1/ Trepanning:
-oldest known procedure carried out on mankind
-8-10k years old skulls with evidence of medical intervention (found in 🇪🇺, Africa, Asia, New Guinea, Tahiti, New Zealand)
-for headaches, mentalities
-many "patients" survived (evidence of healing of their bones)
2/ Celsus (c. 25 BC - c. 50 AD):
-described "trephination"
-recommended it for removal of damaged cranial bones and as a therapeutic measure for relieving headaches
-with a specialized instrument, a surgical modiolus or crown trephine
-encyclopedia "De medicina" before 47 CE
3/ Trepanation was kept for skulls, even during Renaissance.
The most famous portraits of trephining in mental illness probably come from the beginning of the Flemish Renaissance.
The Cure for Madness (or Folly) by Hieronymus Bosch’s 👇
4/ 1700s:
-"crown trephines" used for therapeutic measures but not for diagnostic use
-similar trephines have continued to be used by surgeons to the present day for therapeutic purposes on the skull
5/ 1903:
-first attempt to obtain a bone marrow sample by surgical trephine for diagnostics by Pianese (Italy)
-punctured the top part of the epiphysis of a femur
-described a case of anaemia because of bone marrow infiltration by Leishmania as ‘Leishmania Infantum’
6/ 1922:
-Morris and Falconer introduced a method for tibial marrow biopsy using a drill like instrument that produced a marrow specimen very similar to that obtained today
7/ 1920s-30s:
-sternum as main source
-Seyfarth (1922) developed a puncture needle for open biopsy (between 3rd and 4th ribs)
-Anirkin (1927) obtained bone marrow from the sternum using a lumbar puncture needle, used also for the recognition of typhus and tuberculosis
8/ 1936
-Tocantins & O’Neill discovered in rabbits, only 2ml would be obtained at distal end by injecting 5ml of saline into proximal end of the medulla rcavity of a long bone
>>conducted to the idea of an intramedullary infusion
>>previous🧵on BMT
9/ Needles, 1935:
-developed by Klima and Rosegger with guards
-Leitner further modified the needle with the guard running on a thread
10/ What about the hip?
-iliac crest considered as possible puncture site when first deaths were reported in 1943 and 1944 after
sternal aspirations
👉the sternum was completely pierced and the right heart penetrated
👉 sternal puncture be made by light taps with a small hammer
11/ How about the hip?
-not until 1950
-no suitable needles were not available
-Bierman (1952) suggested using posterior iliac crest
-Sacker-Nordin trephine (1954) first provided safe and sufficient material for accurate diagnosis from iliac crest
12/ 1958:
-~5% failure rate in carrying out aspiration biopsies
👉 McFarland & Dameshek described a technique using the Vim-Silverman biopsy needle (published by Silverman 1938)
👉in left lateral position from the right iliac crest, local anaesthetic, without skin incision
13/ 1964:
-Ellis & Westerman reported on ~1500 cases using a modification of the Vim-Silverman needle
👉finger grips, assembly stylet, obturator, larger and sturdier
-commonly used trephine needle in the 1960s/1970s was the Gardner's trephine needle👇
14/ 1971:
-Jamshidi patented his needle
👉inside diameter of the distal part tapered radially towards the cutting edges
👉stylet projects beyond tip protecting the cutting edge and providing easy
enter
👉used during several decades for BM aspiration
15/ Modernity:
-electric drilling biopsies were proposed from the anterior iliac crest
-1988, patent application for an electric biopsy needle by Parapia (with a replaceable needle)👉abandoned -1982, Islam described improvement with lateral holes in distal part of needle👇
16/ Actuality:
-Muschler & Hernigou developed several methods to obtain the highest concentrate BM aspirate possible. 👉highlighted problem of number of cells with more volume vs diluted blood
👉recommend to limit aspiration volumes to 4ml
from each
17/ Maybe there is an easier and less painful method of carrying out BM biopsy (better needles?). Furthermore, liquid biopsies will possibly challenge the necessitiy of the procedure. Till then, it will be one of the first procedures #hematology trainees need to learn.
Rule 1: Lead by example
As a mentor, your actions speak louder than words. Demonstrate the ethics, dedication, and passion you wish to instill in your mentees.
Practice what you preach🙏
Rule 2: Listen actively
Effective mentoring starts with listening. Understand your mentee's needs, fears, and aspirations. This builds trust and opens up more honest communication.
Short intro to sickle cell disease (SCD):
-group of inherited red blood cell disorders
-affects ~ 1 in 500 African American and 1 in 36,000 Hispanic American children
-results in anemia
-main clinical feature is acute painful crisis
👉 often requires hospitalization
2/15
Acute pain:
-one of the most common types of vaso-occlusive events in SCD
BUT
-not all patients are in true crisis
BUT
-pain shouldnt be allowed to progress to crisis
AND
-most patients grow with pain, so ask them how severe it is❗️
-do not to delay analgesia
3/15
Intro:
-rare but underestimated bleeding disorder
-lab and clinic similar to inherited form
-usually occurs more frequently in adults with no history of bleeding
-renewed interest
👉association with 🫀disorders (eg aortic stenosis), cancer, autoimmune disease...
2/14
History I - (inherited) VWS:
-1924
-5-year-old girl from 🇫🇮 brought to hospital in Helsinki, seen by physician Erik Adolf von Willebrand
-assessed 66 members of her family
-reported in a 1926 a previously undescribed bleeding disorder, called "Hereditary pseudohemophilia"
3/14
😱Gastrointestinal (GI) manifestations in hematology😱
A short visual 🧵with diagnosis
1/19
Intro:
-lympho-/myeloproliferative disorders
-nodal and/or extranodal
-GI tract one of the most common extranodal sites
-diagnosis of GI hematologic malignancy challenging
👉esp in absence of documented nodal/extranodal disease
👉due to higher incidence of other pathologies
2/19
Importance of imaging:
-although tissue biopsy is often required to reach the definitive diagnosis, imaging plays a crucial role in raising suspicion of underlying hematologic malignancy
-imaging also guides biopsies, staging, and evaluating response to treatment
3/19
History part I:
-1928, Maurice Richter reported generalized swelling of lymph nodes, liver + spleen in a patient with chronic lymphocytic leukemia (CLL)
-due to infiltration by rapidly growing cells
👉termed it generalized reticular cell sarcoma
-patient died after 22 days
2/20
History part II:
-1964, Lortholary described case series of 14 patients with CLL developing malignant reticulopath
👉occurrence of diffuse large B cell lymphoma (DLBCL)
👉named it Richter's transformation (RT)
-DLBCL most common
-also Hodgkin lymphoma, T cell lymphoma
3/20
When I started med school, I subscribed to the New England Journal of Medicine. Apart from published trials, case records are the world's treasure for education & help navigate clinical courses & differentials better than any class.
A visual 🧵of selected cases #MedTwitter #MedX
50-year-old man with back pain, fatigue, weight loss, and knee swelling
Final diagnosis: Ankylosing spondylitis
-affects 0.5% of population
-strongly associated with HLA-B27 allele
-90% of patients with ankylosing spondylitis are positive for HLA-B27 nejm.org/doi/full/10.10…
60-year-old man with bone pain and skeletal lesions on imaging
Final diagnosis: epithelioid hemangioendothelioma
-affects <300 patients per year in US, ~1% of all vascular neoplasms nejm.org/doi/full/10.10…