Discover and read the best of Twitter Threads about #clinicaltrials

Most recents (24)

NCI Pooled analysis (N=6.9K) of antiPD1/PDL1:
👉0.6% incidence CPI-related major cardiac AEs, 77% grade 3+
👉Almost half were myocarditis
👉 Twice as common w/ combos vs monotherapy & w/ CPI + targeted agent vs CPI + antiCTLA4…
👉Major cardiac AEs were mostly early events (1-2 months) occurring after median of 2 doses of CPI
👉1/4 of cases of myocarditis were fatal, all preceded by myositis 👀
👉Diverse clinical presentations so have high index of suspicion to diagnose & intervene early…
My commentary: It’s also concerning (& not surprising given what we know about pro-inflammatory metabolic syndrome as a cardiac risk fx) that markedly ⬆️ risk of MI has been reported in pts with multi-yr use of CPIs. I predict this follows a course much like HIV…
Read 6 tweets
So Dr. Mattias Desmet would wholeheartedly agree that despite refusing his own vaccine, #RobertMalone suffers from #MassFormationPsychosis.

Should we be surprised then that no one is willing to defend against this accusation but rather in psychotic fashion simply deny it.
You cannot say you have or are recovering from psychosis when the number one symptom is denial and Robert as well as hundreds of doctors from the #AcademicProfessionalClass continue to deny that THEY suffer a #SustainedPsychoticEpisode.

All the while accusing everyone else.
This includes @P_McCulloughMD @PierreKory @BretWeinstein @richardursomd @DrJBhattacharya @jordanbpeterson and so many others who continue their #ConditionedResponse to the pandemic to effectively #GriftForDollars while DENYING they are the very people Mattias is referring to.
Read 6 tweets
A positive step at #WHA75 today! Cochrane is pleased to see that @WHO Member States passed the resolution on strengthening #clinicaltrials and improving research quality & coordination. ➡️… 1/5 Image
This @WHO resolution that was passed at #HA75 calls on Member States to:
⬆️increase #clinicaltrial capacity globally
🌟 prioritise well-designed trials
🤝 better coordinate trial efforts
🔎affirms the importance of clinical trial transparency
Many of the #clinicaltrials issues highlighted in today's passed #WHA75 resolution were recommendations in the Cochrane Convenes report. 📜
#ConvenesReport @CConvenes 3/5 Image
Read 5 tweets

May 8th = World Ovarian Cancer Day 2022 #WOCD2022

A thread 🧵 on some points I wish to relay as a Medical Oncologist with subspecialty in GYN oncology and based in fair Ireland 🇮🇪

The most common symptoms of ovarian cancer are the #BEAT symptoms - always get checked out by your GP if you have these or other symptoms that are not resolving


There is no reliable #screening test for ovarian cancer

❌ Pap smears do not diagnose ovarian cancer
❌ Ca125 is not a reliable test
❌ Pelvic/vaginal USS may miss a diagnosis or overdiagnose a normal cyst

Until we have better screening, symptoms are all we have #BEAT
Read 8 tweets
EMA Press Briefing on COVID-19 related activities, 5 May 2022…
#COVID19 infections are still in the millions worldwide. This pandemic is far from over. COVID-19 will continue to impact our lives. #EMAPresser #pandemic
Vaccines are a central pillar of the response to the #pandemic. Nearly half a million lives among people 60 years of age and older have been saved in Europe thanks to #vaccination. #COVID19 #EMAPresser
Read 12 tweets
Yesterday at #TargetedChat we talked about a challenging case of a young individual with recurrent UNRESECTABLE colon cancer after adjuvant.

Here’s a 🧵 on the questions/answers. No one right away. What would you do differently?👇🏾Read/reply along #ColorectalCancerAwarenessMonth Image
It was interesting to see the distribution on the chemo backbone options.

👇🏾With the doublets and triplets discussion, a little bit of art 🖼 to the science 🧪

Have to see and individualize in each patient which tools 🛠 from the toolbox 🧰.

#TargetedChat #CRCSM #ColorectalCancer #ColorectalCancerAwarenessMonth Image
Read 9 tweets
They simply don't care anymore and have no reason to do so.

