Eric Topol Profile picture
Sep 23 7 tweets 4 min read
New US #SARSCoV2 genomic surveillance data
The proportion of BA.5 cases is declining, as new variants are out-competing, some of which have already been shown to have more immune escape such as BA.2.75.2 and BQ.1.1
covid.cdc.gov/covid-data-tra… Image
Here @SolidEvidence has mapped out their evolutionary path with a convergence of several mutations Image
And @EllingUlrich has an insightful thread about both the convergent and non-convergent mutations for the new variants
ImageImage
For opera, "It ain't over till the fat lady sings"
For the pandemic, It ain't over (contained, under control, ahead of it) till we get better vaccines that block infections and spread (e.g. nasal) and are variant-proof, pan-sarbecovirus
New info on the major variants on the radar screen, by @yunlong_cao
And my prior post on 2 with immunoprofiling (BA.2.75.2 and BQ.1.1)
Pandemic virus sequencing has provided the notable edge of seeing variants before they go exponential, characterizing them, determining in advance whether and which treatments (mAbs), vaccines will be effective
More here: devex.com/news/sponsored… by @PhilFebboMD_CMO

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More from @EricTopol

Sep 21
There are too many new #SARSCoV2 variants on the radar screen that show growth advantage vs BA.5, and 2 with extreme immune evasiveness to date. One is a BA.5 descendant, BQ.1.1; the other is derived from BA.2, BA.2.75.2. They share a RBD mutation, R346T
(Maps from @PeacockFlu)
Here's the full, frequently updated list cov-spectrum.org/collections/24 @GenSpectrum
Thanks to so many keeping a close eye on these, including @siamosolocani @CorneliusRoemer @PeacockFlu @SolidEvidence @LongDesertTrain @richardneher and others 🙏
Correction, thanks @siamosolocani
There are 2 receptor binding domain mutations shared by these variants
Read 4 tweets
Sep 20
Why the pandemic isn't over yet and how we can get there faster
latimes.com/opinion/story/…
my @latimes oped Image
A bit of contrast in views
washingtonpost.com/opinions/2022/… Image
Read 4 tweets
Sep 19
Wish this was true. What's over is @POTUS's and our government's will to get ahead of it, with magical thinking on the new bivalent boosters. Ignores #LongCovid, inevitability of new variants, and our current incapability for blocking infections and transmission
And what about the 400-500 Americans dying each day since April
Or that only 1 of 3 Americans have had any booster shot. A proclamation "it's over" is not going to help that
erictopol.substack.com/p/to-boost-or-…
Read 4 tweets
Sep 18
Lifting the booster fog
The evidence supporting boosters is incontrovertible. Summary of data for 4th vs 3rd shots for survival benefit, age 50+
The unequivocal benefit is for enhanced protection vs severe Covid Image
2. The most recent @CDCgov data, compared with unvaccinated, age 50+
4 shots: 94% reduction of death
3 shots: 83.5% reduction of death Image
3. The magnitude of benefit has been consistent over time, for different Omicron subvariants. Here in May, across all ages, H/T @redouad, 96% reduction of death for 4 shots vs unvaccinated Image
Read 13 tweets
Sep 8
Excellent, succinct review of myalgic encephalomyelitis (ME/CFS) and its overlapping features with #LongCovid
@ScienceMagazine
science.org/doi/10.1126/sc… Image
Full text here ImageImage
The comprehensive list of validated treatments for ME/CFS and #LongCovid.
This has to change. Image
Read 4 tweets
Sep 6
The @BharatBiotech nasal vaccine got EUA regulatory approval in India today following its ~4,000 participant randomized trial timesofindia.indiatimes.com/india/bharat-b…
Efficacy data not yet presented
This follows yesterday's first inhaled vaccine approval, in China, representing a 2nd major step in the quest for achieving mucosal immunity vs Covid
Nasal and oral vaccines are our best shot to block infections, transmission, achieve containment of the virus, reduce the toll of sickness, & help prevent #LongCovid. They are not getting adequate priority in the US science.org/doi/10.1126/sc… w/ @VirusesImmunity @SciImmunology
Read 4 tweets

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