This one found a high adipose tissue insulin resistance in normotensive individuals at baseline, as assessed by adipo-IR, to be associated (although weakly) with new-onset hypertension.
- In this study, the authors investigated the association between three insulin resistance indices (adipo-IR, HOMA-IR, and the Matsuda index) and hypertension in older Japanese individuals.
- In the cross-sectional analysis, all of these insulin resistance indices were statistically significantly associated with blood pressure levels.
"This suggests that insulin resistance plays a significant role in BP control regardless of the tissue in which it occurs."
- In the cohort analysis, a high adipo-IR in normotensive individuals at baseline was significantly associated with new-onset hypertension after mutlivariate adjustment.
- Conversely, the statistical significance of the association between a high HOMA-IR or low Matsuda index and incident hypertension was lost after adjusting for baseline BP levels.
To make things more interesting, the combination of high adipo-IR with high HOMA-IR or low Matsuda index had no higher odds of hypertension than high adipo-IR alone.
"These results suggest that insulin resistance is associated with BP control regardless of the tissue in which it occurs; however, the risk of hypertension is determined by insulin resistance in adipose tissue rather than in liver or muscle tissue...
"...Insulin resistance in different tissues can have different pathophysiological effects."
Adipose tissue insulin resistance predicts the incidence of hypertension: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases

doi.org/10.1038/s41440…

#MetabolicSyndrome #InsulinResistance #Hypertension #BloodPressure

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Aug 14
This systematic review and meta-analysis finds that both unilateral and bilateral resistance training may improve athletic performance, but the former may be superior on improving unilateral jumping performance and the latter bilateral strength performance.
- Both unilateral and bilateral resistance training were found to improve athletic performance, with no differences in performance measures.
- Subgroup analysis showed that unilateral resistance training can improve unilateral jumping performance with a large effect, but probably provides no benefit on improving unilateral strength performance in comparison to bilateral exercises.
Read 6 tweets
Aug 14
This systematic review and meta-analysis suggests that high HbA1c variability in individuals with type 2 diabetes may lead to micro- and macro-vascular complications and related death.
- Individuals with type 2 diabetes among the highest quantile HbA1c of all 3 variability metrics had increased risks of all-cause mortality, cardiovascular events, progression to CKD, amputation, and peripheral neuropathy.
- Those among the highest quantile of at least one HbA1c variability metric hadh increased risks of kidney failure, progression to albuminuria, diabetic foot ulcer, and retinopathy.
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Aug 14
In this one, even though 6 months CrossFit training (2×60 min/week) did not improve measures of well-being in inactive adults with predominantly sitting or standing occupations, it resulted in improved mobility and strength.
- The study recruited individuals with a predominantly standing or sitting occupation that did less than two muscle and/or mobility enhancing training sessions per week prior study participation.
- After 6 months significant effects were found for mobility and strength, but not for measures of well-being.
Read 6 tweets
Aug 13
This study tried to investigate how self-identified dietary lapses, which are defined broadly as eating that is inconsistent with one or more dietary goals, affect reported dietary intake among individuals undergoing a lifestyle modification intervention.
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In comparison to prescribed calorie goals (1200–1800 kcals/day based on starting weight), participants consumed an unadjusted average of 253.85 calories above their prescribed goal on lapse days...
Read 6 tweets
Aug 13
This one suggests that aerobic physical activity durations of 3 hours/week and resistance training exercise ~1–2 times/week may substantively reduce the risk of all-cause mortality, with their combination confering additional mortality risk reduction beyond cardio alone.
- Higher aerobic PA duration was found to be robustly associated with lower mortality risk and was optimised at ~3 hours/week, largely independent of age and sex.
Across all models, an inverse association of aerobic PA with mortality risk with doses as short as ~1 hour/week were found, with results suggesting little additional mortality risk reduction beyond 3 hours/week.
Read 14 tweets
Aug 13
This one found that brain activity and related brain structures differ between triathletes and people who do not exercise regularly, suggesting that exercise might not only improve the ability of self-regulation of physical activity but also self-regulation of brain activity.
- Triathletes showed a superior ability of self-regulating their own brain activity during neurofeedback training, especially over a longer period of time.
This improved neurofeedback performance in triathletes appeared to be related to larger gray and white matter volumes of the insula and inferior frontal gyrus.
Read 4 tweets

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