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Luminary #1: Sarah McNutt (1839-1930)
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In 2002, Horn and Goetz published this excellent paper on McNutt - the 1st woman elected to the American Neurological Association (@TheNewANA1) - and her work with other early female physicians, including the Blackwells. n.neurology.org/content/59/1/1… 2/🪑
McNutt came from a long line of female midwives and healers, including Sarah Weir, who worked on Nantucket, and Rachel Hussey, who delivered 2992 children (both called physicians here, but neither MDs) 3/🪑
McNutt worked as a principal and a teacher before she attended the Women's Medical College of the New York Infirmary from Women and Children - an institution founded by Elizabeth and Emily Blackwell as a place to teach, employ, and take care of women 4/🪑
(If you've seen my talk on historical women neurologists, you know I like to compare the picture of the Women's Medical College - a room of women, examining a male body - with this painting of Charcot teaching to a room of men at the Salpêtrière.) 5/🪑
Elizabeth Blackwell was the 1st woman to get an MD in the US. In 1921, almost 10 yrs after her death, McNutt wrote a reminiscence on Blackwell: "one of the most vivacious women I had ever met," "charming in manner, likable and above all perfectly human." 6/🪑
McNutt worked at the Women's Medical College: as an instructor in gynecology, then assistant in general surgery, then in the Children’s Department (11 years), and then in the Gynecological Department (19 years).
In her free time, she studied neuropathology. 7/🪑
In 1884, she presented a paper at the 10th @TheNewANA1 meeting, on the neuropathology of a 2.5 yo girl with bilateral spastic hemiplegia after a difficult birth. 8/🪑
@TheNewANA1 was created as a prestigious organization for no more than 50 of the top neurologists. McNutt's election was impressive. Charles K. Mills, president in 1886, reminisced later that she presented "one of the earliest contributions" to the study of cerebral palsy. 9/🪑
Gowers' biographer Critchley wrote that he was not "a rabid misogynist" (phew) but felt McNutt's work was "by far the most valuable contribution to medical science that the profession has yet received from its members of her sex.” 10/🪑
Osler - who coined the term cerebral palsy - cited McNutt's work in his book The Cerebral Palsies of Children. 11/🪑
She continued to publish articles on neuropathology, but left @TheNewANA1 in 1902 "owing to the stress of a busy life and the inability to attend the meetings." The next female member would be neuropsychologist Lauretta Bender, more than 30 years later. 12/🪑
Instead, she joined her physician sister Julia McNutt and other physicians Jeannie Smith, Isabella Satherthwaite and Isabella Banks to found the 1st pediatric hospital in NYC: the Babies' Hospital. 13/🪑
McNutt never married, but lived with or near her sister Julia for most of her life.
What was she like? From her passport application in 1896, we can see that she was 5'2", grey-eyed and brown haired (slightly grey at 56), with a round chin and an average mouth. 14/🪑
This (weird) article from 1898 argues that city women look younger, prettier and healthier than country women, who eat a diet of "pastry and pickles." It describes McNutt as "charming," "interesting," and suggests that she is also attractive. 15/🪑
She says in one article that she didn't experience much opposition from men as a female physician - but here she is in the 1912 @nytimes announcing that men are to blame for the problem with women these days (not having enough babies). 16/🪑
McNutt died in 1930 at the age of 91. 17/🪑
I have never seen it explicitly stated that Sarah McNutt didn't have a brain tat on her bicep, or Queen Square hammer earrings. WHO KNOWS.
Read more about Dr. McNutt and 11 other exceptional women from the history of neurology at EndowedChairs.com! 🪑/🪑
Isabelle Rapin is the perfect Luminary to discuss today, because she was born December 4🎂and was a founding member of the @ChildNeuroSoc in 1973 in #Nashville (where everyone is going for #AES2022).
Peds neurologists know why she has a pinwheel on her card - do you? 2/🪑
Born in Lausanne, Switzerland - where Augusta Déjerine-Klumpke studied - Rapin went to medical school locally. Like ADK, she worked at the Salpétrière - and like ADK, she wrote a brief autobiography (please write one, send to @JChildNeurol) journals.sagepub.com/doi/10.1177/08… 3/🪑
Happy birthday (November 29) to the Father of Neurology, Jean-Martin Charcot (1825-1893)!
I wouldn't say we're best friends exactly, but yeah, we used to hang out in Paris together. 1/4
Charcot was a neurologist in Paris in the late 1800s, when neurology was developing as a field. He was the 1st chair of neurology, and was a celebrity doctor at the time (this is a poem written and published in the newspaper after his death in 1893). 2/8
He was so famous that charlatans used his name after his death to sell "Kola Nervine Tablets" made from the "wonder-working Kola nut." 3/8
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Luminary #4: Dorothy Russell (1895-1983)
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Hands up if you used this textbook! The 7th edition of "R&R" was published in 2007.
You may have known that this was written by eminent neuropathologist Dorothy Russell, but did you know she had epilepsy? 2/🪑
Russell was born in Australia, but after both her parents died (her mother from measles), Dorothy and her sister Petronella went to live in England with an aunt. 3/🪑
Edwin Smith, born in Connecticut, lived in Egypt in the late 1800s. An antiquities dealer, he bought a papyrus in 1862 that he was unable to translate.
Smith died in 1906, and his daughter donated the scroll to the New York Historical Society.
In 1920, Egyptologist Caroline Ransom Williams found it and recognized its worth. She wrote to her mentor James Henry Breasted and asked him to translate it. brewminate.com/the-contributi…
Ransom Williams felt she was too occupied with family to take it on.
“The papyrus is probably the most valuable one owned by the Society and I am ready to waive my interest in it, in the hope that it may be published sooner and better than I could do it.” [November 22, 1920]
Bradford-Hill's trial of streptomycin for TB (see my thread from earlier today) was the first randomized controlled trial - but not blinded, and not placebo controlled. There was another trial, around the same time, for a medication called patulin. 1/6
You've never heard of patulin? It's a mycotoxin (it grows on apples), once used as an antibiotic (but not any more, due to toxicity).
In the 1940s, it was billed as the cure for the common cold. 2/6
A study showed that if you spray patulin in someone's nose when they have a cold, they feel much better - within 48 hours - than people who didn't receive any treatment.
This was huge! Everyone wanted patulin to treat colds.
So what happened? 3/6
Here’s a good story about the placebo effect – on physicians:
If you had a stroke in 1810, it would have been diagnosed clinically, without MRI. Your doctors knew that if you died, your brain held either fluid (edema, ischemic stroke) or blood (hemorrhagic stroke). 1/
So obviously the problem was that there was too much fluid in your body.
Solution? Reduce fluid, by blood-letting. This was the solution to a lot of things (one of these days I'll do a #histmed#tweetorial on Benjamin Rush).
And many people got better. 2/
People got better because when you have a small stroke, inflammation and edema make symptoms worse initially, and then, over time, symptoms improve.
If they didn't get better? Easy - you didn't bleed them enough. 3/