Spherocytes don’t jiggle jiggle, like normal biconcave RBCs b/c of defects in membrane proteins (ankyrin-1 band 3)

They are smaller in diameter, hyperchromic, & lack central pallor.

HS is the leading cause of Coombs-neg hemolytic anemia requiring transfusion in neonates. To learn about testing for HS check out this great post by @AaronGoodman33 👇🏼👇🏼

https://twitter.com/aarongoodman33/status/1412068442719485956

Thank you for joining me to today for the @SSMHealthSTL Pediatric Education Webinar Series where we discussed the topic of 🩸👶🏾Pediatric Patient Blood Management.
From our rural hospitals to large academic ones, together let's optimize pediatric & neonatal care.
👇🏽 #Blooducation Coming out of #WorldBloodDonorDay, it was perfect timing to discuss this topic as we celebrate our incredible blood donors while bringing awareness of the need to collect and transfuse safe blood to our patients, many which are so 🖐️🏽tiny, fitting within the palm of our hand.

🌟Just released! Outstanding @bloodbankguy 🎧podcast w/ Dr. Sujit Sheth. Comprehensive discussion on transfusion-dependent #thalassemia focusing on pathogenesis, terminology & role of transfusion support. Listen now for CE credit.
For the pearls, follow the #Tweetorial below👇🏽

https://twitter.com/bloodbankguy/status/1499150971548561413

Derived from the Greek word “thal” or sea🌊thalassemia known as Mediterranean anemia, is an anemia affecting 1.5% of the world population along the “thalassemia belt” extending from the Mediterranean, the Middle East, India, SoutheastAsia, up to China. Like SCD, thalassemias are:

Thank you for joining me today to learn about how TEG6S can be utilized within #Anesthesiology. Let's recap on some of the topics that we learned such as specimen collection and transportation, test components, interpretations and more.
👇🏽Follow the #tweetorial below.

https://twitter.com/HermelinMD/status/1460801764517720067

First, we reviewed concepts of hemostasis.
Imagine that you cut your hand on a sharp piece of glass, ouch😲
After vasoconstriction, endothelial injury leads to PLT adhesion & aggregation --> the PLT plug.
Release of tissue factor activates coagulation cascade -->fibrin clot

🅰️🅱️🅾️🆎#Blooducation colleagues: Fantastic new @bloodbankguy 🎧podcast with Dr. Mark Yazer on the topic of Whole Blood in Trauma Resuscitation discussing benefits and safety, and review of many important published trials. Listen now --> BBGuy.org/091.

https://twitter.com/bloodbankguy/status/1400165159956451330

Dr. Yazer explains some major benefits of #wholeblood. Balanced resuscitation in just 👜ONE bag, making logistics so much easier. There are fewer donor exposures and less additives & anticoagulants. Additionally, cold stored platelets are "primed for coagulation activity"

A 1 day y/o 👶🏽neonate, born at 40 weeks, was transferred to our NICU for anemia & hyperbilirubinemia. He is jaundice but has no signs of encephalopathy.🩸The antibody screen is positive.
👇🏽Check out his peripheral smear below and notice the increased number of nucleated RBCs. 🤔Based on the peripheral smear findings, you begin to investigate the patient’s blood bank history because you are suspecting:

Listen now! #Blooducation Graphic Medicine @Pathologists virtual lecture with @KreuterMD
learn.cap.org/lms/activity_o… "My heart beats for patient collaboration and that's why I went in Transfusion Medicine...."

🤩I am constantly marveled by the endless ways in which we #Pathology and #LabMedicine, can use Twitter to engage, share, support & learn from each other. Here is the link to my presentation that celebrates the unlimited opportunities to harness Twitter👉🏽
bit.ly/39kA627

https://twitter.com/HermelinMD/status/1226891913472741376

Like the #SolarEclipse that occurred in August 2017, to me, Twitter has been a community wide experience of marveling a visual process that can create a burst of awe at an organic velocity. It's really exciting to be engaged in this global experience.

A 23-year-old woman w/ a history of SLE was admitted to the hospital w/ abdominal pain & headache. Purpura is seen on her chest & thighs. Hb /Hct= 8.3,28.4, PLT= 7,000, LDH = 952, Hapto = <8, Ind Bili = 1.2, Cr = 1.2 PT/INR = 1.3. 👇🏼Take a look at her peripheral smear. ⁉️Based on the initial lab results and the peripheral smear findings above, what is your differential? #PathTweetorial #Blooducation #ApheresisRounds

A 32-year-old man with HbS/βThalassemia presented to the ED with weakness in his left arm and slurred speech. His HbS is 71%. Take a look at his peripheral smear below, notice the drepanocytes, or sickle-shaped cells. Since you are the #BloodBank resident on-call, Heme/Onc requests urgent erythrocytaphereisis, otherwise known as #RedCellExchange. 🗣️You reply?

24 y/o w/ h/o of Crohn’s Disease presents w/ worsening fatigue, weakness & dizziness. He has mild abdominal pain, but no signs of bleeding. No transfusion history. Infliximab was discontinued for autoimmune hepatitis. Hb/Hct = 4.4/13.5. 👇🏽Check out his peripheral smear below. 🤨Since you are the Heme/Onc Fellow on-call, you are 📟paged to consult on this patient’s anemia. What are the first labs you would order to assess #hemolysis?
#Blooducation #BBRounds #PathTweetorial

Thursday #Blooducation schmooze on the topic of anti-G antibodies as they pertain to pregnancy and #HDFN. 👇🏽Follow the thread below to get capture the key points🅰️🅱️🆎🅾️🤰🏽👶🏽 Let's get started. #PathTweetorial 🚧The anti-G antibody can cause confusion because it presents on a panel as a combination of anti-D and anti-C, sometimes called "anti-CD", when truly, an anti-D may not be present at all 🤦🏽‍♀️
⁉️What type of patients can form an anti-G?

1/10
These are the lungs of a patient who died while receiving a PLT transfusion. He developed sudden respiratory distress and did not respond to O2 support. Lungs compressed by 3000 mL of transudative pleural fluid. Notice the increased neutrophils #PathTweetorial 2/10
The above clinical scenario along with the histologic findings is consistent with which type of transfusion reaction?
#Blooducation #TransfusionReaction

62 y/o man, O positive with de novo AML undergoes workup for Hematopoietic Stem Cell Transplant (HSCT). 😃Good news: Sibling with 8/8 HLA match! 👎🏽Bad news: Sibling is A positive. Can this sibling be a donor?
#Blooducation #PathTweetorial #HSCT Unlike solid organ transplants, ABO-mismatch HSCT is not a barrier. In fact, 25-50% of all HSCT are ABO-incompatible. The most important factor in transplant survival outcomes is HLA compatibility (Chrom. 6p)
✅Critical to engraftment
✅ Balances potential harm of GVHD vs GVL