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Clarissa E. Jordan, MD Profile picture
@pathcejmd
Jul 13, 2022 • 11 tweets • 4 min read • Read on X
If you follow me, you know I love tweeting about #HemePath and lately #AML subtypes🩸

So far, I’ve covered the subtypes of AML with recurrent genetic abnormalities (per WHO 2016) - see below if you’re interested! ⬇️

Looking forward to more HemePath #tweetorials in the future! Image
AML with mutated NPM1
AML with t(8;21)(q22;q22.1) RUNX1::RUNX1T1
AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFB-MYH11
APL with PML::RARA
AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A
AML with t(6;9)(p23;q34.1);DEK-NUP214
AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1
AML with biallelic mutations of CEBPA
Cases also archived on my website 🗂

✨ Always learning — welcome any feedback! And looking forward to more #HemePath soon! ✨

P.S. - if you liked this series, please consider voting for me & other lab professionals in this year’s #ASCP40UnderForty

ascp.org/content/get-in…

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More from @pathcejmd

Clarissa E. Jordan, MD Profile picture
Mar 2, 2022
🩸#HemePath AML subtype #PathTweetorial 🧵

Which cytogenetic/molecular finding is most consistent with this morphology? (Poll⬇️)

#PathTwitter #MolecularPath #MedEd @MayoClinicPath
(P.S. Always learning - I welcome any feedback!) ImageImage
Which cytogenetic/molecular finding is most consistent with this morphology? AML with…
Answer: ✨inversion of chromosome 16 is associated with acute myeloid leukemia with abnormal eosinophils✨

These abnormal eosinophils have mixed eosinophilic and basophilic granules Image
Read 11 tweets
Clarissa E. Jordan, MD Profile picture
Jan 15, 2022
Hey #path2path #PathMatch22 applicants! Thinking about your rank list and wondering what📍Rochester, Minnesota is like?

In a word, beautiful 😍

A 🧵 for those who won’t get a chance to visit us this #virtual interview season! @MayoClinicPath @MayoClinic
Just to get it out of the way…

YES, it gets cold here 🥶❄️ Yes, it snows 🌨

But as someone who grew up in the desert ➡️ and then lived in TX 🤠 ➡️ if I can handle it, you definitely can too! (Just need to get yourself some good gear🧥🥾 - I’ve got suggestions!)
If you don’t want to go outside in the winter, Mayo Clinic & Rochester have tunnels & sky bridges connecting the med center w downtown, including from the parking ramps to the hospital 🏥
But personally, I’m excited for outdoor activities like snowshoeing & cross-country skiing!
Read 11 tweets
Clarissa E. Jordan, MD Profile picture
Sep 28, 2021
Catching up on 🧬 “Understanding #NGS and Interpreting Reports for Oncologic Pathology” with Dr. @sabahkadri and Dr. Cecilia Yeung at #CAP21 @AMPath 👩🏻‍💻

Super useful talk with excellent case studies! Here are just a few takeaways 🧵⬇️ #MolecularPath_CEJ #Informatics_CEJ
🤔 Considerations in developing an NGS assay

📌 @Pathologists has NGS assay development tools regarding test design, validation, quality, and bioinformatics: cap.org/member-resourc…
📌 How much do you want to know? ➡️ what test is needed? (WGS vs WES vs targeted sequencing)

1/
🧬 NGS in a nutshell with Dr. Yeung

1️⃣ Library preparation (hybrid capture vs amplicon-based)

2️⃣ Sequence the fragments of DNA (cyclic reversible termination vs detection of chemical byproducts ⚡️ as single nucleotide is added)

2/
Read 15 tweets
Clarissa E. Jordan, MD Profile picture
Sep 28, 2021
🧬#MolecularPath “Selecting the Right Tool for the Job: Practical Considerations for the Application of Molecular Diagnostics Methods in SurgPath” with @LJTafeMD and Dr. Larissa Furtado

A few takeaways (just scratching the surface of this excellent talk!) ⬇️🧵#MolecularPath_CEJ Image
First up: Pre-analytical Considerations

Purposes of molecular oncology testing:

🔵 Diagnosis
🔵 Therapy response/management
🔵 Monitoring

1/
Considerations for molecular oncology testing:

🔵 Availability of specimens
🔵 Testing options: targets 🎯, analytical sensitivity, TAT ⏱, cost
🔵 Clinical scenario
🔵 NCCN guidelines

2/
Read 18 tweets

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