Discover and read the best of Twitter Threads about #cholesterol

Most recents (9)

Wow - low #LDL is a pretty significant risk factor for death
- non-statin users here, no confounding
- and deaths within 3 years removed from analysis too!… #LDLBS #Cholesterol
396,951 people here, all ages, very fair sample, no statins involved to muddy the waters - mmnnn... @JeffryGerberMD @DrHorwitz @ProfTimNoakes @bokkiedog
Read 3 tweets
In five days we begin filming #TheCCDoc -- a documentary on #Lipids, #HeartDisease, and the phenomenon of higher #LDL #Cholesterol observed in many following the #keto/#lchf lifestyle.

This will either be a single feature length documentary (90-120m) or a series of topic episodes (40-55m each)

I'll be interviewing experts across the opinion spectrum. Pro lipid hypothesis, moderate, skeptic, liberal on statins vs conservative, etc.

We'll explore:
1. History of cholesterol discovery
2. The #LowCarb movement and high "diet induced" #LDL
3. The science and data of risk: intervention, genetic, and observational
4. The two Triads, atherogenic dyslipidemia and ⬆️LDL+⬆️HDL+⬇️Triglycerides

Read 9 tweets
1/ I think this would be a great time to discuss my process, particularly in connecting with people who feel very strongly that I’m wrong.

Why give anyone time or attention that has disparaged me or people I care about in the course of making their arguments?
2/ A cynical reading of this would be that I’m trying to bolster a reputation of being evenhanded while secretly being completely attached to my viewpoint all along.

A generous one would be that I’m truly seeking the challenge my hypotheses and finding the best people to do it.
3/ The irony is that I believe — if I’m being a good scientist — I don’t know how much the first is true vs the second.

But I do know this...

... It’s very hard to defend a hypothesis that is flawed if you find the very best people to shoot it down.
Read 15 tweets
1. I've been studying @DaveKeto's videos. I've concluded that LDL #Cholesterol is very much like DOGs. Dogs are 'lousy' and should be lowered at all costs.

Let's say you have open wounds. Dogs will likely lick your cut, introduce infection, and cause mortality.
@DaveKeto 2. Let's say, too, you're allergic to dogs. Higher levels of dogs will aggravate your condition resulting in a decline in quality of life. Plus, if you have open wounds, dog dander is no bueno. Dogs have been known to follow you into the bathroom. Unheigenic to say the least.
@DaveKeto Dogs are scary. A marauding band of dogs can give you such a fright, that you just keel over and die of a heart attack. Very much like high LDL Cholesterol.
Read 11 tweets
🚨 Watch out, time for another #cholesterol #tweetorial! 🚨This time we’re going to take a look at the very fundamental nature of cholesterol molecule. It has biochemical properties that make it 1) essential to life but 2) problematic in excess. So let’s get to it! (1/33)
First, as everyone can read in wikipedia or a high-school level biology book, cholesterol is used to make many things. It’s a good building block for certain hormones, cell membranes and bile acids. But why? (2/33)
The reason is this sturdy multi-ring structure that has many “corners” for attaching stuff. Depending on specific needs, different types of molecular side chains can be attached to this basic frame (3/33)
Read 33 tweets
#Tweetorial time! 🚨 Looks like there’s another misconception about #cholesterol and #atherosclerosis making rounds again. This one has to do with the process of #LDL particles entering the arterial wall. So gather round friends and let me science the s*it out of this 🤓 (1/24)
For background, here’s a widely cited series of figures by Nakashima et al. (2007). They performed autopsies on 38 people aged 7-49, who died of non-#cardiovascular causes (2/24)
Nakashima et al. looked for atherosclerotic lesions at different stages, according to a previously published morphological classification scheme. They found them, took slices, stained them to find #lipids and #macrophages and organized them nicely (3/24)
Read 25 tweets
🚨 Thread time! 🚨 Fascinating research *letter* (lol, contains more data than many "regular" papers combined!) published in @nature. Looks at the molecular mechanism of how #LDL #cholesterol particles get into arterial walls and cause #atherosclerosis |…
The authors build upon previous knowledge that a particular scavenger receptor (SR-B1) has a key role. As the name implies, scavenger receptors pick up all sorts of stuff from their surroundings (2/14).
First, a transgenic mouse is made that has SR-B1 knocked out *specifically* from endothelial cells. This was done in combination with different athero-prone- and control mice and the data consistently shows that if there's no SR-B1, there's much less atherosclerosis (3/14)
Read 14 tweets
@my_helix @uk_biobank @my_helix took a look at 1,317 @uk_biobank phenotypes w/ 50,000 exomes released last week. Going beyond #GWAS, used gene-based collapsing analysis. Thanks @bmneale Pheasant pipeline for clean phenotypes, @hailgenetics for the tooling.
@my_helix @uk_biobank @bmneale @hailgenetics Found some stuff that we expected, #LDLR for #cholesterol, #MC1R for red hair; but counts too small for other known conditions like HBOC/#BRCA2 @ATorkmani @RobertCGreen @atulbutte @gabecasis
@my_helix @uk_biobank @bmneale @hailgenetics @atorkmani @RobertCGreen @atulbutte @gabecasis Some interesting findings: #GP1BB associated with mean platelet volume. #GP1BB variants have been implicated in bleeding and platelet disorders.
Read 8 tweets
Considering #statin in 35-y-o man worried about extensive family history of MI+stroke: 2 parents, 3 of 4 sibs.

#Cholesterol 5.8 mM, 224 mg/dl. Subtypes typical for such a total.
Non-smoker. Otherwise average.

[Live-quiz from #orbita-HQ for #cardioTwitter fellows & the curious]
Question C2.

First vote was for diet first, and quite right too! That is the guideline, and we must obey.

Natural, organic, eco-friendly and therefore best.

What effect size is a reasonable expectation, for patient and Dr, for the reduction of total cholesterol by diet?
Question C3.

(currently 0.8 mmol/L in the lead for Question C2)
There are several ways to choose a value. Which did you use?
Read 47 tweets

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