1/4 New research journal "Brain" identifies a way to increase clearance of waste products from the brains of mice by ramping up a genetic quirk known as "Readthrough"
2/4 Every once in a while, the protein aquaporin 4 is synthesized with a little tail on the end
Interestingly, this expression pattern occurs only in structures that are important for waste clearance
3/4 Long aquaporin 4 can be found in the end feet of brain support cells called "astrocytes" that wrap around blood vessels in the brain and help regulate blood flow and improve waste clearance of amyloid found in #Alzheimers ...
4/4 Interestingly, in the mice, "apigenin," a dietary flavone found in chamomile, parsley, onions increased the Acuaporin 4, and mice treated w/ apigenin cleared amyloid beta significantly faster
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1/ Highlighting the strawman &loose associations bw diet &othr beliefs is a standard tactic 2 get clicks and rile the base
But you'd think this fellow would have insight not to TW this fluff directly after we published an editorial refuting his claims sciencedirect.com/science/articl…
2/ I don't have an issue if one wants to make a counterpoint to a direct claim
But all he's doing by pulling out the broad brush and capitalizing on stereotypes is exacerbating pre-existing polarizations and thus undermining efforts to engage in productive & educational dialogue
3/ Also pitiful when a medical "professional" feels the need to make himself a joke and brand-build by consistently targeting a dietary pattern
Might the evidently many hours spent teasing others be better spent on trying to write something productive?
2/ in the largest prospective trial to date (WHS, median follow-up was 21.4 years. N=28 024 women aged >45 years). LP-IR had an adjusted hazards ratio of 6.4 for coronary disease, as compared to 4.3 for obesity 3.9 for smoking and only 1.3 for LDL-C.
3/ in other words, there was ~ 540% increase in coronary disease risk with insulin resistance but only ~30-40% for LDL-C. Furthermore, there was likely an interaction between terms as the association didn’t hold for large LDL but was driven by small LDL, which is associated w/ IR
1/ Have you seen the New Non-Nutritive sweeteners paper in Cell making the rounds!?! Fantastic!
Here's a video rundown:
And this thread contains a brief tweetorial...
2/ This study took 120 young health people who didn't consume non-nutritive sweeteners (NNS) and broke them into 6 groups, n = 20/group
👉 Control (no supplement)
👉 Glucose
👉 Sacchrin
👉 Sucralose
👉 Aspartame
👉 Stevia
7 day baseline, 14 day exposure, and 7 day follow-up
3/ There was a clear individualized response across NNS, with Sucralose and Saccharin having the largest impact on glucose tolerance on oral glucose tolerance test.
There were "responders" (who had worse glucose tolerance in response to NNS) and also non-responders.