Thread by @JohnEbbenMDPhD

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD 2/ #TumorBoardTuesday
Thurs Case🎀

Take🏠messages :
PIK3CA mutations in ER+ #mBC
✅PIK3CA mut are common- 20-30% of all #BreastCancer & 40%+ of ER+ #mBC
✅PIK3CAm are present in founder clones!

📚We captured as much of the discussion as we could:
Pt 1 twitter.com/i/events/15719…

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD 3/5 #TumorBoardTuesday
Thursday Case🎀

Take🏠messages (Part 2):
✅Alpelisib is a PIK3CA inhib= 5.3 mo ⬆️in PFS
✅Side effect mgmt is key- esp. 💩diarrhea,
🍦hyperglycemia
✅Personalized medicine needs personalized side effect mgmt

Part 2 of our convo twitter.com/i/events/15729…

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD 4/5 #TumorBoardTuesday
📷 TBT in an image: Take a look at how PIK3CA inhibitors can be clinically deployed, key side effects to watch out for, and the data that supports their use.

👀Look for more developments in this space and even more, highly specific inhibitors to come.

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD @esinghimd @EricaMarieRomn1 @ca_pik3 @RenoHemonc @OncBrothers @marina_sharifi 5/5 #TumorBoardTuesday
Thursday Case🎀

Thank you to @maryamlustberg & @JasmineSukumar for an excellent #TBT- PIK3CA= new 2L option, but with side effects that need proactive mgmt!

➡️Join us on 𝗠𝗢𝗡𝗗𝗔𝗬 10/03/22 at 8PM ET: @n8pennell discusses Dato-DXd #NSCLC 3L 🫁

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD @esinghimd @EricaMarieRomn1 @ca_pik3 @RenoHemonc @OncBrothers @marina_sharifi @maryamlustberg @n8pennell Remember #TumorBoardTuesday continues to offer AMA & now MOC credit for FREE! Don’t forget to answer the polls👇🏽
Then click this link to quickly request your credit!
CME eval🔗: integrityce.com/tbteval
ALL CME 🔗: integrityce.com/tbt

https://twitter.com/jasminesukumar/status/1572391112643604484?s=46&t=uKlu4ujdrDpvsxSsqGpB2Q

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD @esinghimd @EricaMarieRomn1 @ca_pik3 @RenoHemonc @OncBrothers @marina_sharifi @maryamlustberg @n8pennell @RenoHemonc @YLeyfman @Liz_ORiordan @PTarantinoMD @NicoleKuderer @hoperugo @OncBrothers @benjiwal @JaniceTNBCmets @StoverLab @GoPI3Ks @Neil_Iyenger @Dr_RShatsky @crisonco @CarmenCalfa @drteplinsky @ChrisJ_Shepherd @ParamMD

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD @esinghimd @EricaMarieRomn1 @ca_pik3 @RenoHemonc @OncBrothers @marina_sharifi @maryamlustberg @n8pennell @YLeyfman @Liz_ORiordan @PTarantinoMD @NicoleKuderer @hoperugo @benjiwal @StoverLab @GoPI3Ks @Dr_RShatsky @crisonco @CarmenCalfa @ChrisJ_Shepherd @jennifermarksmd @quirogad @Robertalom3 @DraAnaCasas @KinhHoangMD @KariWisinski_MD @HannahAlison20 @CeeCeepants @HillStirSci @BianchiniGP @EricaMarieRomn1 @TimothyJBrownMD @aachmielewski @JineshGheeya @nursekristinrn @LaceyJudith @Sorena997 @bermandr2
@Neil_Iyengar

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@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD @esinghimd @EricaMarieRomn1 @ca_pik3 @RenoHemonc @OncBrothers @marina_sharifi @maryamlustberg @n8pennell @YLeyfman @Liz_ORiordan @PTarantinoMD @NicoleKuderer @hoperugo @benjiwal @StoverLab @GoPI3Ks @Dr_RShatsky @crisonco @CarmenCalfa @ChrisJ_Shepherd @jennifermarksmd @KellyMezaMD @anu_iris @ShrutiPatelMD @s_santiesteban @Adrianvlee @NeilVasan @DrJNaidoo @DrRBarroso @EthanSokol @UmutDisel @ValsamoA @jberchuck @ValerieTeng @MamMa_mimumemo @mabelonc @FernandoOnco @oncologician @ravi0273 @antoniomarraMD @EduDFonseca22 @DrJen15 @florencecoussy1

