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william wright Profile picture
william wright
@wfwrighID
ABIM Infectious Diseases, ABP Medical Microbiology (Yale), and MPH (Epidemiology). Posts not legal medical advice or affiliated endorsements.
Nov 30, 2022 • 6 tweets • 3 min read
#IDTwitter #SIDPharm #Microbiology

#AMRrounds called about this microbiology confirmed isolate and susceptibility results (AMR Step 1) associated with a clinically confirmed infection (Clinical ID Step 1) inquiring about AMR and treatment options. Image AMR Step 2: Understanding natural (intrinsic) mechanisms of resistance.

Outer membrane protein A of A baumannii (AbOmpA) attributed to intrinsic resistance through interaction of OmpA-like domain and efflux pump. DOI: 10.1093/jac/dkx257 Image
Oct 31, 2022 • 6 tweets • 2 min read
#IDtwitter #MedTwitter #Microbiology #AMRrounds
In 1954 [Yale J Biol Med], Bennett and Beeson reported “there is a lag period of about one hour between the time of the sudden influx of bacteria and onset of the rigor, and the blood is often sterile by the time fever begins. Among seven medical centers and 1,436 patients, Riedel et al [J Clin Microbiol. 2008; 46(4): 1381-5] reported “the likelihood of documenting bloodstream infections was not significantly enhanced…at the time patients experienced temperature spikes”