Thread by @rheum_cat

#ACR22 plenary highlights

1️⃣acrabstracts.org/sessions/plena…
2️⃣acrabstracts.org/sessions/plena…
3️⃣acrabstracts.org/sessions/plena…

🌟Abs 0001 Botson, et al.
MIRROR RCT: adding MTX to pegloticase for gout
👉52 wk results: response 60% vs 31% pbo

*response: SU<6mg/dl for >=80% of wks 48-52
#ACR22

Abs 0001 cont'd

👉Also: complete tophi resolution 54% MTX vs 31% pbo at 52 wks

#ACR22

🌟Abs 0003 Maher, et al.
RECITAL RCT: RTX vs CYC for CTD-ILD

👉1* outcome change FVC at 24wks - greatest benefit IIM, MCTD
SSc-ILD: ↔ but not improved

#ACR22

🌟Abs 0004 Mandal, et al @ucsf_rheum
Rheumatology Access Expansion Initiative 👉 Improving RA care in Navajo Nation through PCP education
=12wk training program for PCPs including weekly webinars

Surveys to test knowledge, confidence: 👉demonstrates feasibility, impact

#ACR22

🌟Abs 1115 Silva, et al.
Medication copay modifies tx adherence in pts w SLE
🤔Rationale: copays as barrier to SLE tx adherence

Database: Optum
SLE on HCQ, AZA, MMF

#ACR22

Abs 1115 cont'd

Exposure: copay (high vs low)
Outcome: med adherence (PDC >80%)

Sig associations for each med

👉High med co-pays ➡⬇med adherence in SLE

#ACR22

🌟Abs 1116 Jeffries, et al.
Peripheral blood DNA methylation-based #ML models for knee #OA progression prediction

💻Datasets: FNIH OA Biomarkers Consortion subcohort of OAI & JoCo (validation)

#ACR22

Abs 1116 cont'd

KOA progression defined by: 1) radiography, 2) pain, 3) radiography + pain

👉Based on DNA methylation patterns identified as key predictors, infer that pain & structural progression share similar systemic immune epigenotypes
#ACR22

🌟Abs 1675 Messier, et al.
WE-CAN pragmatic RCT: diet + exercise in individuals with knee OA & overweight/obese BMI

👉Treatment effect seen in prior trials in more ideal settings; this study shows that it works in a community-based setting too

#ACR22

🌟Abs 1678 @TonyMerriman2
GWAS revealing new pathogenic pathways in #gout

👉In addition to known pathways (urate regulation, NLRP3 inflammasome and IL-1), CHIP pathway, insulin signalling pathway identified

#goutology #gouterati
#ACR22