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Dr. Gustavo Aguirre-Chang Profile picture
Dr. Gustavo Aguirre-Chang
@Aguirre1Gustavo
Treatment of LongCOVID,Post-Vax,ME/CFS,FM Creator of Test for: Viral Persistence,Microclots https://t.co/6Y0z9pQN13 https://t.co/TXxbrQw8QW
4 subscribers
Aug 25 • 5 tweets • 2 min read
ANTIVIRAL THERAPIES
FOR PERSISTENT COVID/LONG COVID
83% SUCCESS
70 of 84 cases with the aggravating factor of immunosuppression

The types of treatment were grouped into:
Prolonged Antiviral therapy
Combination Antivirals
Mixed therapy: Antiviral +Antibody
onlinelibrary.wiley.com/doi/10.1111/ti…
Image
Aug 13 • 7 tweets • 2 min read
Viral persistence has already been sufficiently demonstrated
It was simple for us to do it since April2020
They should no longer spend on studies that do not provide solutions
There are several Antivirals
These studies are postponed
&DrugResistance advance
Jul 6 • 6 tweets • 2 min read
A LOW LEVEL OF OXYGEN IN THE MUSCLES
(HYPOXIA)
IS THE MOST FREQUENT CAUSE OF
CHRONIC FATIGUE
POST-EXERTIONAL MALAISE:PEM
NON-RESTORATIVE SLEEP
MUSCULOSKELETAL STIFFNESS AND PAIN WHEN WAKING UP

This occurs in
ME/CFS
Fibromyalgia
LongCOVID
Post-Vac Syn
Other researchgate.net/publication/38…
Image
Jun 2 • 5 tweets • 2 min read
Histamine causes greater endothelial damage in COVID
by increasing the number of complement C3/C3b binding sites
on the surface of endothelial cells
This
is one more support for our Antihistamine Protocols
before starting Antivirals

doi.org/10.31857/S0233…

Image
Feb 13 • 4 tweets • 2 min read
This study included Biopsies of endothelial tissue and thrombotic clots
Fig.4 shows SARS CoV2 (light circles)
inside clots adhered to infected endothelial cells

It confirms what we graphed almost 3years ago
and we call them BIOCLOTS
mdpi.com/2075-1729/14/2…

Image It will still take years
for it to be accepted that Microclots
serve as a protective barrier
for viruses and other microorganisms to persist
This occurs in several chronic diseases
They are diseases based on Biofilms & Reservoirs
with persistent infections
Feb 12 • 4 tweets • 2 min read
STUDY BASED ON BIOPSIES SHOWS IN SITU PRESENCE OF SARS COV-2
IN ENDOTHELIAL CELLS AND CLOTS

Findings support our Protocols established since 2020
The main thing is to reduce the VIRAL LOAD
Anticoagulant & Antiplatelet Therapy does not go against the CAUSE
mdpi.com/2075-1729/14/2…
Image If there are Persistent Microclots
so
there is a Persistent Infection
which is the main CAUSE to treat
The patient may spend years taking Anticoagulants/Antiplatelets
while
with a Protocol with 3-6 Antivirals the patient can recover in days or a few months
Oct 18, 2023 • 4 tweets • 2 min read
SUDDEN AND UNEXPLAINED DEATHS
Autopsy Study
Authors point out:
Our observations allow us to conclude that
in all cases the SARS-CoV-2 was the cause of death

