78 yr old with encephalopathy and seizure. MRI shows vasogenic edema within the left temporal and occipital white matter with subcortical extension. SWI shows characteristic lobar micro-hemorrhages predominantly in the effected regions. #Neurology#neuroradiology#radres
This can be indistinguishable from amyloid-related imaging abnormalities (ARIA) seen in patients undergoing treatment for Alzheimer’s disease. Therapies include:
bapineuzumab, solanezumab and aducanumab
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Answer: Acute hypertensive encephalopathy (PRES) w/ superior frontal sulcus pattern
🔷Typically, when we see and think of PRES we think of the dominant parietal-occipital pattern but it’s important to be aware of other less well known patterns
Answer (probable): Wallerian degeneration of the pontocerebellar fibers
🔷I only have 1 time point w/o follow up nor images of the pontine infarct. This patient also had cirrhosis. It is possible that the tracts have degenerated due to hepatic encephalopathy or other process
🔷Regardless of the cause in this case, it is important to be aware of these fiber tracts and their appearance when degenerated. Additionally, many other diagnoses can look similar and involve the bilateral middle cerebellar peduncles w/ differential in 🧵