Yes, this exactly what many policy makers mean and meant with "Living with Covid". Actually, it's much worse. These are just some neurological problems. We knew covid led to severe cardiovascular, cardiopulmonary, multi-systemic, immune-related etc. sequelae already in 2020
We knew about #LongCovid in 2020. Publications already existed about the dramatic sequelae of SARS before 2020. We knew we were facing a SARS-like disease as soon as information about the Wuhan outbreak emerged

crisis24.garda.com/alerts/2019/12…
We knew we were facing a potential pandemic driven by a virus similar to the deadly SARS CoV on 24 January 2020 maximum. This is when the first China's data were published in the top scientific journal @TheLancet e.g.

thelancet.com/journals/lance…
The WHO openly recognized #LongCovid in August 2020. We knew by September of the same year the damages inflicted by Covid were multi-systemic, affected children too, were not rare, had a severe cardiovascular potential, and led to immense costs e.g.

wellcomeopenresearch.org/articles/5-224
We knew SARS-CoV-2 was airborne before many authorities openly talked about it. Airborne prevention isn't being implemented if not in "selected" settings like for the elite
We knew already in late 2021 Omicron could go beyond our immune defense e.g.

sciencedaily.com/releases/2021/…
We knew other viruses had the potential to cause sequelae and/or prolonged disease like with ME, post-polio syndrome, the sequelae of influenza #longflu and pneumonia, post-Ebola syndrome and the sequelae of SARS, among others, just to name a few
Despite this knowledge, a relentless policy of letting a SARS virus rip through the population has been pushed by many governments, especially with omicron. The real dangers and mode of transmission of SARS-CoV-2 haven't been fully, openly discussed with people in many cases
The population through which SARS-CoV-2 was let to rip includes children, very senior people, people with dementia, people living in care homes, people in hospitals etc., who couldn't conset to this in any way, or protect themselves. Those with #LongCovid were left with no care
I appreciate Dr Topol's effort to communicate the dangers of #LongCovid and specifically of neurological impairment from the study shared above. This is important as many verified Twitter accounts just, often, only deny/minimize the terrible burden of LC
But I also want to add that policy makers know or must know of the long term effects of SARS-CoV-2 infection. They most likely know in 2020 too. Certainly, the burden and pathophysiology of #LongCovid has become more clear with time.
We're still letting SARS-CoV-2 rip
So yeah, neurological and multi-system disease is exactly what our policy makers and the uber-elite mean by Living With Covid. Maybe not for themselves, but for us outside their ranks and their affiliates for sure
I don't want to Live With Covid. But I am forced to do so, so as the uber wealthy can become richer, and policy makers won't have the inconvenience of planning for a true exit strategy from the pandemic they have driven to this stage.
I don't have the "tools".

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More from @elisaperego78

Aug 20
This is an interesting study, evaluating reduced blood supply to the heart because of endothelial damage to the vascular system
In line with clinical signs and symptoms reported by those with #LongCovid since the early pandemic

H/t @loscharlos

jacc.org/doi/full/10.10…
Symptoms associated to this cardiovascular issue include chest pain, dyspnea, especially on exertion, when there is an increased demand to the heart
We have know since the early pandemic covid is hard on the endothelium. Prolonged endothelial dysfunction is attested in #LongCovid
New endothelial injury or a decline in already suboptimal endothelial function due to Covid are flagged as potentially critical problems. Severe cardiac events, including death, are a possible effect of poor vascular/endothelial activity around the heart #LongCovid
Read 14 tweets
Aug 19
Jools Oliver, wife of British star chef Jamie Oliver, has suffered from #LongCovid for two years, with medical professionals apparently unable to help
dailymail.co.uk/news/article-1…
The usual disclaimer: #LongCovid isn't as mysterious as the article makes it look like! There are thousands of publications on Long Covid and associated complications, like pulmonary embolism and diabetes. And a huge, enormous number on acute covid and other post-viral diseases
H/t @SGriffin_Lab for sharing!
Read 4 tweets
Aug 19
On a positive side, High Jump Olympic champion G. Tamberi came back, after a complex covid recovery, to win the gold at the European Championships tonight. Interestingly, I've found this interview, where Tamberi speaks openly about #LongCovid risk

🧵

corrieredellosport.it/news/altri-spo…
Tamberi had a mild covid case in 2021. He came back strong with excellent performances, but tested positive again in July 2022 after the World Championships. This time, he suffered from more prolonged symptoms like extreme fatigue, headache and pain, after a week of fever
In the interview above, from a few days ago, interestingly, Tamberi mentions directly #LongCovid: "many are speaking about it". He expressed concern about his participation at today's European Championships, and confirmed to have discussed his symptoms with his physiotherapist
Read 6 tweets
Aug 6
"The last mystery of Covid"
Italy's official cases are dropping but the daily death toll has increased on average.
Strange. Really. Italy isn't testing, enough, indoor mask mandates were dropped, and mortality is a lag indicator

Mild and Mysterious™️ 🎆

repubblica.it/cronaca/2022/0…
1022 people have died officially from covid in the last week. Excess mortality is almost 6%
Experts, however, are perplexed. They attribute mortality to poor treatment and the heatwave
I can't exclude these are contributing factors. But we are on an unleashed BA.5 wave
Increased mortality and hospitalization are the results of letting SARS-CoV-2 spread with no mitigation, and a relatively limited access to a second booster, within the rise of a variant with troubling features, like the ability to go beyond prior immunity to an extent
Read 4 tweets
Aug 5
SARS-CoV-2 and cancer | pre-print

"..numerous cancer-related genes [were] up-regulated in SARS-CoV-2 infected patients, particularly those genes participating in the cell cycle regulation or engaged in cellular senescence processes"

#LongCovid
researchsquare.com/article/rs-189…
"Conclusion: Our findings suggest that SARS-CoV-2 can be considered a potential risk factor for increasing the probability of developing cancer"

@longcoviditalia
In this context [= previous studies suggesting a link] our analysis revealed that the up-regulated genes in COVID-19 is similar to cancer processes at least in three different categories including: cell cycle regulation, viral carcinogenesis, and cellular senescence."
Read 12 tweets
Aug 5
This study has multiple major flaws. It doesn't actually document #LongCovid but identify individuals who matched a fictitious clinical case definition invented by the authors. We have to stop working on bizzare symptom-based studies to accelerate with pathophysiology and trials
Some flaws of the study. First, it's a symptom-based questioner, based on a reduced, rather random list of symptoms, which the authors apparently selected themselves. It doesn't capture the complexity of #LongCovid as a disease entity, with a wide palette of biomarkers and signs
The exclusion criteria may have also prevented many to partecipate, including the most severe or from marginalised communities= "severe mental illness, short life expectancy (<5 years), insufficient knowledge of Dutch language, and not being able to visit a general practitioner"
Read 9 tweets

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