In this study
in addition to reporting the longest persistent infection to date:
505days
They describe a case that they call
‘Occult’ infection
It is a case that gave Negative in its PCR several times
and developed COVID symptoms again after several months
In this case
sequencing of the virus genome showed that infection
was caused by the Alpha variant
which had already been removed from the UK by that date
indicating that the virus had persisted latent in the patient for several months
and the PCRtests did not detect it #LongCOVID
Very often PCR of nasal and pharyngeal secretions
they give False Negatives in #LongCOVID#PACS
The problem is that most assume that a Negative PCR of the nose or pharynx
Indicates that there is no virus in the heart, intestines and other parts of the body
UNDIAGNOSED VIRAL PERSISTENCE
IN 32.5% OF PATIENTS UNDERGOING BARIATRIC SURGERY
All had Negative PCR before Surgery
They were unaware they had a Persistent Infection due to SARS-CoV-2
One part had more than 1 year since infection doi.org/10.1007/s11695…
100% of the PCR tests were False Negatives
If the infection persists
the virus will no longer be found in secretions from the nose & throat
It is located inside the cells
Viruses cause Intracellular Infections
PCR cell/tissue samples required in #LongCOVID researchgate.net/publication/34…
The patients operated on in whom it was performed
the finding of
undiagnosed persistent infection
had on average 274 days from the onset of SARS CoV-2 infection
and surgery
61.5% were vaccinated (>2 doses Pfizer)
No differences were identified between vaccinated and unvaccinated
VIRAL PERSISTENCE
IT IS THE MAIN CAUSE OF MYOCARDITIS IN #LONGCOVID
In 85.7%(12/14) of Endomyocardial Biopsies
persistence of up to 18 months of SARS CoV2 was detected
It was identified in Cardiomyocytes,Endothelium,Macrophages
Also Anticardiac Antibodies onlinelibrary.wiley.com/doi/10.1002/cl…
None of the 14 cases had severe respiratory failure or evidence of cardiac injury during Acute COVID
In all of them Myocarditis only manifested itself after the acute phase of COVID
In #LongCOVID#PACS
This was diagnosed 2 to 18 months later
and confirmed by Endomyocardial Biopsy
In 2of the cases
47year-o. women
Myocarditis symptoms appeared only after vaccination
this means
who were carriers of a latent infection
Authors point out:
This suggests a triggering (resolving) role of the vaccine
when administered after an infection
that can remain asymptomatic
PERSISTENCIA VIRAL
ES PRINCIPAL CAUSA DE MIOCARDITIS EN #LONGCOVID
En el 85,7% (12/14)
de las Biopsias Endomiocárdicas se detectó persistencia de hasta 18 meses del SARS CoV2
Se identificó en Cardiomiocitos, Endotelio, Macrófagos
Además Antic.Anticardiacos onlinelibrary.wiley.com/doi/10.1002/cl…
Ninguno de los 14casos tubo insuficiencia respiratoria grave ni evidencia de lesión cardíaca durante el COVID Agudo
En todos, la Miocarditis recién se manifestó después de la fase aguda de COVID
Esta fue diagnosticada 2 a 18meses después
y confirmada por la Biopsia Endomiocárdica
En 2de los casos
mujeres de 47años
los síntomas de Miocarditis aparecieron solo después de la vacunación
es decir
eran portadoras de una infección latente
Autores señalan:
Esto sugiere un papel desencadenante de la vacuna
cuando se administra después de una infección asintomática
PAXLOVID versus TRUVADA
FOR CHRONIC COVID #LONGCOVID#PACS
For costs and side effects
and as months of treatment are required
Win Truvada
containing
Emtricitabine FTC+
Tenofovir Disoproxil FumarateTDF
One could start with Paxlovid and continue with Truvada
I. INTENSIVE PHASE AGAINST VIRAL LOAD
It includes:
1.FTC/TDF (Truvada). The alternative is to start Paxlovid for 10-25 days and then continue with FTC/TDF 2. IVM or Liposomal Artemisinin or Artesunate 3. ECGC or Nitazoxanide or Ozone 10pass
The objective of the INTENSIVE PHASE in CHRONIC COVID #LONGCOVID
is to minimize the Viral Load
Lasts 1-2months
Then follows the Maintenance Phase
whose objective is to avoid the Relapse/Reactivation of the infection
The number of drugs is reduced
Lasts 3 to 8months
depending
case
It had already been identified that the Biofilm or Dental Plaque harbors SARS CoV-2
To this is added the Tonsils and Adenoids in children
Therefore, it is confirmed that the oral cavity is a potential reservoir for the virus
There are Asymptomatic Carriers
In #LongCOVID
For Viral Persistence,
for having Drug-Resistance
we indicate 3 or more medications or supplements with effects against Viral Load
In addition
any infectious focus at the oral level must be eliminated by the Dentist
and mouthwash is indicated
AUTOPSY IN A CHILDREN WITH MULTISYSTEM INFLAMMATORY SYNDROME (MIS-C)
SHOWS VIRAL PERSISTENCE IN MULTIPLE ORGANS
Authors point out
persistence of SARS-COV-2 is a feature in all autopsies of MIS-C patients reported to date, suggesting a role in pathogenesis doi.org/10.1016/j.prp.…
A symptom of Hypoperfusion,Hypercoagulability and Microclots (HHM) are the
MUSCLE SPASM,
TWICHING or
FASCICULATIONS
That in children, adolescents and adults of low weight,
can be diagnosed as
INVOLUNTARY MOVEMENTS of neurological origin
but the problem is in the blood circulation
It is confirmed that the cause of #LongCOVID is Viral Persistence
Apply at home, free of charge, the HHM Test questionnaire
With the result the Treatment will be established.
There is a correlation between the level of the Viral Load and that of Microclots researchgate.net/publication/36…