BREAKING🔔 The 13th preprint from G2P-Japan🇯🇵 is out @biorxivpreprint. #Omicron BA.2.75 (aka #Centaurus) seems to be more contagious than BA.5 and more pathogenic than the original BA.2. Please RT. 1/7
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
BA.2.75, emerged in India🇮🇳, is classified as VOC-LUM (variant of concern linage under monitoring) by WHO on July 7. Here we elucidated the effective reproduction number, sensitivity to antiviral immunity & drugs and intrinsic pathogenicity of BA.2.75. 2/7
who.int/activities/tra…
who.int/activities/tra…
Both BA.2.75 and BA.5 are descendants of BA.2. However, BA.2.75 is phylogenetically different from BA.5, the currently predominant BA.2 descendant. BA.2.75 spike bears nine substitutions, but only one substitution (R493Q) is shared with BA.5 spike. 3/7 
First, our mathematical/statistical analysis revealed that the effective reproduction number ("Re" in the figure) of BA.2.75 is greater than that of BA.5, suggesting that BA.2.75 is more contagious than BA.5. 4/7
While the sensitivity of BA.2.75 to vaccine- & BA.1/2 breakthrough infection-induced immunity was comparable to that of BA.2, the BA.5-induced immunity (*in hamsters) was ineffective against BA.2.75. Three clinically-available antiviral drugs were effective against BA.2.75. 5/7
Using clinical isolates of BA.2, BA.2.75, BA.2 & Delta and a hamster model, we demonstrated that the intrinsic pathogenicity of BA.2.75 is comparable to that of BA.5 but is greater than that of the original BA.2. 6/7
▶️ Our multiscale investigations suggest that BA.2.75 acquired virological properties independently of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5. 7/7
• • •
Missing some Tweet in this thread? You can try to
force a refresh
