New preprint looking at 32,536 ppl giving birth in Melbourne 🇦🇺of whom 17,356 received a #CovidVaccine in #pregnancy
👉🏻 Congenital abnormalities, preterm birth and stillbirth all significantly *lower* in the vaccinated group.
medrxiv.org/content/10.110…
👉🏻 Congenital abnormalities, preterm birth and stillbirth all significantly *lower* in the vaccinated group.
medrxiv.org/content/10.110…
🤓 Section
Though this is in line with what we expect, I was surprised to see such clear results in a single study - albeit a big one. Is there a bias here?
In this cohort the vaccinated are generally healthier and wealthier, but the authors adjust for this. 2/
Though this is in line with what we expect, I was surprised to see such clear results in a single study - albeit a big one. Is there a bias here?
In this cohort the vaccinated are generally healthier and wealthier, but the authors adjust for this. 2/
They also restrict the sample to ppl for whom weeks 20-43 following LMP fall entirely within the study period, to avoid fixed cohort bias. 3/
They do a subgroup analysis showing that *even if you catch COVID*, being vaccinated ⬇️ preterm birth, though numbers too low to adjust for covariates in this subgroup). 4
My one beef is that they do a sensitivity analysis on congenital abnormalities in only those vaccinated <20 weeks. I believe <12 weeks would have been more appropriate here since this is the critical period for development. 5/
But overall, I think this is a really carefully done study, which should give us confidence in these results, even though at first glance I thought they were too good to be true! 6/6
PS! With thanks to @John_P_Topham who brought this one to my attention!
PPS! Have just found the author of this study here on Twitter. Nice study @LisaHui4!
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