They're just trying to inject as many people as possible at this point.

#KillAtWill #NoHoldsBarred #InjectOnSight #CastrateTortureMaim it is all fair game.

Where's a #GoodDoctor when you need one?

Are these the faces of doctors attempting to stop #MedicalGenocide?

For decades they provided #SilentObedience to the #MedicalIndustrialComplex run by their Master, #TonyFauci.

And today they are nothing more than #FauciDogs providing a #ConditionedResponse just like chronic
sufferers of a #SustainedPsychoticBreakFromReality they so readily like to label the rest of us as being.

When in reality it is they who suffer more than anyone.

Just ask #RobertMalone as he continues to get people #AllButteredUp, saying Covid vaccines are here to stay!
Read 11 tweets
Preguntas y respuestas con #InmunoUnicornio 🦄💫

Pregunta: ¿Nos podrías explicar que está pasando con la #vacuna para menores de 5 años? ¿Qué ue diferencia tiene un niño 4 años 11 meses y uno de 5 años que no acaban por sacar la vacuna?

Respuesta 🧵👇🏼


Lo que sucede es lo siguiente:

En los #EnsayosClínicos 📑 (y en #ciencia en general) se deben controlar las condiciones de la intervención lo más posible para asegurar que los resultados observados 👁 sean atribuibles a dicha intervención y no a factores externos

En este caso, la intervención es la aplicación de la #vacuna 💉

Y dos de las condiciones principales a controlar son la dosis del antígeno (la molécula contra la cual se van a formar los #anticuerpos) y la edad de las personas que participan en el estudio


Read 13 tweets
Today we're thrilled to announce results of our PREVENT-19 Phase 3 pediatric expansion to adolescents (ages 12 through 17). Let's talk about the data and what they mean. Thread:
Today's results build on findings from the adult main study, investigating the safety & efficacy of NVX-CoV2373 in the United States and Mexico amidst an evolving #COVID19 pandemic:… #clinicaltrials
The pediatric expansion randomized adolescents age 12 through 17, in the U.S., in a 2:1 ratio to receive 2x 5μg doses of NVX-CoV2373, our investigational #vaccine candidate, or placebo, 21 days apart. Protocol:…
Read 22 tweets
While it wasn't the same as being in person, the 2022 @SU2Cscience Scientific Summit Community Gathering was inspiring as always. Excellent talk from @NCIDirector on strides being made, and work yet to be done. A few key points that resonated. 🧵 1/7 Image
Cancer mortality is down. Oncology leads the way in biomedical research that translates to tangible results for patients, with a striking number of new FDA approvals annually. One of the drivers of this success is our growing understanding of cancer biology through basic science Image
A great example of this is the #kidneycancer drug belzutifan. Building upon the @NobelPrize winning research from @kaelin_lab researchers at @UTSWNews developed this drug, it was further tested and re-formulated by a small biotech (Peleton therapeutics) then bought by @Merck Image
Read 7 tweets
Shout out to participants in #clinicaltrials. I’m enrolled in an NIH RADx-supported trial that requires me to do #COVID19 rapid tests & PCR every other day within a time window, & then drive a pkg to a FedEx every other day by 3p. This is the 4th study I’ve joined in my life…
The studies I’ve been in have ranged from pregnancy outcomes yrs ago to #COVID19 diagnostics. I keep joining them because I believe #ScienceWillWin, but also because it’s important to be reminded what a genuine hassle it is to be in a study. /2
In the very best of circumstances, it’s an inconvenience. It ALWAYS costs participants something, whether it’s missed work, lost wages, childcare, gas for a 🚗, discomfort, or more. And it’s always one more thing in a day that may already have way too many things already (🙋🏻‍♀️). /3
Read 6 tweets

#Pat is just chompin' at the bit to expose #TheOther, the #AntiVaxxers, #TheUnvaccinated, who he believes are sadistic for having no empathy for #TheVaccinated who have wished us dead for two years now.

Let's honor his request and agree to a #PublicDebate!
Maybe @Trevornoah @TheDailyShow could Host the debate for your team.