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD @esinghimd @EricaMarieRomn1 @ca_pik3 @RenoHemonc @OncBrothers @marina_sharifi @maryamlustberg @n8pennell @YLeyfman @Liz_ORiordan @PTarantinoMD @NicoleKuderer @hoperugo @benjiwal @StoverLab @GoPI3Ks @Dr_RShatsky @crisonco @CarmenCalfa @ChrisJ_Shepherd @jennifermarksmd @KellyMezaMD @YAbdouMD @ErikaHamilton9 @FilipaLynce @dradityabardia @DrSGraff @SusanGKomen @HeekeMd @DrHBurstein @tmprowell @antonyruggeri @sardesai_sagar @OncoAlert @realdrgabriel

@barrosolab @drenriquegrande @DrTashaG @RICKLIN4TH @ProfWishart @ProfAMThompson @oncoplastics @LuengoGil

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD @esinghimd @EricaMarieRomn1 @ca_pik3 @RenoHemonc @OncBrothers @marina_sharifi @maryamlustberg @n8pennell @YLeyfman @Liz_ORiordan @PTarantinoMD @NicoleKuderer @hoperugo @benjiwal @StoverLab @GoPI3Ks @Dr_RShatsky @crisonco @CarmenCalfa @ChrisJ_Shepherd @jennifermarksmd @KellyMezaMD @YAbdouMD @ErikaHamilton9 @FilipaLynce @dradityabardia @DrSGraff @SusanGKomen @HeekeMd @DrHBurstein @tmprowell @antonyruggeri @BreastDocUK @LiangRhea @Lucarecco @aftimosp @matteolambe @manjuggm @KoheiShitara @itsnot_pink @Al3ssandroRusso @JavierCortesMD
@PTarantinoMD

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD @esinghimd @EricaMarieRomn1 @ca_pik3 @RenoHemonc @OncBrothers @marina_sharifi @maryamlustberg @n8pennell @YLeyfman @Liz_ORiordan @PTarantinoMD @NicoleKuderer @hoperugo @benjiwal @StoverLab @GoPI3Ks @Dr_RShatsky @crisonco @CarmenCalfa @ChrisJ_Shepherd @jennifermarksmd @KellyMezaMD @YAbdouMD @ErikaHamilton9 @SorenBentzen @Carmela_surgery @abhenilmittal @seiichi_mori @Prof_M_Ristow @Gobnait @jansen_marnix @MeriemMakhlou11 @ImaiMitsuho @rafa_p10 @TBlackburn25 @DrLauraEsserman @nancyjmac1 @dra_izabela @nwabudike_sm @Nat71553043 @AChargy @MridulaGeorgeMD @Rick_Villalobos

@TumorBoardTues @maryam_lustberg @JasmineSukumar @MPishvaian @JaniceTNBCmets @drteplinsky @ParamMD @esinghimd @EricaMarieRomn1 @ca_pik3 @RenoHemonc @OncBrothers @marina_sharifi @maryamlustberg @n8pennell @YLeyfman @Liz_ORiordan @PTarantinoMD @NicoleKuderer @hoperugo @benjiwal @StoverLab @GoPI3Ks @Dr_RShatsky @crisonco @CarmenCalfa @ChrisJ_Shepherd @jennifermarksmd @KellyMezaMD @YAbdouMD @ErikaHamilton9 @SorenBentzen @Carmela_surgery @abhenilmittal @seiichi_mori @Prof_M_Ristow @Gobnait @jansen_marnix @OlgaMartnezSez1 @BarbaraPistill2 @NagiSaghir @Myshastry @geneman20042000 @drsarahsam @DFCI_BreastOnc @nlinmd @elmayermd @kazuki_nozawa @SherryShenMD @MCristofanill