1/🧵Can a Diabetes drug prevent Long COVID?
Most solid data yet of a medication preventing #LongCOVID from quadruple blinded, non-pharma sponsored COVID-OUT trial N=1,125.
A 42% relative ⬇️ in clinician diagnosed LC was seen (10.6% down to 6.3%).
bit.ly/3jvvKj4
Most solid data yet of a medication preventing #LongCOVID from quadruple blinded, non-pharma sponsored COVID-OUT trial N=1,125.
A 42% relative ⬇️ in clinician diagnosed LC was seen (10.6% down to 6.3%).
bit.ly/3jvvKj4
2/ Metformin’s success (1 LC prevented for every 23 pts treated) could save millions from suffering.
<$1 per course = very cost effective.
Too good to be true? Maybe but very solid science.
Let me unpack a bit more…
bit.ly/3jvvKj4
<$1 per course = very cost effective.
Too good to be true? Maybe but very solid science.
Let me unpack a bit more…
bit.ly/3jvvKj4
3/ This trial had 6 groups of patients because 3 meds (metformin/fluvoxamine/ivermectin) were randomized vs. placebo.
The other drugs showed no benefit toward Long COVID reduction.
Metformin also looked good for Acute COVID.
The other drugs showed no benefit toward Long COVID reduction.
Metformin also looked good for Acute COVID.
4/ In COVID-OUT, Metformin showed a similar effect on the acute early primary outcome w a 42% reduction (OR=0.58, 95% CI 0.35 to 0.94) in prevention of ED visits, hospitalizations, or death due to Covid and hospitalizations or death (OR 0.47, 95% CI 0.20 to 1.11) through Day 14.
5/ Definition: Long Covid @ 10 months was a pre-specified outcome in COVID-OUT.
LongCOVID Dx made by medical providers who rendered each diagnosis. And patients consented to medical record review for confirmation of these diagnoses. (so not just self-report as in many studies)
LongCOVID Dx made by medical providers who rendered each diagnosis. And patients consented to medical record review for confirmation of these diagnoses. (so not just self-report as in many studies)
6/ Mechanism of Metformin in LONG COVID?
📍Anti-inflammatory
📍Human lung cells metformin restores autophagy
📍Inhibits release of interleukin-1𝛽 & interleukin-18
Metformin also prevented senescent (aging) phenotype induced by COVID
⁉️reduce cognitive aging in LongCOVID.
📍Anti-inflammatory
📍Human lung cells metformin restores autophagy
📍Inhibits release of interleukin-1𝛽 & interleukin-18
Metformin also prevented senescent (aging) phenotype induced by COVID
⁉️reduce cognitive aging in LongCOVID.
7/ Aging of Dopamine Neurons in COVID
In this study, metformin showed promise at reducing aging of neurons, which if confirmed might help future prevention of Long COVID brain dysfunction.
bit.ly/3Il9mn1
In this study, metformin showed promise at reducing aging of neurons, which if confirmed might help future prevention of Long COVID brain dysfunction.
bit.ly/3Il9mn1
8/fin
📌 This prevention study doesn’t mean metformin will help TREAT #LongCOVID. That is a completely separate issue
📌 These are solid data about prevention that must be replicated
📌 People are desperate but they should NOT start taking metformin until we know more
Stay tuned
📌 This prevention study doesn’t mean metformin will help TREAT #LongCOVID. That is a completely separate issue
📌 These are solid data about prevention that must be replicated
📌 People are desperate but they should NOT start taking metformin until we know more
Stay tuned
💥 Adding Vaxx point from authors @boulware_dr & @BramanteCarolyn - TY for your excellent science!
People who were vaccinated against Covid & who took #metformin had less #longCovid 10 months later👇
Another reason to get your bivalent booster.
People who were vaccinated against Covid & who took #metformin had less #longCovid 10 months later👇
Another reason to get your bivalent booster.
https://twitter.com/boulware_dr/status/1607064304003551236
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