Trevor what say you?

It's been 2 years that we have offered an #OpenInvitation to ANYONE willing to have a #PublicDebate OR...

Expose themselves as #ComplicitCowards unwilling to defend their lies!

@billmaher @StephenAtHome @chrislhayes @maddow @KeithOlbermann @HowardStern @robreiner @Lawrence

If you refuse to have the courage to debate publicly in a free society, then you are cowards who destroyed our country and deserve being vaccinated with an #ExperimentalVaccine.
Read 20 tweets
Well, I got 2 messages before 9am from friends telling me they have #COVID19 in their households. And in the 12 mins since, I’ve just heard about 4 more. So Merry Exponential Growth #Omicron #Christmas. 🌲 😫

A quick 🧵 on what to do if that’s you since I’m typing it anyway.
1/ The first thing to say is that if someone has #COVID19 symptoms (#Omicron most common: nasal congestion/runny nose, scratchy sore throat, fever, & aches), you have to assume they have it. You may not have a test (urgent cares are still open & do) or they may still be neg.
2/ You, as the person exposed to the one with symptoms, have to assume that you both do & don’t have #Omicron too. Wait, what? 🤔

I mean: assume you could infect others now & take care to avoid exposing them, BUT don’t assume it’s too late for you to avoid getting it.
Read 24 tweets
Scientific Basis for #Novavax #Covovax NVX-CoV2373 Superior Efficacy against broad range of Variants
Unlike the mRNA and adenovirus vaccines which only present a portion of the spike protein RBD (Receptor Binding Domain) to the immune system, Nuvaxovid presents the entire 1/9
“prefusion stabilized” Recombinant spike protein in a virus-like particle. The remainder of the spike protein apart from RBD’s in Nuvaxovid is also a site of neutralizing epitopes and that region is not heavily mutated in omicron.

NVAX (academic 2/9
collaborators actually) used a wild-type virus assay which means they used actual prototype and omicron viruses in the assays. They tested against the real deal. Moderna OTOH measured neutralization in a more common pseudo-virus assay – a non-coronavirus engineered to have 3/9
Read 11 tweets
1/14 🆕 🚨Accelerated article on #breastcancer just out in @nature! #bcsm

We asked:
1️⃣ What drives response to #chemotherapy in #breast #cancer
2️⃣ Can we use #machinelearning to predict response to chemotherapy❓


A 🧵👇👇👇 @OncoAlert
2/14 We are unable to #predict #response to treatment in clinic…

✅Good response ➡️treatment very effective ➡️better survival
❌Poorer response ➡️treatment less effective ➡️worse survival

Being able to forecast response would be a landmark advance!
3/14 We ran a study in women with #breastcancer @CUH_NHS+@CRUK_CI:
1️⃣who had a #cancer biopsy (which we analysed)
2️⃣received 18 weeks of chemo+/-targeted therapy
3️⃣had surgery (and we measured how much cancer remained)

We associated PRE-therapy profiles↔️POST-therapy response👇
Read 14 tweets
Volume 100 of @jstatsoft: Software for Bayesian Statistics

Guest editors: @micameletti & @precariobecario

20 contributions on a wide range of methods #rstats #python #bayesian #inla @mcmc_stan #nimble #brms #rjags

URL: Editorial for the special volume 100 in the Journal of Stati
Van Niekerk, Bakka, Rue, Schenk:

New Frontiers in Bayesian Modeling Using the INLA Package in R

#rstats #inla #bayesian…
Michaud, De Valpine, Turek, Paciorek, Nguyen:

Sequential Monte Carlo Methods in the nimble and nimbleSMC R Packages

#rstats #bayesian #nimble…
Read 21 tweets
The most meaningful comment from #NORDSummit for me was by @DrMichelleBIO on a panel on the impact of COVID on #raredisease research and drug development: "...the social compact around #clinicaltrials is broken." (🧵1/7)
"You know, it's hard to expect
people to leave their jobs, leave their children without childcare, come to clinical centers for numerous appointments on top of what's required for their illness to test a product that they might not have access to at the end of the day." (🧵2/7)
"We have depended on the overwhelming goodwill of patients to conduct trials up to now and I think it's time for us to reconsider the incentives because what's at stake is huge." (🧵3/7)
Read 7 tweets
Faire sa biblio dans #PubMed sans s'arracher les cheveux: un (long) thread

