Thread by @scottisaacsmd

Bart Staels, PhD of Univ of Lille, France gave an outstanding talk on Interplay Between #NAFLD & #CVD at the #WCIRDC. CVD is the leading cause of death not liver disease. Fibrosis severity correlates with higher CVD risk. @WCIRDC @YHandelsmanMD
healio.com/news/endocrino…

Type 2 #diabetes and #NAFLD have a reciprocally injurious relationship mediated through common pathophysiology magnifying the risk for #CVD events.
pubmed.ncbi.nlm.nih.gov/33015726/ @zilbermint @AlinaAllenMD

#NAFLD is considered the hepatic manifestation of the metabolic syndrome and is closely linked to:
✅#Obesity, especially visceral adiposity
✅Insulin resistance
✅Chronic inflammation
✅#Lipotoxicity
nature.com/articles/s4141…

NAFLD is associated with an especially atherogenic #dyslipidemia and milieu for #CVD:
✅↑ VLDL
✅Hypertriglyceridemia
✅Small dense LDL
✅↓ HDL
✅Endothelial dysfunction
✅Prothrombotic state
sciencedirect.com/science/articl…

The leading cause of death in patients with NAFLD is #CVD, not liver disease. The increased risk of both fatal and nonfatal CV events in #NAFLD and #NASH has been correlated with the severity of hepatic steatosis, inflammation, or fibrosis. @TheAACE
sciencedirect.com/science/articl…

In #NAFLD, more severe liver disease increases #CVD risk. Both CV and liver events are highly related to the degree of hepatic fibrosis. @EndocrineToday @AlkhouriNaim @DrLoomba @NoureddinMD @Mayo_liverdoc
healio.com/news/cardiolog…

The FIB-4 score predicts #CVD risk in #NAFLD, patients with high FIB-4 have a 4-fold increased risk.
pubmed.ncbi.nlm.nih.gov/31887443/ @DrKarlNadolsky @DrNadolsky @rabataller @FattyLiverA @LiverSaver

#CVD and #Obesity
✅Atrial fibrillation
✅Ventricular arrhythmias
✅Heart failure with preserved ejection fraction
✅Cardiomyopathy
✅Cardiac fibrosis
✅Cardiac valvular calcification
pubmed.ncbi.nlm.nih.gov/36007112/
@BevTchangMD @monicaagar21 @JaimeAlmandoz @ErinMichos

It is difficult to establish a causal relationship between #NAFLD and #CVD, given the entanglement of overlapping metabolic disturbances in these individuals. @EndocrineToday @TheAACE #livertwitter #endotwitter #CardioTwitter
healio.com/news/cardiolog…