Landmark trial thread🧵

This series of tweets will be about key trials studying SGLT-2 inhibitors in heart failure. While initially studied for DM, these meds were shown to improve CV outcomes in CHF patients, regardless of DM status.

#MedEd #EBM #CardioTwitter #clinicaltrials Image
1) DAPA-HF trial:
Among patients with a reduced EF, the risk of worsening heart failure or death from CV causes was lower among those who received dapagliflozin vs placebo.

Link: nejm.org/doi/full/10.10… ImageImage
2) DELIVER trial:
Dapagliflozin reduced the combined risk of worsening heart failure or CV death in patients with heart failure and a mildly reduced or preserved EF.

Link:
nejm.org/doi/10.1056/NE… ImageImage
3) EMPEROR-Reduced trial👑

Among patients with heart failure and LVEF < 40%, those in the empagliflozin group had a lower risk of CV death or hospitalization for HF than those in the placebo group, regardless of diabetes status.

Link: nejm.org/doi/full/10.10… ImageImage
4) EMPEROR-Preserved trial👑

Empagliflozin reduced the combined risk of CV death or hospitalization for heart failure in patients with heart failure and a preserved EF, regardless of the presence or absence of diabetes

Link: nejm.org/doi/full/10.10… ImageImage
5) SOLOIST-WHF trial:

In patients with DM and worsening HF, sotagliflozin therapy resulted in significantly fewer deaths from CV causes and hospitalizations and urgent visits for heart failure than placebo.

Link:
nejm.org/doi/full/10.10… ImageImage
These trials opened up an important avenue of management for heart failure. If you know of other RCTs for SGLT-2 inhibitors in heart failure patients then please share!

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Landmark Trials

Landmark Trials Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(