⚠️ Précaution d'emploi (1/2)

Les trucs et astuces qui suivent ne sont valables que pour une utilisation « au quotidien » de PubMed. N'utilisez pas les outils qui suivent pour réaliser une revue systématique ou une méta-analyse !!!!
⚠️ Précaution d'emploi (2/2)

Tout ceci est destiné à faire des recherches rapides, sans se prendre la tête et sans y passer des heures.

Ca ne remplace *évidemment pas* l'aide que peut vous apporter un(e) documentaliste en santé pour des recherches plus fines. 🤓
Read 102 tweets
We're thrilled to announce that PREVENT-19 (US/Mex Phase 3) results were submitted for publication. The manuscript is now available as a pre-print. Let's dive into what we found. Thread:…
PREVENT-19 builds on observations from other/ongoing #clinicaltrials, investigating the safety & efficacy of NVX-CoV2373 in the United States and Mexico amidst an evolving #COVID19 pandemic.…
The trial randomized adults age 18+ in a 2:1 ratio to receive 2x 5μg doses of NVX-CoV2373, our investigational #vaccine candidate, or placebo, 21 days apart.… Image
Read 16 tweets
Welcome back, George.

Now, about that "race-to-the-bottom" slashing of #data #protections...
...which, despite fine words about "maintaining high standards", is plainly the intent of @DCMS's proposed #DataProtection 'reforms':…

...which include the intent to (re)define "#ScientificResearch" 🤔🤔🤔
Of course, we understand #TIGRR's "enthusiasm for #digital", its eye on the value of "highly #profitable consumer data", and frustration with the pesky #protections and #safeguards of #UKGDPR...…
Read 6 tweets
Draadje over #ivermectin omdat ik hier toch heel wat over lees en hoor in de #tweedekamer. Ik zal hier delen wat ik weet met de bijbehorende onderbouwing. Dit draadje is geen pro/anti ivermectine discussie maar puur info delen om te helpen bij beeldvorming en discussievoering.
#ivermectine is tegen parasieten zoals darmlintwormen en wormen die leiden tot rivierblindheid. Het medicijn tast het zenuwstelsel en ingewanden van de parasiet zodat het sterft. Voorbeeld voor gebruik bij lintworminfectie via varkens:…
De Amerikaanse FDA heeft het middel toegestaan voor parasitaire infecties en niet voor covid-19. Maar #ivermectine wordt ook al een tijdje getest op virus remmende werking. In sommige studies wordt het omgekeerde beweerd wat incorrect is!…
Read 19 tweets
NEWS: Novavax Announces #COVID19 Vaccine Booster Data Demonstrating Four-Fold Increase in Neutralizing Antibody Levels Versus Peak Responses After Primary Vaccination…
Following the primary vaccination series (21 days apart), a single booster dose at 6 months of NVX-CoV2373 induced a robust increase in anti-Spike antibody levels - up ~4.6-fold vs the response seen after the primary series.
The increased antibody response was consistent for both younger and older adults.
Read 12 tweets
Getting❓about how #COVID #vaccines were tested & granted EUAs so quickly? I sure am, esp from folks "on the fence" or taking the "wait & see" approach.

👇Here's an infographic you can use to explain the #clinicaltrials process.

#epitwitter #MedTwitter #vaccinehesitancy Clinical trials process: pre-clinical research through Phase
2/Pre-clinical research:
Decades of groundwork prepared the scientific community for this moment:
🦠6 other human coronaviruses
💉mRNA & viral vector vaccine technologies
3/Clinical trials:
No #clinicaltrials phases were skipped. The scientific community was 'all hands on deck' w/many layers of red tape removed.

🐌In 'normal' times @NIH may require 1yr PLANNING grant b4 eligible to submit Phase 3 trial grant (>2yrs b4 full grant MIGHT get funded)
Read 9 tweets

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