4/ With this editorial we take the NEXT STEP in providing an expert consensus of 10 MD + PhD authors on topic of #LDL in #LMHR on a #ketodiet, including incredibly highly respected members of the Lipidology community authors.elsevier.com/a/1g22A6tb2E2O…
5/ Major take-aways:
A prudent PATIENT-CENTERED clinical approach is required for managing #LMHR patients
The #LMHR phenomenon deserves FURTHER RESEARCH, both on mechanism and risk, and has potential to teach us much about human lipid metabolism and ASCVD
6/ Some of my favorite linesare as follows 👇
"LMHR provide[s] a unique opportunity to understand LDL-c dynamics beyond what has previously been possible”
“where there are competing medical conditions, weighing of treatment options should be an individual matter”
7/ It was a true pleasure to put together this editorial with my coauthors @MichaelMindrum, Dr. Giral, Professor Anatol Kontush, @AdrianSotoMota, @DrRagnar (Tommy Wood), @DominicDAgosti2, Dr. Manubolu, @BudoffMd, and Dr. Ronald Krauss. I cannot speak highly enough of this team
8/ I also want to give a HUGE shout out to the LMHR Facebook group + @realDaveFeldman who collectively helped to fund the open access fee despite being blinded to article itself and purely out of a devotion to open-access science and in moving this particular discussion forward
9/ Also, check out Dave's 2:29 min video here. Always high production quality!
10/ I will have more to say on this editorial in the coming days and weeks, but for now I encourage you to read it for yourself (it's concise!) and help to amplify this important discussion! 🙏🙏🙏 authors.elsevier.com/a/1g22A6tb2E2O…
Anorexia is a devastating condition that increases risk of death >5X and is associated w/ high rates of relapse
There is desperate need for more effective treatment options
3/10) Common knowledge posits patients w/ anorexia should be discouraged from practicing food group restriction
But anorexia can be framed metabo-psychiatric condition that may benefit from treatment w/ metabolic health interventions w/ neuromodulatory properties, i.e. #ketodiet
2/ In this study, normal-weight participants were exposed to EITHER a high-fat/high-sugar snack OR a low-fat/low-sugar snack for 8 weeks in addition to their regular diet. The snacks were to be consumed 2x per day and were isocaloric.
3/ After the intervention, they first tested fat & sugar preferences & found, compared to baseline:
High Fat-Sugar intervention ⬇️ wanting for lowest but also highest fat food
Snacking intervention in general (both high-fat- sugar & low fat-sugar) ⬇️wanting for low sugar food
🚨Carbohydrate insulin model “dead,” OR is it misunderstood again? 🤥
1/ Doctor Tweeted “that the carbohydrate-insulin theory is completely dead” ☠️⚰️
I recently watch the interview with that doctor, and it was surprising the degree to which s/he got the facts wrong…
2/ The CIM does posit that a high glycemic load diet drives high insulin to glucagon ratio state… as a result energy available in the bloodstream is driven downwards in the late postprandial phase leading to “hormonal, hunger” & overeating…
3/ Doc said: “This whole process of fattening all the way down the line, you’ve actually got MORE fuel in your bloodstream… than someone who is not getting fatter.” ... the “decrease EA in the blood "has never been documented because it’s not really there!” Thus, CIM is dead!
1/ How to poo 💩! Was listening to the new @hubermanlab with @DrGottfried this AM (at 3:37) on hormones and #constipation & was inspired to do a little thread on my top #6 tips for dealing with constipation ... hopefully this thread helps at least 1 silent sufferer
2/ This is a topic I'm interested in is bc as someone with a hx of proctitis + cecal patch (form of ulcerative colitis strongly linked to constipation), it's something I've struggled w/ at times. It's not fun & a far more prevalent problem than people realize 4 obvious reasons
3/ Let's start the list.
#1 tip has nothing to do with diet, but technique!
In normal seated position with knees at 90o, your puborectalis muscle strangles your rectum. If you squat with the assistance of a squatty potty (or 'toilet yoga') you receive this strangle-hold
1/4) “Satiety score” score suggest macadamia nuts are more likely to promote weight gain and prevent weight loss than cheesecake?! (higher = more satiety) 🧐
Macadamia = 17
Cheesecake = 19
Battered fried shrimp = 35
Apple juice = 32
Fried zucchini fritters 27
2/4) First, lest address the science. Do macadamia nuts cause weight gain?
In a 4 week interventional trial in which people were instructed to eat 40-90 grams of macadamia there was actually a net weight loss.
Try getting those results with cheesecake…
3/4)
Over past few days, I’ve gotten dozens of messages expressing disappointment in the new satiety scoring system
It’s a reasonable concept at best, but definitely not ready to be available as a public tool if it’s promoting cheesecake and apple juice over raw nuts.