Clinical history is key here as there is an association with ipilimumab. Helpful clues on imaging include a thickened non tapered pituitary stalk with bulbous enlargement of the gland though usually no significant widening of the sella
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Answer: Acute hypertensive encephalopathy (PRES) w/ superior frontal sulcus pattern
🔷Typically, when we see and think of PRES we think of the dominant parietal-occipital pattern but it’s important to be aware of other less well known patterns
Answer (probable): Wallerian degeneration of the pontocerebellar fibers
🔷I only have 1 time point w/o follow up nor images of the pontine infarct. This patient also had cirrhosis. It is possible that the tracts have degenerated due to hepatic encephalopathy or other process
🔷Regardless of the cause in this case, it is important to be aware of these fiber tracts and their appearance when degenerated. Additionally, many other diagnoses can look similar and involve the bilateral middle cerebellar peduncles w/ differential in 🧵