Thread by @OBsleepmerchant

Sawubona @DavidGray37! He’s presenting on Tranexamic acid at cesarean section: Drug Error Deaths. An unforeseen result of Woman trial. Potentially life saving in LMIC, deadly in drug error. Disproportionately #OBAnes in district/ rural settings. TXA a new drug there #OAA3dc2022

A recent situation. Warning from @ArviPalanisamy and Dr Kinsella. A characteristic presentation - unfortunately very similar to eclampsia, in an environment used to poor antenatal care & eclampsia. Both bupivacaine & TXA now generic, no control of similar packaging. #OAA3dc2022

And #lookalike vials are a problem, a BIG one. 7 recent cases in SA only from 2 provinces, 5 fatal & 2 major neurological morbidity. Getting worse, under reported. Guidance provided, it’s own complication though #OAA3dc2022

This is the drug cart, even without TXA it’s a drug error waiting to happen. These cases are occurring in district hospitals, non-dedicated anesthetists. Have deaths been seen with epidural - not yet! Although less likely in rural SA (no epidural kits) #OAA3dc2022