Rheum Cat Profile picture
Nov 12, 2022 12 tweets 16 min read Read on X
In the ortho/rehab oral session, which is really an #OA session we have former @bu_bmc_rheum postdoc @kosakuaoyagi now with his own lab at @utep

Presenting his work with @tuhina_neogi: trajectories of pain sensitization in knee OA

#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi What is central pain sensitization?
Altered CNS nociceptive signaling

👉It's present in ~30% of people with knee OA & contributes to the pain experience in OA

#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi There's a lot we don't understand about the pain experience in OA, or about central pain sensitization

📈Patterns in central pain sensitization over time may also vary and influence pain differently
#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Thus the purpose of this study was to agnostically identify central pain sensitization patterns over time and evaluate their associations with pain severity in people with or at risk of knee OA

#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi This study used repeated measures from #MOST over 9 years of follow up

#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Exposure: central pain sensitization measured with PPT at the wrist
(Lower PPT reflects greater sensitivity)

📈Clustering analysis (sex-specific) identified trajectories of central pain sensitization over 9 yrs

#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Outcome: WOMAC pain at the 14th yr follow up

Regression models adjusted for age, sex, BMI, race, clinic site, depressive symptoms, and catastrophizing

#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Results

3️⃣ distinct trajectory groups for women and men:
Stable low PPT
Stable moderate PPT
High and improving PPT

Remember that lower PPT reflects greater sensitivity
#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi The 3 wrist PPT (central pain sensitization) trajectory groups presented separately for women & men

#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Multivariable analysis results for the relation of wrist PPT trajectory group & WOMAC pain at end of f/u

Stable low PPT over a long period of time (i.e., most pain sensitized) was associated with greatest pain severity

#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi These findings highlight that some patterns of PPT remain stable over time, suggesting a TRAIT phenomenon

#ACR22
@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Interested in learning more about TRAIT vs STATE & pain sensitization in knee OA?

@tuhina_neogi's seminal work here: pubmed.ncbi.nlm.nih.gov/24351516/

#ACR22

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More from @rheum_cat

Nov 13, 2022
#ACR22 social media talk, very meta
Part 1️⃣: optimize your conference tweeting
If you're reading this you probably know all of this!

The first pro-tip was figure out the conference hashtag
The second? Engage with others in rheum
#ACR22
What else?

👉amplify your group
👉amplify speakers and sessions of interest
👉amplify your colleagues so they will amplify you in turn

#ACR22
Read 10 tweets
Nov 13, 2022
#ACR22 infection (COVID) posters Image
Abs 0784 @CCalabreseDO

Cleveland Clinic breakthrough infections, including data on n=21 who received Evusheld

📌Publication here: pubmed.ncbi.nlm.nih.gov/35791921/

#ACR22
@CCalabreseDO Abs 0779 @CCalabreseDO

Experience with evusheld PrEP with IMID on BCDT at Cleveland Clinic

📌Publication here: pubmed.ncbi.nlm.nih.gov/36123015/

#ACR22
Read 13 tweets
Nov 13, 2022
The EULAR e posters were tiny (bad) but speakers could zoom in and out (good)

That would have been nice for #IgniteTalks #ACR22
The sound is adequate though. EULAR issue was that the sound was poor in their (smaller) poster tour stages #ACR22 #IgniteTalk
Read 4 tweets
Nov 13, 2022
#ACR22 epidemiology posters Image
Abs 0700 @zach_wallace_md
💻Using NLP, ML algorithms to identify ANCA vasculitis cases

They also looked at the difference in performance metrics with/without filtering keywords

An explosion of NLP studies in rheum! #ACR22
@zach_wallace_md Abs 0732 Ho, et al. @JYazdanyMD @MilenaGianfran
💻Part of the explosion of NLP studies in rheum

Here the UCSF group aimed to capture VZV cases (differentiate from vaccination); and to capture active vs historical cases

See their diagrams explaining the steps!
#ACR22
Read 13 tweets
Nov 13, 2022
We have learned quite quickly that a virtual ONLY poster hall mixed into a hybrid meeting doesn't work well.

Poor wifi and the crashing platform compound the problem

And if it's online ONLY, is that truly hybrid?

#ACR22
This is not a complaint thread. I am hoping we can have discussion about what works/doesn't work, and what could be done next year for #ACR23
It goes without saying that an in-person poster hall is the most requested item on the wishlist for #ACR23

@GrantSchulert @Tuhina_Neogi
Read 5 tweets
Nov 13, 2022
Biostatician @MikeLaValley8 @BU_BMC_Rheum presents a quick overview on how to appropriately interpret results from studies #ACR22

Of course this is not an exhaustive deep dive, but covers some common errors of interpretation Image
@MikeLaValley8 @BU_BMC_Rheum First, what is your research question? What is the question you are trying to answer with t he study?

👉Does this exposure CAUSE this outcome?

#ACR22 Image
@MikeLaValley8 @BU_BMC_Rheum What are common observational study designs and what are big issues to watch out for?

These are issues that can affect the validity of their results.

There are more potential issues within these study designs that is beyond the scope of this table

#ACR22 Image
Read 15 tweets

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