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Aug 11 • 6 tweets • 2 min read
This one in generally healthy Finnish women suggests that the menopause-induced hormonal shift results in a proatherogenic metabolomic fingerprint, and that hormone therapy can partially modify this by influencing LDL, HDL, and glycine metabolism. Image
- The authors identified 64 of the 180 observed metabolites as ‘menopause responsive’, that is, the variance in oestrogen and FSH directly explained 2–11% of these metabolites’ variances.
- The concentrations of apolipoprotein B, very-low density lipoprotein, triglycerides, LDL-c and HDL-c, shifted towards a pro-atherogenic profile.
- The levels of the ketone bodies 3-hydroxybutyrate and acetoacetate also declined.
- Menopausal hormone therapy was associated with an improved lipid and lipoprotein metabolome compared with untreated women.
Menopause modulates the circulating metabolome: evidence from a prospective cohort study (open access)

doi.org/10.1093/eurjpc…

#MetabolicSyndrome #Cholesterol #Triglycerides #women #hormones

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More from @nick_krontiris

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Aug 14
This systematic review and meta-analysis finds that both unilateral and bilateral resistance training may improve athletic performance, but the former may be superior on improving unilateral jumping performance and the latter bilateral strength performance.
- Both unilateral and bilateral resistance training were found to improve athletic performance, with no differences in performance measures.
- Subgroup analysis showed that unilateral resistance training can improve unilateral jumping performance with a large effect, but probably provides no benefit on improving unilateral strength performance in comparison to bilateral exercises.
Read 6 tweets
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Aug 14
This systematic review and meta-analysis suggests that high HbA1c variability in individuals with type 2 diabetes may lead to micro- and macro-vascular complications and related death.
- Individuals with type 2 diabetes among the highest quantile HbA1c of all 3 variability metrics had increased risks of all-cause mortality, cardiovascular events, progression to CKD, amputation, and peripheral neuropathy.
- Those among the highest quantile of at least one HbA1c variability metric hadh increased risks of kidney failure, progression to albuminuria, diabetic foot ulcer, and retinopathy.
Read 4 tweets
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Aug 14
In this one, even though 6 months CrossFit training (2×60 min/week) did not improve measures of well-being in inactive adults with predominantly sitting or standing occupations, it resulted in improved mobility and strength.
- The study recruited individuals with a predominantly standing or sitting occupation that did less than two muscle and/or mobility enhancing training sessions per week prior study participation.
- After 6 months significant effects were found for mobility and strength, but not for measures of well-being.
Read 6 tweets
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Aug 13
This study tried to investigate how self-identified dietary lapses, which are defined broadly as eating that is inconsistent with one or more dietary goals, affect reported dietary intake among individuals undergoing a lifestyle modification intervention. ImageImage
- When controlling for their usual intake, participants consumed more calories and added sugar on days on which they reported dietary lapses.
In comparison to prescribed calorie goals (1200–1800 kcals/day based on starting weight), participants consumed an unadjusted average of 253.85 calories above their prescribed goal on lapse days...
Read 6 tweets
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Aug 13
This one found a high adipose tissue insulin resistance in normotensive individuals at baseline, as assessed by adipo-IR, to be associated (although weakly) with new-onset hypertension. Image
- In this study, the authors investigated the association between three insulin resistance indices (adipo-IR, HOMA-IR, and the Matsuda index) and hypertension in older Japanese individuals.
- In the cross-sectional analysis, all of these insulin resistance indices were statistically significantly associated with blood pressure levels.
Read 10 tweets
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Aug 13
This one suggests that aerobic physical activity durations of 3 hours/week and resistance training exercise ~1–2 times/week may substantively reduce the risk of all-cause mortality, with their combination confering additional mortality risk reduction beyond cardio alone. ImageImage
- Higher aerobic PA duration was found to be robustly associated with lower mortality risk and was optimised at ~3 hours/week, largely independent of age and sex. ImageImage
Across all models, an inverse association of aerobic PA with mortality risk with doses as short as ~1 hour/week were found, with results suggesting little additional mortality risk reduction beyond 3 hours/week.
Read 14 tweets

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