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Aug 29 • 5 tweets • 3 min read
If you are #pregnant in the UK, the NHS strongly recommend that you get the #CovidVaccine if you are not yet protected.

The advice has not changed!

nhs.uk/conditions/cor…
There seems to be some confusion because the full approval documents for the Pfizer vaccine - published a few weeks ago - note that Pfizer did not themselves do any studies of the vaccine in pregnancy.

Here's the relevant document... 2/

gov.uk/government/pub…
But this document describes only the data that Pfizer submitted to the MHRA, not the independently generated data we have from universities and government bodies, which track vaccine safety in more than 315,000 pregnant people and find no problem. 3/

drive.google.com/file/d/1_wHIYX… Image
In fact, vaccination in pregnancy seems to *reduce* the rate of stillbirth (almost certainly by preventing COVID infection and disease, which can cause stillbirth). 4/

nature.com/articles/s4146…
This is the data which the @NHSuk - and @RCObsGyn and @MidwivesRCM - have used to make their strong recommendation that people who are pregnant get vaccinated, if they have not done so already. 5/5

rcog.org.uk/guidance/coron…

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More from @VikiLovesFACS

Viki Male Profile picture
Aug 30
If you are #pregnant in the UK, the @NHSuk strongly recommends that you get the #CovidVaccine if you are not already protected.

The advice has not changed!

So why are some people saying that it has? 🤔

🧵...

nhs.uk/conditions/cor…
In December 2020, Pfizer submitted data on its vaccine to the MHRA for temporary approval, which was granted. The documents on this are in the public domain... 2/

gov.uk/government/pub…
Periodically, Pfizer sends the MHRA some more data. On 16 August, they sent some additional data on boosting with different brands of vaccine. The documents were updated accordingly. 3/

gov.uk/government/pub… Image
Read 9 tweets
Viki Male Profile picture
Aug 18
85,162 ppl giving birth in 🇨🇦May - Dec ‘21, of whom 43,099 had a #CovidVaccine during #pregnancy.

👉🏻 No increased risk of stillbirth, preterm birth or being born smaller than expected following vaccination.

1/
bmj.com/content/bmj/37…
In fact, the authors found a slight reduction in the risk of stillbirth and very preterm birth among those vaccinated. Although they controlled for known confounders, they didn’t feel confident that this wasn’t due to residual confounding. 2/
However, it is in line with the findings from other large studies which show a reduced risk of stillbirth following vaccination… 3/

nature.com/articles/s4146…
Read 4 tweets
Viki Male Profile picture
Aug 18
For those interested in the miscarriage rate among those who became pregnant during the trial of the Pfizer #CovidVaccine….

👉🏻 Vaccine group 7%

👉🏻 Control group 15%

👉🏻 These rates are not significantly different from each other, or from normal

1/
fda.gov/media/152256/d…
These data were published about a year ago, but ppl are talking about it today because Naomi Wolf has looked at the FOI data and claims she has found a miscarriage rate of 44%. Unclear how she has done this but seems to be a combination of… 2/
👉🏻 Accidentally counting everything twice (oops)

👉🏻 Counting some ppl who didn’t have miscarriages (eg. males)

👉🏻 Counting miscarriages among the control group (ie. ppl who did not get vaccinated). 3/3
Read 4 tweets
Viki Male Profile picture
Jul 7
New preprint looking at 32,536 ppl giving birth in Melbourne 🇦🇺of whom 17,356 received a #CovidVaccine in #pregnancy

👉🏻 Congenital abnormalities, preterm birth and stillbirth all significantly *lower* in the vaccinated group.

medrxiv.org/content/10.110…
🤓 Section

Though this is in line with what we expect, I was surprised to see such clear results in a single study - albeit a big one. Is there a bias here?

In this cohort the vaccinated are generally healthier and wealthier, but the authors adjust for this. 2/
They also restrict the sample to ppl for whom weeks 20-43 following LMP fall entirely within the study period, to avoid fixed cohort bias. 3/
Read 8 tweets
Viki Male Profile picture
Jun 27
@beverleyturner Morning Bev! We've discussed before how female fertility measures were including in the clinical trials. You can find a summary of the outcomes to November 2020 here... 1/

nature.com/articles/s4157…
@beverleyturner And updates on pregnancy outcomes in the Pfizer and AZ trial participants, to August 2021, here... 2/

fda.gov/media/152256/d…

thelancet.com/journals/lance…
@beverleyturner And of course we now also have very extensive data on female fertility following COVID-19 vaccination from the general rollout, with no sign of any harm to fertility in either IVF patients or those trying to conceive through intercourse. 3/
Read 10 tweets
Viki Male Profile picture
Jun 16
@SwaledaleMutton @AGreenroyd1958 @Amber84280581 @NathanaelYoung @somethingsummit @DavidTYork Hi Andrew! I can see why that would worry you, but some key context is missing. These weren’t people who became pregnant accidentally during the trials (though we do have that data too) but rather reports during the general rollout, up to the end of Feb 2021…
@SwaledaleMutton @AGreenroyd1958 @Amber84280581 @NathanaelYoung @somethingsummit @DavidTYork … At that point, around 48,000 people had been vaccinated in pregnancy. Most didn’t make any report because nothing worth reporting happened. You are looking only at the people who *did* make a report, who are naturally enriched for those who experienced a bad outcome…
@SwaledaleMutton @AGreenroyd1958 @Amber84280581 @NathanaelYoung @somethingsummit @DavidTYork (Sources for those numbers…)
Read 6 tweets

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