In December 2020, Pfizer submitted data on its vaccine to the MHRA for temporary approval, which was granted. The documents on this are in the public domain... 2/
Periodically, Pfizer sends the MHRA some more data. On 16 August, they sent some additional data on boosting with different brands of vaccine. The documents were updated accordingly. 3/
The data on pregnancy has not been updated since Dec 2020. This is because Pfizer has not sent additional data on this topic to the MHRA. However, independently-done studies on more than 135,000 ppl vaccinated in pregnancy show vaccination is safe... 4/
Because the August update of the Public Assessment Report still contains the December 2020 information - that Pfizer have not submitted pregnancy data to the MHRA - some ppl have interpreted this as being new information that supercedes the NHS advice - but it isn't! 5/
The @NHSuk advice - as well as advice from @RCObsGyn and @MidwivesRCM - strongly recommending #CovidVaccination in #pregnancy is based on the independently-generated data showing that vaccination is safe and effective in pregnancy. 6/
(This thread adds more information to one I tapped out super quickly last night, and in which there was an error - which I corrected in the thread. If you are sharing a thread on this, please consider sharing this one!) 8/8
First, let’s note that we do have some data on pregnancy from the COVID vaccine trials. Participants were asked not to become pregnant, but some did by accident. The outcomes for these pregnancies were monitored as part of the trials, with no concerns emerging. 2/
There seems to be some confusion because the full approval documents for the Pfizer vaccine - published a few weeks ago - note that Pfizer did not themselves do any studies of the vaccine in pregnancy.
But this document describes only the data that Pfizer submitted to the MHRA, not the independently generated data we have from universities and government bodies, which track vaccine safety in more than 315,000 pregnant people and find no problem. 3/
In fact, the authors found a slight reduction in the risk of stillbirth and very preterm birth among those vaccinated. Although they controlled for known confounders, they didn’t feel confident that this wasn’t due to residual confounding. 2/
However, it is in line with the findings from other large studies which show a reduced risk of stillbirth following vaccination… 3/
These data were published about a year ago, but ppl are talking about it today because Naomi Wolf has looked at the FOI data and claims she has found a miscarriage rate of 44%. Unclear how she has done this but seems to be a combination of… 2/
👉🏻 Accidentally counting everything twice (oops)
👉🏻 Counting some ppl who didn’t have miscarriages (eg. males)
👉🏻 Counting miscarriages among the control group (ie. ppl who did not get vaccinated). 3/3