Viki Male Profile picture
Sep 27 11 tweets 4 min read
This study looked at #breastmilk after #CovidVaccination in 11 people.

👉🏻 mRNA detectable in whole milk of 3 of them

👉🏻 Maximum concentration 0.1 parts per billion

👉🏻 This is roughly equivalent to a single tear in an Olympic pool

1/

jamanetwork.com/journals/jamap…
The findings are roughly in line with two previous studies which concentrated breast milk in order to detect very low quantities of vaccine mRNA (in fact, this one finds a little less). Low et al... 2/

The authors conclude that the very low levels found suggest that mRNA COVID vaccination is safe during breastfeeding, and this is in line with the findings of other safety in breastfeeding studies, which you can find here, under q11... 4/

docs.google.com/document/d/1_w…
I wouldn't be worried by this myself, but the authors note that anyone who is might prefer to be "cautious" (I guess pump and dump?) for 48h after vaccination.

They also say we should consider the needs of those who are breastfeeding more in medical research - and I agree! 5/5
PS! Some additional points that have come up in the comments. Assuming this mRNA was active vaccine, how much milk would we need to make a dose? 6/
For a 100 mg dose of Moderna, about 50 bathtubs. For a 30 mg dose of Pfizer, only 15. Or for a pediatric dose (10mg), only 5 bathtubs.

You can pump that, right? 7/

But vaccines are not just mRNA - the lipids and PEG are also important components without which they won't work. So is there any evidence that these components get into breast milk? 8/

Thanks for reminding me of this study of 50 people, which asked exactly that question and was unable to detect PEG in breast milk. 9/

This is actually what the authors of this recent paper suggest - that it's vaccine mRNA being produced in the breast and recruited into extracellular vesicles (EVs) rather than vaccine itself. 10/10
PS. As a couple of people have pointed out, I have said “mg” when I meant to say “ug”. That’s a typo rather than a factor of 1000 error, but thanks all for being so vigilant!

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More from @VikiLovesFACS

Sep 28
19,622 ppl tracking #periods, of whom 14,936 receive #CovidVaccine

👉🏻 Dose 1 associated with a 0.7d delay to the next period

👉🏻 Dose 2: 0.6d delay

👉🏻 2x doses in one cycle: 3.91d delay

👉🏻 Back to normal next cycle

👉🏻No change to period length

🧵…

bmjmedicine.bmj.com/content/1/1/e0…
We see these effects with all types of COVID vaccine (mRNA, adenovirus, inactivated virus), suggesting this is likely to be a result of the innate immune response – akin to side effects such as sore arm and fatigue – rather than an effect of any particular vaccine component. 2/
This is in line with previous reports on COVID vaccines, as well as some old reports from other types of vaccine. 3/

theguardian.com/commentisfree/…
Read 10 tweets
Sep 26
@NoMaloneZone @qandamazon I’ve read it so you don’t have to! (Though read it. It’s short, at least.)

We begin by noting that vaccines save lives – true. We go on to discuss the author going on breakfast television – also true (I understand) but not normally the stuff of the scientific literature. 1/
@NoMaloneZone @qandamazon The author then talks about the death of his 73-year-old father from coronary artery disease. I’m sorry for his loss. 2/
@NoMaloneZone @qandamazon The author then speculates that his father’s CAD might have been caused by receiving an mRNA COVID vaccine six months earlier. He notes that in the trials there was no evidence of increased CAD in the vaccine group (true). 3/
Read 31 tweets
Sep 1
Most of the very extensive data showing that #CovidVaccines are safe and effective in #pregnancy was collected in the general rollout.

Is this okay? Shouldn’t we have trial data?

Let’s talk about the ethics of vaccine trials in pregnancy! 🧵…

drive.google.com/file/d/1_wHIYX…
First, let’s note that we do have some data on pregnancy from the COVID vaccine trials. Participants were asked not to become pregnant, but some did by accident. The outcomes for these pregnancies were monitored as part of the trials, with no concerns emerging. 2/
Because…

1. What little data we had was reassuring

2. What we know of 💉 biology suggested there would not be any problems in 🤰🏻

3. COVID 🦠 *does* cause problems in pregnancy

… some countries 🇺🇸 🇮🇱 opted to offer the 💉 and let 🤰🏻 decide

3/
Read 14 tweets
Aug 31
If you are #pregnant, the #CovidVaccine is strongly recommended and you will soon be offered a booster. #BoostTheBump

The recommendation is made on the basis of extensive data that the vaccine is safe and effective, by the following bodies… 1/

drive.google.com/file/d/1_wHIYX…
The UK government… 2/

gov.uk/government/pub…
Read 8 tweets
Aug 30
If you are #pregnant in the UK, the @NHSuk strongly recommends that you get the #CovidVaccine if you are not already protected.

The advice has not changed!

So why are some people saying that it has? 🤔

🧵...

nhs.uk/conditions/cor…
In December 2020, Pfizer submitted data on its vaccine to the MHRA for temporary approval, which was granted. The documents on this are in the public domain... 2/

gov.uk/government/pub…
Periodically, Pfizer sends the MHRA some more data. On 16 August, they sent some additional data on boosting with different brands of vaccine. The documents were updated accordingly. 3/

gov.uk/government/pub…
Read 9 tweets
Aug 29
If you are #pregnant in the UK, the NHS strongly recommend that you get the #CovidVaccine if you are not yet protected.

The advice has not changed!

nhs.uk/conditions/cor…
There seems to be some confusion because the full approval documents for the Pfizer vaccine - published a few weeks ago - note that Pfizer did not themselves do any studies of the vaccine in pregnancy.

Here's the relevant document... 2/

gov.uk/government/pub…
But this document describes only the data that Pfizer submitted to the MHRA, not the independently generated data we have from universities and government bodies, which track vaccine safety in more than 315,000 pregnant people and find no problem. 3/

drive.google.com/file/d/1_wHIYX… Image
Read 5 tweets

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