Results indicate that they had COVID-19
with persistent or chronic viral infection = Chronic COVID
doi.org/10.3390/diagno…
Image In the Abstract of this Autopsy study it is noted:
Particularly noteworthy
are the described cases of children whose deaths were originally classified as SIDS(Sudden Infant Death Syndrome)
They all had COVID
PCR of Nasopharyngeal swabs gave False Negatives
doi.org/10.3390/diagno…
Image
Oct 9, 2023 • 4 tweets • 1 min read
PERSISTENT INFECTION BY SARS COV2
IS CAUSE OF FORMATION OF ARTERIAL PLAQUES,
ATHEROSCLEROSIS AND MYOCARDIAL INFARCTION
Autopsy study shows a causal relationship between SARS CoV2 infection and the formation of arterial plaques and the risk of heart attacks
researchgate.net/publication/37…
Image
Oct 2, 2023 • 4 tweets • 2 min read
Autopsy study in patients with COVID shows that:
SARS-CoV-2 infects, replicates and persists in Macrophages within the coronary vasculature
Since CARDIAC MACROPHAGES have a half-life of 8.8years
they would act as VIRAL RESERVOIRS in Atherosclerotic plaques
nature.com/articles/s4416…
Image It was identified that viral replication was greater in FOAM CELLS
which are Macrophages that have internalized Low-Density Lipoproteins
Its presence and accumulation is accompanied by injury to the vascular walls
that progressively leads to the formation of atheromatous plaques
May 14, 2023 • 4 tweets • 2 min read
There is a Subgroup of patients with
ME/CFS
Long COVID
Fibromyalgia
Arthritis
Autoimmune diseases
Others
Who present with MITOCHONDRIAL DYSFUNCTION
In them the LACTATE (Lactic Acid) rises at rest
And decreases the extraction of oxygen from the venous blood
researchgate.net/publication/35…
Image LACTATE elevation
is it an effect or
consequence of MITOCHONDRIAL DYSFUNCTION
most often caused by
Hypoperfusion,Hypercoagulability and Microclots: HHM
And the severity of HHM symptoms
are correlated with the presence of
Microorganisms as triggering CAUSES
researchgate.net/publication/35…
Image
Jan 8, 2023 • 10 tweets • 6 min read
VENOUS BLOOD GASES (VBG)
In addition to
LongCOVID
Post Vax
They are useful in
ME/CFS
Fibromyalgia
POTS
Lyme
EBV
Bartonella
Arthritis
Sjögren's
Lupus
Ehlers-Danlos
Restless Legs
Fasciculations
Stiff Person
Adrenal Fatigue
Thyroiditis
Mitochondrial Dysfunct.
researchgate.net/publication/35… Image INVERSE CORRELATION WITH MICROCLOTS
We observed that
the lower the value resulting from the
Venous Oxygen Saturation: SvO2
There is a greater amount of #Microclots
and a greater improvement is obtained when giving treatment with
Antiplatelet
Fibrinolytics
Drugs against Viral Load
Jan 8, 2023 • 4 tweets • 3 min read
In this study
in addition to reporting the longest persistent infection to date:
505days
They describe a case that they call
‘Occult’ infection
It is a case that gave Negative in its PCR several times
and developed COVID symptoms again after several months
In this case
sequencing of the virus genome showed that infection
was caused by the Alpha variant
which had already been removed from the UK by that date
indicating that the virus had persisted latent in the patient for several months
and the PCRtests did not detect it
#LongCOVID
Dec 30, 2022 • 4 tweets • 3 min read
UNDIAGNOSED VIRAL PERSISTENCE
IN 32.5% OF PATIENTS UNDERGOING BARIATRIC SURGERY
All had Negative PCR before Surgery
They were unaware they had a Persistent Infection due to SARS-CoV-2
One part had more than 1 year since infection
doi.org/10.1007/s11695…

Are #UndiagnosedLongCOVID 100% of the PCR tests were False Negatives
If the infection persists
the virus will no longer be found in secretions from the nose & throat
It is located inside the cells
Viruses cause Intracellular Infections
PCR cell/tissue samples required in #LongCOVID
researchgate.net/publication/34…
Dec 27, 2022 • 5 tweets • 3 min read
VIRAL PERSISTENCE
IT IS THE MAIN CAUSE OF MYOCARDITIS IN #LONGCOVID
In 85.7%(12/14) of Endomyocardial Biopsies
persistence of up to 18 months of SARS CoV2 was detected
It was identified in Cardiomyocytes,Endothelium,Macrophages
Also Anticardiac Antibodies
onlinelibrary.wiley.com/doi/10.1002/cl… None of the 14 cases had severe respiratory failure or evidence of cardiac injury during Acute COVID
In all of them Myocarditis only manifested itself after the acute phase of COVID
In #LongCOVID #PACS
This was diagnosed 2 to 18 months later
and confirmed by Endomyocardial Biopsy
Dec 27, 2022 • 4 tweets • 2 min read
PERSISTENCIA VIRAL
ES PRINCIPAL CAUSA DE MIOCARDITIS EN #LONGCOVID
En el 85,7% (12/14)
de las Biopsias Endomiocárdicas se detectó persistencia de hasta 18 meses del SARS CoV2
Se identificó en Cardiomiocitos, Endotelio, Macrófagos
Además Antic.Anticardiacos
onlinelibrary.wiley.com/doi/10.1002/cl… Ninguno de los 14casos tubo insuficiencia respiratoria grave ni evidencia de lesión cardíaca durante el COVID Agudo
En todos, la Miocarditis recién se manifestó después de la fase aguda de COVID
Esta fue diagnosticada 2 a 18meses después
y confirmada por la Biopsia Endomiocárdica
Dec 16, 2022 • 5 tweets • 3 min read
PAXLOVID versus TRUVADA
FOR CHRONIC COVID #LONGCOVID #PACS
For costs and side effects
and as months of treatment are required
Win Truvada
containing
Emtricitabine FTC+
Tenofovir Disoproxil FumarateTDF
One could start with Paxlovid and continue with Truvada
PROTOCOLS FOR CHRONIC COVID #LONGCOVID

