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In 1954 [Yale J Biol Med], Bennett and Beeson reported “there is a lag period of about one hour between the time of the sudden influx of bacteria and onset of the rigor, and the blood is often sterile by the time fever begins.
In 1954 [Yale J Biol Med], Bennett and Beeson reported “there is a lag period of about one hour between the time of the sudden influx of bacteria and onset of the rigor, and the blood is often sterile by the time fever begins.
Among seven medical centers and 1,436 patients, Riedel et al [J Clin Microbiol. 2008; 46(4): 1381-5] reported “the likelihood of documenting bloodstream infections was not significantly enhanced…at the time patients experienced temperature spikes”
In a retrospective report to determine predictors of bacteremia, Taniguchi et al [Springerplus.2013; 2: 624] reported:
1. Among 18-79 yrs of age, shaking chills had aOR 2.22 (95% CI: 1.09-4.51)
2. Among 80+ yrs of age, shaking chills had aOR 3.06 (95% CI: 1.3-7.19)
1. Among 18-79 yrs of age, shaking chills had aOR 2.22 (95% CI: 1.09-4.51)
2. Among 80+ yrs of age, shaking chills had aOR 3.06 (95% CI: 1.3-7.19)
In a prospective observational study to determine lag time between shaking chills and positive blood cultures, Taniguchi et al [Int J Infect Dis. 2018; 76: 23-8] reported:
1. Within 2-hours, 53.6% (52/97)
2. After 2-hours, 37.6% (44/117)
1. Within 2-hours, 53.6% (52/97)
2. After 2-hours, 37.6% (44/117)
In a more recent prospective study by Holmqvist et al [Epidemiol Infect. 2020; 148: e86] reported 34% (11/32) with positive blood cultures had shaking chills compared to 14% (23/165) with negative blood cultures.
Therefore, obtaining blood cultures within 2-hours of shaking chills might be an optimal time to obtain blood cultures rather than with fevers or fever spikes.
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