Thread by @nick_krontiris

This Mendelian randomization study finds that a higher childhood body size has a direct effect on lower vitamin D levels in early life, while in midlife, childhood body size impacts adult obesity indirectly to result in lower vitamin D levels.

- Evidence of an effect for higher adult body size on lower 25OHD levels measured in adulthood was found in the multivariable model accounting for the childhood body size score.

This suggests that childhood body size has an indirect influence of 25OHD levels in adulthood, likely due to its persistent effect throughout the lifecourse.

- These findings suggest that increased adiposity exerts a strong effect on lower vitamin D levels during both childhood and adulthood.

Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study (open access)

doi.org/10.7554/eLife.…

#MetabolicSyndrome #Obesity #VitaminD