Discover and read the best of Twitter Threads about #metformin

Most recents (4)

(1/) An update of analysis of Dr. Raoult’s #hydroxychloroquine #azithromycin trial on 1061 patients.
(warning: it’ more like conspiracy theory)
(2/) Actually the preprints have two versions.

“Version 2”…

Final version…

There're minor changes in the final version compared to v2. Most are Ct values and HCQ serum concentrations. Other baseline characteristics are the same.
(3/) Another difference is the way that NEWS scores were presented.

Version 2. Mean-Sd-median-range.

Final version. Low-medium-high brackets.
Read 12 tweets
Insulin is NOT a first choice medicine in type 2 diabetes mellitus (T2DM).

- Short-term use in #T2DM:
(1) ketosis
(2) sepsis
(3) extremely high blood glucose
- Long-term use in #T2DM:
(4) secondary oral medication failure (also called ß-cell failure)

The guideline chart attached above is very clear - lifestyle modifications should be the first choice ± #metformin. Metformin is cheap.
I am least influenced by industry, and use long-term insulin in <5% T2DM, mostly for reason (4), usually after exhausting other options.

Those <5% are at a secondary level care hospital, and not at primary care. In primary care, that number will be even lower.

For those who NEED, both biphasic insulin and glargine are available in @pmbjpbppi #JanAushadhi kendras too. Insulin is quite inexpensive there.

Read 7 tweets
98/ #Alzheimers Review #3 of The End of Alzheimers
#VitaminE for AZ?
Not much evidence for it despite what Dale Bredesen writes.…
I would not advise getting the lab test or taking the vitamin.
99/ #Alzheimers Review #4 of The End of Alzheimers
I listed most of the cases sited in Bredesen book.
They are interesting.…
100/ #Alzheimers Review #5 of the End of Alzheimers
In this critical review from WebMD
the supplement advice seems to be the weakest link of the book…
Read 30 tweets
💥Current American Diabetes Association guidelines recommend Metformin as the 1st line therapy for all T2DM patients👇🏽
⚡️But should Metformin be the 1st line therapy in T2DM patients with cardiovascular disease?
💥Let’s review the following about

⚡️Mechanism of action
⚡️Safety profile
⚡️Cardiovascular benefits
💥How does Metformin work?

⚡️It inhibits gluconeogenesis in the liver by mitochondrial inhibition & by ⬆️ activation of AMP-kinase👇🏽
⚡️It ⬆️ insulin sensitivity
⚡️It may have additional pleiotropic
Read 12 tweets

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