The big impact of a disease in little kids. Characteristics & Outcomes of Multisystem Inflammatory Syndrome in the #PedsICU. Great work @kindly_kel @picudoc13 @DrKenRemy1 @RBC_PICU @MKleinBiostats @JanineZeeCheng @ColinRogerson5 @AlexRotta @caseymccluskey journals.lww.com/pccmjournal/Fu…
#MIS_C is a clinical syndrome of systemic inflammation that occurs 4–6 weeks after exposure to #SARSCoV2 affecting the heart, lungs, kidneys, brain, skin, and GI system. Review by @MontyMazer @yoncabulutmd @nina_brodsky @drsturge @RBC_PICU @DrKenRemy1 journals.lww.com/pccmjournal/pa…
In this paper, we used the @vps_llc to track trends in #MIS_C in 115 #pedsICU’s since the beginning of the pandemic, and compared outcomes over time (and by strain). Of the 145,580 children admitted to the PICU, 1,338 children (0.9%) were admitted with #MISC.
In this cohort, the disease burden for #MIS_C was high with an overall median hospital LOS of 6.6 days (IQR 4.7-9.3) and a median #pedsICU LOS of 2.7 days (IQR 1.6-4.7). Overall 15.2% of children with #MISC were intubated & mechanically ventilated. There were 11 hospital deaths.
There was a significant decrease in hospital & #PedsICU LOS and frequency of intubation in children with #MISC between Quarter 3 and 4 of 2020. Driving factors for this decrease may have been due to improvement in therapeutic interventions, increased recognition, or viral strain.
Given the timing of the spread of the different viral strains, an improved understanding of MIS-C is a more likely explanation for improved outcomes. The predominant viral strain of #SARSCoV2 changed in Q1 of 2021, after the observed improvement in outcomes.
From May 2020 to early 2021, there was a rapid growth in understanding of #MIS_C and dissemination of knowledge. @Twitter helped! (as @AnnaZanin_MD @Nopanaden @MiguelrrMD @LaCampo4 @rolandoug @mevillar @sgdambrauskas @sapnaKmd have already shown!) #pedsICU journals.lww.com/pccmjournal/Fu…
Please see the link below for a copy of the full paper. And thanks to @PedCritCareMed for publishing this! And to my co-authors @kindly_kel @picudoc13 @DrKenRemy1 @RBC_PICU @MKleinBiostats @JanineZeeCheng @ColinRogerson5 @AlexRotta @caseymccluskey #pedsICU journals.lww.com/pccmjournal/Fu…
This marks the FIFTH (!) paper from the PEACE group. Involvement in with this group has been one of the great professional experiences of my career. I’m continually amazed at everyone's collaborative spirit, insightfulness and productivity. Excited to see what the future holds!

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Chris Carroll MD

Chris Carroll MD Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @ChrisCarrollMD

Jun 22, 2021
Lately, I’ve been reflecting a lot of how much racism has affected our understanding of the pathophysiology of asthma in children. And how the pandemic has exposed just how wrong so many of the underlying assumptions were. A thread 🧵 1/11
Some background. Asthma is the most common chronic disease in children, affecting 1 in 7 children at some point during childhood. Each year approximately 10,000 children/year are admitted to a #PedsICU with severe asthma. 2/11
Severe asthma exacerbations disproportionately affect BIPOC children, with higher rates of hospitalization, ICU admission and intubation. 3/11
Read 11 tweets
Oct 21, 2020
Last live lectures of #CHEST2020 about to start! Excited for the Airways Controversy Lecture with @virenkaul @Chaeface @DavidBowton and David Bell.
@Chaeface: Starting it off with DL vs VL with @DavidBowton! #CHEST2020
@DavidBowton: I think it is a false argument. Should be using both of these depending on the circumstance. #CHEST2020
Read 17 tweets
Oct 21, 2020
@iamyourgasman: Immunotherapy for #COVID19. #CHEST2020
@iamyourgasman: We already knew that steroids might be helpful in ARDS. #CHEST2020
@iamyourgasman: RECOVERY Trial was set up within days in the UK. And has resulted in several trials. #CHEST2020
Read 9 tweets
Oct 21, 2020
@RanaAwdish: Restoration of Identity Post-COVID #CHEST2020
@RanaAwdish: I invite you to step out of our "CHEST" identity and step into the quieter parts of your identity. Loss of any one of these makes you less human. #CHEST2020
@RanaAwdish: Identity is a relational act. Embracing our intersectional identities will benefit our patients. #CHEST2020
Read 8 tweets
Oct 21, 2020
If you're missing this great lecture on "After COVID: Complications of a New Infection and its Aftermath" by @WesElyMD @RanaAwdish @hopealuko and Brenda Pun, make sure you catch the video! #CHEST2020
@RanaAwdish: There was much fear early in the pandemic. Fear of using PPE, wanting the patient to be comforted and having only medications to comfort them. But this may have been harmful. #COVID19
@hopealuko: #COVID19 symptoms can linger for some patients. #CHEST2020
Read 8 tweets
Oct 21, 2020
Coming up at 8:45am CT! The Roger Bone Honor Lecture: "To SIRS with Love" by Dr. Manny Rivers (yes, THAT Dr. Rivers). #CHEST2020
Starting now! @sqsimp talking about Roger C. Bone and introducing Dr. Rivers. #CHEST2020
@sqsimp: "Dr. Rivers introduction of time-based care and goal-based care has saved countless lives in sepsis" #CHEST2020
Read 12 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(