#IDTwitter #SIDPharm #Microbiology
#AMRrounds called about this microbiology confirmed isolate and susceptibility results (AMR Step 1) associated with a clinically confirmed infection (Clinical ID Step 1) inquiring about AMR and treatment options.
#AMRrounds called about this microbiology confirmed isolate and susceptibility results (AMR Step 1) associated with a clinically confirmed infection (Clinical ID Step 1) inquiring about AMR and treatment options.
AMR Step 2: Understanding natural (intrinsic) mechanisms of resistance.
Outer membrane protein A of A baumannii (AbOmpA) attributed to intrinsic resistance through interaction of OmpA-like domain and efflux pump. DOI: 10.1093/jac/dkx257
Outer membrane protein A of A baumannii (AbOmpA) attributed to intrinsic resistance through interaction of OmpA-like domain and efflux pump. DOI: 10.1093/jac/dkx257
AMR Step 3: Understanding local, regional, and global AMR
Example from the ARLN surveillance data, 69% (n=27) CP-CRAB harbored NDM and 31% (n=12) harbored KPC but carbapenemase genes detected in <1% isolates (n=39/4,491).
Example from the ARLN surveillance data, 69% (n=27) CP-CRAB harbored NDM and 31% (n=12) harbored KPC but carbapenemase genes detected in <1% isolates (n=39/4,491).
AMR Step 4: Understanding mechanisms of acquired resistance.
Example from DOI: 10.1080/1120009X.2020.1847421 (also PBP modification).
Example from DOI: 10.1080/1120009X.2020.1847421 (also PBP modification).
Therapeutic options.
IDSA has provided guidance on potential options at idsociety.org/practice-guide…
IDSA has provided guidance on potential options at idsociety.org/practice-guide…
Question:
Your approach to these infections at your center [if available agent(s)] would be (AAC antibiotic abbreviations):
Your approach to these infections at your center [if available agent(s)] would be (AAC antibiotic abbreviations):
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