Thread by @Pathology_mcqs

A 65 year old male presented with low urine output and bone pain. On further investigation serum creatinine was high and the patient had low hemoglobin. Bone marrow biopsy showed finding in the image. What is your diagnosis? #pathtwitter #pathtweetorial #pathresidents #pathboards

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Answer is multiple myeloma.
The image shows "INTRA-NUCLEAR INCLUSIONS" called "DUTCHER BODIES".
They are deposits of immunoglobulins. Intracytoplasmic immunoglobulin inclusions are called RUSSEL BODIES.
Seen in multiple myeloma, plasmacytoma, lymphoplasmacytic lymphoma (LPL).

Dutcher bodies are

Dutcher bodies are true inclusions.
True inclusions are due to deposition of substances such as immunoglobulins or viral particles, whereas pseudoinclusions are cytoplasmic invaginations
Image credit: mobile.twitter.com/megothelioma

Identify the odd man out ( All conditions mentioned below are true nuclear inclusions-except?)

Answer is Meningioma.
Intranuclear inclusions Seen in meningioma are "PSEUDO-INCLUSIONS"
Some conditions showing nuclear true inclusions are summarized in the images below.

Last one on this topic.
Which tumor has characteristic intranuclear pseudo- inclusions?

Answer is all
Image shows some common tumors showing intranuclear inclusions.

Have you heard of pseudo-pseudo inclusions???
If you haven't, find out about it and leave a comment.
Thanks for staying!!