Thread by @rheum_cat

In the ortho/rehab oral session, which is really an #OA session we have former @bu_bmc_rheum postdoc @kosakuaoyagi now with his own lab at @utep

Presenting his work with @tuhina_neogi: trajectories of pain sensitization in knee OA

#ACR22

@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi What is central pain sensitization?
Altered CNS nociceptive signaling

👉It's present in ~30% of people with knee OA & contributes to the pain experience in OA

#ACR22

@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi There's a lot we don't understand about the pain experience in OA, or about central pain sensitization

📈Patterns in central pain sensitization over time may also vary and influence pain differently
#ACR22

@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Thus the purpose of this study was to agnostically identify central pain sensitization patterns over time and evaluate their associations with pain severity in people with or at risk of knee OA

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@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi This study used repeated measures from #MOST over 9 years of follow up

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@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Exposure: central pain sensitization measured with PPT at the wrist
(Lower PPT reflects greater sensitivity)

📈Clustering analysis (sex-specific) identified trajectories of central pain sensitization over 9 yrs

#ACR22

@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Outcome: WOMAC pain at the 14th yr follow up

Regression models adjusted for age, sex, BMI, race, clinic site, depressive symptoms, and catastrophizing

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@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Results

3️⃣ distinct trajectory groups for women and men:
Stable low PPT
Stable moderate PPT
High and improving PPT

Remember that lower PPT reflects greater sensitivity
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@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi The 3 wrist PPT (central pain sensitization) trajectory groups presented separately for women & men

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@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Multivariable analysis results for the relation of wrist PPT trajectory group & WOMAC pain at end of f/u

Stable low PPT over a long period of time (i.e., most pain sensitized) was associated with greatest pain severity

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@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi These findings highlight that some patterns of PPT remain stable over time, suggesting a TRAIT phenomenon

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@BU_BMC_Rheum @KosakuAoyagi @UTEP @Tuhina_Neogi Interested in learning more about TRAIT vs STATE & pain sensitization in knee OA?

@tuhina_neogi's seminal work here: pubmed.ncbi.nlm.nih.gov/24351516/

#ACR22