Thread by @remissionbiome

Hi👋🏼This account is run by Tamara @chydrorina + Tess @ales_frost. We’re scientists+patients (yes, you can be both!), who improved from severe #MECFS after taking antibiotics

Our aim w/ #remissionbiome is to look at how modifying the microbiome can shift a person w/ME’s baseline

The idea for #remissionbiome came from both of us experiencing temporary remission, after taking a mix of antibiotics (& in Tamara’s case, probiotics). While remission was fleeting, afterwards, our baselines improved.

Our aim is to recreate this event + understand it.

We will take AmoxClav, probiotics, prebiotics, postbiotics, & exogenous ketones during our experiment.

Before, during (if a remission event happens), & after we will test with @biomesight @ProdromeScience @imyoohealth & some blood tests like TNF alpha, CMP, CBC

There are many possible hypotheses for what might have happened during our temporary remission events, but many follow: Change in gut → mass neuroglia homeostatic event → sudden ⏬ in sickness response

We are continually adding ideas to this graphic: tinyurl.com/37up776m

While we both only experienced short-term remissions (2 days for Tess & 4 hours for Tamara), we experienced an⏫ in baseline function that was very significant. Tamara went from Severe to Moderate (bedridden to walking) & Tess went from Severe/Moderate to Moderate/Mild.

While temporary remission is the immediate goal, it is not the ultimate goal: which is a lasting shift in baseline function, one that might even be kicked up a notch a few times with repeated temporary remissions.

(Thanks to @winstoncb for creating this graphic for us!)

Read more about our experiences here: tinyurl.com/yyj4yj4v

Want to get involved? We’d love more people to join us in this experiment! DM us if you’d like more info.

(We've been blown away by people helping us. 🙏 to @NataliaHodgins for helping to put together this thread!)