This one found a high adipose tissue insulin resistance in normotensive individuals at baseline, as assessed by adipo-IR, to be associated (although weakly) with new-onset hypertension. 
- In this study, the authors investigated the association between three insulin resistance indices (adipo-IR, HOMA-IR, and the Matsuda index) and hypertension in older Japanese individuals.
- In the cross-sectional analysis, all of these insulin resistance indices were statistically significantly associated with blood pressure levels.
"This suggests that insulin resistance plays a significant role in BP control regardless of the tissue in which it occurs."
- In the cohort analysis, a high adipo-IR in normotensive individuals at baseline was significantly associated with new-onset hypertension after mutlivariate adjustment.
- Conversely, the statistical significance of the association between a high HOMA-IR or low Matsuda index and incident hypertension was lost after adjusting for baseline BP levels.
To make things more interesting, the combination of high adipo-IR with high HOMA-IR or low Matsuda index had no higher odds of hypertension than high adipo-IR alone.
"These results suggest that insulin resistance is associated with BP control regardless of the tissue in which it occurs; however, the risk of hypertension is determined by insulin resistance in adipose tissue rather than in liver or muscle tissue...
"...Insulin resistance in different tissues can have different pathophysiological effects."
Adipose tissue insulin resistance predicts the incidence of hypertension: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases
doi.org/10.1038/s41440…
#MetabolicSyndrome #InsulinResistance #Hypertension #BloodPressure
doi.org/10.1038/s41440…
#MetabolicSyndrome #InsulinResistance #Hypertension #BloodPressure
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