.com/science/articl…
⁉️ Do you have experience developing Pediatric Patient Blood Management programs at your institution?
What areas have you focused on?
🙏🏽Thanks for you providing your insights below!

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More from @HermelinMD

Dec 17, 2024
#SLUSOMPath24
In our final week, we focused on #HemodynamicDisorders including #edema, hemostasis, infarction, thrombosis and shock. Let’s recap on these concepts and study for the exam 👇🏽Follow #Tweetorial below. Image
#Edema is a condition in which there is increased fluid in the interstitial extravascular space. Vascular hydrostatic pressure & plasma osmotic pressure are factors that control movement between vascular & interstitial spaces. How does a deep venous thrombus (#DVT) cause edema?
👍🏽You got it. A #DVT causes venous blockage, and therefore leads to increased hydrostatic pressure DISTAL to the site of the thrombus. This causes edema to the areas dependent on the blocked vein for drainage. Check out the symptoms of #DVT here👇🏽
Read 16 tweets
Dec 11, 2024
#SLUSOMPath24.
Week #2 Dr. Miller covered topics of Neoplasia.
Let's take a few minutes to review the material and study for the exam.
👇🏽Follow the #Tweetorial below. Image
Neoplasia can divided into benign and malignant processes.
⁉What is the main feature that can separate the two?
That's right. The main feature that distinguishes between benign + malignant is the potential to invade basement membrane + metastasize or spread through blood or lymphatics to distant sites.
👇🏽This fibrosarcoma has all the features of malignant.
Read 13 tweets
Dec 6, 2024
#SLUSOMPath24, 😀👏🏽Congratulations on completing your first week of Introduction to Pathology. Let's review some of the concepts you learned with Dr. Brink as you head into Week #2 and we begin to discuss #Neoplasia.
Follow the #Tweetorial below. Image
When a person develops chronic hypertension, strain can develop on the heart leading to an increase in mechanical work load. Cardiac myocytes (heart muscle fibers) grow in size to accommodate.
⁉️This cellular adaptive change is called?
🙌🏽You got it. Hypertrophy occurs when cells increase in their size which primarily occurs with myocytes. On the other hand, hyperplasia is when cells increase in number. Here’s an example of cardiac hypertrophy. Notice how thickened the cardiac walls and muscle fibers appear 👉🏽
Read 14 tweets
Jul 1, 2022
Spherocytes don’t jiggle jiggle, like normal biconcave RBCs b/c of defects in membrane proteins (ankyrin-1 band 3)

They are smaller in diameter, hyperchromic, & lack central pallor.

HS is the leading cause of Coombs-neg hemolytic anemia requiring transfusion in neonates.
To learn about testing for HS check out this great post by @AaronGoodman33 👇🏼👇🏼
💡💡And for even more learning, check out
@rabihmgeha diagnostic work up for #hereditaryspherocytosis 👇🏼👇🏼
Read 5 tweets
Mar 3, 2022
🌟Just released! Outstanding @bloodbankguy 🎧podcast w/ Dr. Sujit Sheth. Comprehensive discussion on transfusion-dependent #thalassemia focusing on pathogenesis, terminology & role of transfusion support. Listen now for CE credit.
For the pearls, follow the #Tweetorial below👇🏽
Derived from the Greek word “thal” or sea🌊thalassemia known as Mediterranean anemia, is an anemia affecting 1.5% of the world population along the “thalassemia belt” extending from the Mediterranean, the Middle East, India, SoutheastAsia, up to China. Like SCD, thalassemias are:
Thalassemias are also hereditary and may offer protection against malaria. However, unlike #sicklecelldisease which results in qualitative Hb defects, thalassemia causes a quantitative defects in either Hb α or β chains causing both ineffective erythropoiesis and anemia. Robbins & Cotran Pathologic...
Read 12 tweets
Nov 17, 2021
Thank you for joining me today to learn about how TEG6S can be utilized within #Anesthesiology. Let's recap on some of the topics that we learned such as specimen collection and transportation, test components, interpretations and more.
👇🏽Follow the #tweetorial below.
First, we reviewed concepts of hemostasis.
Imagine that you cut your hand on a sharp piece of glass, ouch😲
After vasoconstriction, endothelial injury leads to PLT adhesion & aggregation --> the PLT plug.
Release of tissue factor activates coagulation cascade -->fibrin clot
Although we learn these pathways as if they happen sequentially, they are really happening simultaneously. 🔄Platelets are activated by thrombin formation, thrombin formation is activated by platelets.
⁉️What are the traditional coag labs?
Read 11 tweets

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