Discover and read the best of Twitter Threads about #metformin

Most recents (4)

(1/) An update of analysis of Dr. Raoult’s #hydroxychloroquine #azithromycin trial on 1061 patients.
mediterranee-infection.com/pre-prints-ihu/
(warning: it’ more like conspiracy theory)
(2/) Actually the preprints have two versions.

“Version 2”
mediterranee-infection.com/wp-content/upl…

Final version
mediterranee-infection.com/wp-content/upl…

There're minor changes in the final version compared to v2. Most are Ct values and HCQ serum concentrations. Other baseline characteristics are the same.
(3/) Another difference is the way that NEWS scores were presented.

Version 2. Mean-Sd-median-range.

Final version. Low-medium-high brackets.
Read 12 tweets
Insulin is NOT a first choice medicine in type 2 diabetes mellitus (T2DM).

Exceptions:
- Short-term use in #T2DM:
(1) ketosis
(2) sepsis
(3) extremely high blood glucose
- Long-term use in #T2DM:
(4) secondary oral medication failure (also called ß-cell failure)
@sambit_dash

1.
The guideline chart attached above is very clear - lifestyle modifications should be the first choice ± #metformin. Metformin is cheap.
I am least influenced by industry, and use long-term insulin in <5% T2DM, mostly for reason (4), usually after exhausting other options.

2.
Those <5% are at a secondary level care hospital, and not at primary care. In primary care, that number will be even lower.

For those who NEED, both biphasic insulin and glargine are available in @pmbjpbppi #JanAushadhi kendras too. Insulin is quite inexpensive there.

3.
Read 7 tweets
98/ #Alzheimers Review #3 of The End of Alzheimers
#VitaminE for AZ?
Not much evidence for it despite what Dale Bredesen writes. meandgin.blogspot.com/2019/10/review…
I would not advise getting the lab test or taking the vitamin.
99/ #Alzheimers Review #4 of The End of Alzheimers
I listed most of the cases sited in Bredesen book.
They are interesting.
meandgin.blogspot.com/2019/10/review…
100/ #Alzheimers Review #5 of the End of Alzheimers
In this critical review from WebMD
the supplement advice seems to be the weakest link of the book
meandgin.blogspot.com/2019/10/review…
Read 30 tweets
💥Current American Diabetes Association guidelines recommend Metformin as the 1st line therapy for all T2DM patients👇🏽
⚡️But should Metformin be the 1st line therapy in T2DM patients with cardiovascular disease?
1/
#Metformin
#endotwitter
#cardiotwitter
💥Let’s review the following about
Metformin:

⚡️Mechanism of action
⚡️Safety profile
⚡️Cardiovascular benefits
2/
💥How does Metformin work?

⚡️It inhibits gluconeogenesis in the liver by mitochondrial inhibition & by ⬆️ activation of AMP-kinase👇🏽
⚡️It ⬆️ insulin sensitivity
⚡️It may have additional pleiotropic
effects👇🏽
3/
Read 12 tweets

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