Rheum Cat Profile picture
Nov 11, 2022 13 tweets 10 min read Read on X
Smart move: Having Dan Kastner give the last talk of the #ACR22 #ReviewCourse

I look forward to exciting onomatopoeia
Remind yourself of the features of the innate immune system #ACR22 #ReviewCourse
FMF 101, all on one slide

🧬Mutation: MEFV which encodes the protein pyrin
(#ACRKnowledgeBowl stuff!)

💊colchicine or 💉canakinumab if intolerant/refractory

#ACR22 #ReviewCourse
TRAPS - perhaps best to learn it in contrast to FMF
⚡️longer episodes
⚡️not responsive to colchicine

🧬TNFRSF1A, coding for p55 TNF receptor
💉canakinumab (though steroids effective)

#ACR22 #ReviewCourse
HIDS: a misnomer; 🧬MVK mutation (mevalonate kinase)

💉canakinumab

#ACR22 #Reviewcourse
Cryopyrinopathies:

🧬NLRP3 mutation (protein, cryopyrin)

💉IL 1 inhibitors

#ACR22 #ReviewCourse
"A triumph of molecular medicine": the effective use of IL-1b inhibition in cryopyrinopathies

An erstwhile mentor told me this was a "feel good NIH story"

#ACR22 #ReviewCourse
Now the story of DADA2

protein: adenosine deaminase 2
➡️effects on vascular and myeloid development
➡️hence early onset strokes, livedo, vasculopathy

#ACR22 #ReviewCourse
He's going to end with #VEXAS with the exclamation point

The story involves working backwards: genotype first, rather than collecting cases with similar phenotype

#ACR22 #ReviewCourse
🧬"UBA1 is the mother of all ubiquitin genes"

🔍Curious part of the story: it's encoded on the X chromosome in a disease seen in older men

💡It's a sporadic mutation

#ACR22 #ReviewCourse
"This is fact stranger than fiction!"

🔍odd vacuoles in the myeloid precursor cells in the bone marrow

After discussion with heme path, they found more patients (seen 8 yrs prior) with #VEXAS

#ACR22 #ReviewCourse
Waiting for him to say "VEXAS rhymes with Texas" as he did in a prior presentation

#ACR22 #ReviewCourse

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More from @rheum_cat

Nov 13, 2022
#ACR22 social media talk, very meta
Part 1️⃣: optimize your conference tweeting
If you're reading this you probably know all of this!

The first pro-tip was figure out the conference hashtag
The second? Engage with others in rheum
#ACR22
What else?

👉amplify your group
👉amplify speakers and sessions of interest
👉amplify your colleagues so they will amplify you in turn

#ACR22
Read 10 tweets
Nov 13, 2022
#ACR22 infection (COVID) posters Image
Abs 0784 @CCalabreseDO

Cleveland Clinic breakthrough infections, including data on n=21 who received Evusheld

📌Publication here: pubmed.ncbi.nlm.nih.gov/35791921/

#ACR22
@CCalabreseDO Abs 0779 @CCalabreseDO

Experience with evusheld PrEP with IMID on BCDT at Cleveland Clinic

📌Publication here: pubmed.ncbi.nlm.nih.gov/36123015/

#ACR22
Read 13 tweets
Nov 13, 2022
The EULAR e posters were tiny (bad) but speakers could zoom in and out (good)

That would have been nice for #IgniteTalks #ACR22
The sound is adequate though. EULAR issue was that the sound was poor in their (smaller) poster tour stages #ACR22 #IgniteTalk
Read 4 tweets
Nov 13, 2022
#ACR22 epidemiology posters Image
Abs 0700 @zach_wallace_md
💻Using NLP, ML algorithms to identify ANCA vasculitis cases

They also looked at the difference in performance metrics with/without filtering keywords

An explosion of NLP studies in rheum! #ACR22
@zach_wallace_md Abs 0732 Ho, et al. @JYazdanyMD @MilenaGianfran
💻Part of the explosion of NLP studies in rheum

Here the UCSF group aimed to capture VZV cases (differentiate from vaccination); and to capture active vs historical cases

See their diagrams explaining the steps!
#ACR22
Read 13 tweets
Nov 13, 2022
We have learned quite quickly that a virtual ONLY poster hall mixed into a hybrid meeting doesn't work well.

Poor wifi and the crashing platform compound the problem

And if it's online ONLY, is that truly hybrid?

#ACR22
This is not a complaint thread. I am hoping we can have discussion about what works/doesn't work, and what could be done next year for #ACR23
It goes without saying that an in-person poster hall is the most requested item on the wishlist for #ACR23

@GrantSchulert @Tuhina_Neogi
Read 5 tweets
Nov 13, 2022
Biostatician @MikeLaValley8 @BU_BMC_Rheum presents a quick overview on how to appropriately interpret results from studies #ACR22

Of course this is not an exhaustive deep dive, but covers some common errors of interpretation Image
@MikeLaValley8 @BU_BMC_Rheum First, what is your research question? What is the question you are trying to answer with t he study?

👉Does this exposure CAUSE this outcome?

#ACR22 Image
@MikeLaValley8 @BU_BMC_Rheum What are common observational study designs and what are big issues to watch out for?

These are issues that can affect the validity of their results.

There are more potential issues within these study designs that is beyond the scope of this table

#ACR22 Image
Read 15 tweets

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