Daniel Gewolb, MD Profile picture
Dec 16, 2022 3 tweets 2 min read Read on X
78 yr old with encephalopathy and seizure. MRI shows vasogenic edema within the left temporal and occipital white matter with subcortical extension. SWI shows characteristic lobar micro-hemorrhages predominantly in the effected regions.
#Neurology #neuroradiology #radres ImageImageImageImage
Ddx:
PML
Inflammatory amyloid angiopathy
PRES
Amyloid-related imaging abnormalities (ARIA)
Answer: Inflammatory amyloid angiopathy

This can be indistinguishable from amyloid-related imaging abnormalities (ARIA) seen in patients undergoing treatment for Alzheimer’s disease. Therapies include:

bapineuzumab, solanezumab and aducanumab

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More from @daniel_gewolb

Nov 15
60 y/o F presents w/ several months of confusion, word finding difficulty & gait dysfunction

🔷What is your best guess and differential?

🔷More images in 🧵
#MedEd #radiology #Neurology #radres #neurosurgery #medicine #ENT #Ophthalmology #futureradres Image
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🔷More images 👇 Image
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Answer: Glioblastoma on pathology

🔷Imaging: Tumor, high grade glioma vs lymphoma

🔷This case of glioblastoma is not classic and has overlapping features with lymphoma
Read 11 tweets
Aug 31
Difficult case, let’s run this together. 70 y/o M w/ Hx of HTN presents with acute confusion, dysarthria and facial droop

Images in 🧵

#Neurology #neurosurgery #MedEd #medicine #radres #ENT #futureradres


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🔷First thing we notice is hemorrhage in the left basal ganglia

🔷Classically, hemorrhage in the basal ganglia in an adult with hypertension we think of hypertensive hemorrhage but the morphology does not match here Image
🔷The hemorrhage is confined to the gray matter so right now we should be thinking stroke with hemorrhagic transformation

🔷However, the mass effect seems disproportionate to the amount of hemorrhage and with relative preservation of the gray white differentiation 🤔 Image
Read 10 tweets
Jun 4
What is the most likely diagnosis in this 20 y/o M presenting w/ seizure, weakness, AKI & hypertension?

CT in 🧵

#meded #neurology #neurosurgery #FOAMed #neurorad #ENT @AlbanyMedRadRes #medicine


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CT 👇 Image
Answer: Acute hypertensive encephalopathy (PRES) w/ superior frontal sulcus pattern

🔷Typically, when we see and think of PRES we think of the dominant parietal-occipital pattern but it’s important to be aware of other less well known patterns
Read 5 tweets
May 8
Distinguishing between pathologic & compression fractures can be difficult

Here are some tips to help in 🧵

#Neurosurgery #MedEd #medicine #neurology #radres #futureradres


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🔷Some findings more suggestive of pathologic fracture:

1️⃣Other spinal mets Image
2️⃣Epidural mass, especially when encasing the cord

3️⃣Focal paraspinal mass (beware, sometimes hematoma in compression fracture can mimic paraspinal mass)
Read 8 tweets
Mar 23
Neuroimaging checklist for the patient with Temporal Lobe Epilepsy (TLE) 🧠 ✅

Credit to the excellent talk on the @TheASNR fellowship curriculum given by @EMiddlebrooksMD for inspiration on this topic

#MedEd #medicine #radres #Neurology #Neurosurgery #futureradres


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1.Encephalomalacia (usually from old infarct, trauma, etc.)
2.Mesial Temporal Sclerosis
3.Sphenoid encephaloceles
4.Prominent arachnoid pits (may be encephalocele precursors)
5.Temporal lobe epilepsy with Amygdala enlargement
6.Focal Cortical Dysplasia
7.Polymicrogyria
8.Gray matter heterotopia
9.Tumors
10.HSV encephalitis
11.Autoimmune encephalitis
12.Hypothalamic hamartoma
13.Other infections (NCC, TB, etc.)
14.Incomplete hippocampal inversion (uncertain significance)
15.Others, please add 🙏
Read 20 tweets
Feb 2
What is the most likely diagnosis in this 70 y/o w/ history of pontine infarct ~8 months ago now presenting with worsening ataxia and dysmetria?

#MedEd #radres #Neurology #neurosurgery #futureradres #Radiology


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Answer (probable): Wallerian degeneration of the pontocerebellar fibers

🔷I only have 1 time point w/o follow up nor images of the pontine infarct. This patient also had cirrhosis. It is possible that the tracts have degenerated due to hepatic encephalopathy or other process
🔷Regardless of the cause in this case, it is important to be aware of these fiber tracts and their appearance when degenerated. Additionally, many other diagnoses can look similar and involve the bilateral middle cerebellar peduncles w/ differential in 🧵
Read 14 tweets

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