Dave Feldman Profile picture
Jun 30 โ€ข 4 tweets โ€ข 2 min read
1/3 Okay, here's my daily breakdown for the #IsItSaturatedFat Experiment.

I'm going to consume 1,000 calories for @KerrygoldUSA! ๐Ÿงˆ๐Ÿงˆ๐Ÿงˆ

That's 140g of butter per day!
2/3 However, I'll be likewise supplementing 728 calories from dextrose, thus consuming much of my remaining dietary energy from carbs.

Per the #LEM, I believe this will have a substantial lowering impact on my LDL-C relative to the increasing influence via โฌ‡๏ธLDLr of butter
3/3 Note I'm performing this experiment in the spirit of both learning and keeping it fun. โ˜ฎ๏ธ

While I'll concede I might have been caught off guard for a moment yesterday, I'm now thankful this can provide us a new opportunity for discovery and furthering the discussion. ๐Ÿ”ฌ๐Ÿ”ฌ๐Ÿ”ฌ
Btw, big thanks to @ketochow for providing their delicious* product for this experiment.

(*Chris has agreed to tell me one "dad joke" for each time I say keto chow is delicious**)

(**Just kidding, he provides those for free as well)

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More from @realDaveFeldman

Jun 29
1/ ๐ŸšจNew N=1 Experiment: #IsItSaturatedFat๐Ÿšจ
๐Ÿ™retweet๐Ÿ™

Yes, I'm doing a new N=1 -- and it's going to be a biggie!

My good friend and colleague, @DrNadolsky completed his recent #MakingLMHR experiment concluding the added 2 sticks of butter as the reason for his LDL increase. Image
2/ He's already conceded he's left out all the context on aiming for #LMHR profile, the relevance of RER, and the #LEM (so no need for people to keep pinging me on the IG video). I've chatted with him privately and we'll leave it at that. ๐Ÿ‘

3/ However -- this actually affords us a huge new opportunity.

@DrNadolsky's claim isn't just his own, it's just about everyone else's outside the low carb community.

Simply stated: high #LDL #cholesterol seen in #LMHRs is predominantly due to high consumption of saturated fat.
Read 6 tweets
Jun 28
1/ I want to give huge props to @DrNadolsky for doing this #MakingLMHR experiment!

Yes, I know some of my followers may be blocked -- so I'm including an image as well.

If you're interested in how this experiment came about -- read on... ๐Ÿงต Image
2/ We've had an ongoing debate on how much (or little) #saturated fat consumption is responsible for high #LDL #cholesterol levels we typically see for #LMHRs.

Whereas I (we) believe #LEM to have greater relevance overall.

Which led to the experiment๐Ÿ‘‡
3/ Could @DrNadolsky emulate the #LMHR phenotype while *not* being fat adapted? (or at least, to get his #LDL #cholesterol that high?)

He consumed two sticks of butter a day to test this! ๐Ÿงˆ๐Ÿงˆ

Yes, the experiment went more toward my prediction, so alas, I won't be flying there.
Read 7 tweets
Jun 18
1/ It begins...

Naturally, the #LEM would be a bit suggestive of this outcome where a diet is mid to moderately higher carb for this context.

Low TG typical of metabolic health.
Lower turnover of VLDL-TG = lower total cholesterol, lower LDL cholesterol, and lower HDL...
2/ If replacing M/PUFA with SFA but keeping all else equal (including -- importantly -- carbs) for this exact context, this might have a marginal impact on TC/LDL/HDL. But would it command a higher magnitude of increase? I'd be doubtful...

However, if replacing carbs with fat...
3/ ... Thus going lower carb, we get closer to the model around LEM and its explanation regarding TC/LDL-C/HDL-C changes toward the outcome magnitude of the LMHR phenotype.

Hence the value of looking to RER for this experiment to confirm/disconfirm fat-adaptation.
Read 4 tweets
Jun 15
1/5 This is BIG & I've really been looking forward to it. @DrNadolsky will be looking to see if he can reach a #LMHR phenotype while not being low carb or keto (or at a minimum, increase LDL-C to 200)

In short, can high consumption of saturated fat w/o being fat-adapted = #LMHR?
2/5 There's a bit of back-and-forth that originated this experiment which you can read about here ๐Ÿ‘‡

And yes, this could literally result in my flying to him to confirm results directly with advanced bloodwork & RER (Respiratory Exchange Ratio)

3/5 But more importantly, this gets to a very common assumption regarding #LMHRs -- that their phenotype can be mostly explained by higher consumption of saturated fat.
Read 5 tweets
Jun 13
๐Ÿ“ฃ๐Ÿ“ฃ๐Ÿ“ฃBig #diabetes #bundle drop for @ownyourlabs

๐ŸทIntroductory Sale for 5% until June 20th!

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OwnYourLabs.com/diabetes
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After much research, we decided on 4 variations of the bundle (see below)...
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Read 5 tweets
Jun 7
1/ New video by @NutritionMadeS3 which I'd like to retweet for added discussion.

There's a layperson-friendly section in it that does a great job of illustrating the existing expectation of:

(1) LDL/ApoB Exposure Size
X
(2) Time
=
Rate of Plaque Development
2/ Using "mg-years" (much like "pack years" with cigs), one can quickly figure out what state of cumulative exposure they'd be at.

Gil's graph in video was similar to the one I tweeted on last week ๐Ÿ‘‡

And indeed, this is the convention of exposure x time
3/ To be sure, I'd echo @NutritionMadeS3's qualifier in the video that this is expected at a population level. So the exceptions don't prove the rule (in either direction).

Hence the enormous importance of studying those with extremely high LDL/ApoB at a population level...
Read 8 tweets

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