I. INTENSIVE PHASE AGAINST VIRAL LOAD
It includes:
1.FTC/TDF (Truvada). The alternative is to start Paxlovid for 10-25 days and then continue with FTC/TDF
2. IVM or Liposomal Artemisinin or Artesunate
3. ECGC or Nitazoxanide or Ozone 10pass
Nov 21, 2022 • 5 tweets • 3 min read
ASYMPTOMATIC OR LATENT PERSISTENT INFECTION IN CHILDREN.

SARS COV-2 WAS DETECTED IN BIOPSIES OF TONSILS OR ADENOIDS
IN 25% OF ASYMPTOMATIC CHILDREN
None had experienced signs or symptoms

Authors point out:
lymphoid tissue may be a Reservoir of SARS-CoV-2
doi.org/10.1016/j.bjor… It had already been identified that the Biofilm or Dental Plaque harbors SARS CoV-2
To this is added the Tonsils and Adenoids in children
Therefore, it is confirmed that the oral cavity is a potential reservoir for the virus
There are Asymptomatic Carriers
Nov 15, 2022 • 4 tweets • 3 min read
AUTOPSY IN A CHILDREN WITH MULTISYSTEM INFLAMMATORY SYNDROME (MIS-C)
SHOWS VIRAL PERSISTENCE IN MULTIPLE ORGANS
Authors point out
persistence of SARS-COV-2 is a feature in all autopsies of MIS-C patients reported to date, suggesting a role in pathogenesis
doi.org/10.1016/j.prp.… A symptom of Hypoperfusion,Hypercoagulability and Microclots (HHM) are the
MUSCLE SPASM,
TWICHING or
FASCICULATIONS
That in children, adolescents and adults of low weight,
can be diagnosed as
INVOLUNTARY MOVEMENTS of neurological origin
but the problem is in the blood circulation
Nov 7, 2022 • 9 tweets • 5 min read
IN HOSPITAL IN LONDON, UK, THEY DEMONSTRATE THAT THE LONG COVID (OR CHRONIC COVID) IS DUE TO VIRAL PERSISTENCE
And by means of sequencing of the complete genome (WGS) they identify mutations that cause Drug-Resistance
Report 4 cases with #LongCOVID treated
doi.org/10.1093/cid/ci… Image Case2 corresponds to a patient with #LongCOVID who spent 411days with viral persistence confirmed by PCR Through WGS:Whole Genome Sequencing it is shown that the virus mutates within the patient's body and Drug-Resistance develops
TheWGS guided Antiviral and Monoclonal Ab therapy
Nov 7, 2022 • 9 tweets • 4 min read
EN HOSPITAL EN LONDRES, UK, DEMUESTRAN QUE EL LONG COVID O COVID PERSISTENTE ES DEBIDA A PERSISTENCIA VIRAL
Y mediante secuenciación del genoma completo (WGS) identifican mutaciones que ocasionan Drogo-Resistencia.
Reportan 4 casos con #LongCOVID tratados
doi.org/10.1093/cid/ci… Image El Caso 2 corresponde a un paciente con #LongCOVID que estuvo 411 días con Persistencia viral confirmada mediante PCR. Mediante la WGS se demuestró que el virus muta dentro del organismo y se desarrolla Drogo-Resistencia.
La WGS guio la terapia con Ac Monoclonales y Antivirales