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Hartblik John. Show your heart. Profile picture
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Jan 21 • 16 tweets • 9 min read
🇨🇳 Chinese paper suggest that >4💉would be detrimental. It is cheered by antivaxxers.

Good for in-depth look at paper.
💉A. Paper
💉B. Publicity
💉C. Data shown
💉D. Data not shown
💉E. Method used
💉F. Human data
💉G. Discussion.
💉H. Conclusion.
💉I. Notes.

1/16
💉A. Paper

🇨🇳 Chinese paper has provocative title:

"Extended SARS-CoV-2 RBD booster vaccination induces humoral and cellular immune tolerance in mice"

Spoiler:
The title promises much more than the article does.

sciencedirect.com/science/articl…

2/16
💉B. Publicity

@chrismartenson tweets this as the definite proof repeated vaccination is dangerous.


Martenson has a commercial model of information conferences and books. This fits with his business model.

3/16
💉C. Data shown

The graphs show that the highest antibody titers after 3 immunization, stable after 4, and decrease after 5 & 6 vaccinations.

Effect shown is not dramatic, titers after 6 vaccinations is still higher than after 2 but would be undesired.

4/16
💉D. Data not shown

Anti-SARS-2 immunity is complex.

Immune responses could protect from disease but the highest immune responses are associated with fatal COVID-19.

So how do less high immune responses translate to protection?

5/16
hartblik.weebly.com/special-immuni…
The proof of the pudding would be in the eating i.e., a virus challenge to show immune protection.

The authors discuss that they "used a rodent animal model instead of primates", but did not think about immune protection. they only looked at markers. #fail

6/16
💉E. Method used

The authors used a protein vaccine as used in 🇨🇳.

🇪🇺🇺🇸 use mostly RNA vaccines (Moderna, Pfizer) or vector vaccine (Janssen, 🇬🇧 AstraZeneca, 🇷🇺 Sputnik).

Different vaccines trigger the immune system in different ways.
hartblik.weebly.com/immuunreacties…

7/16
mRNA vaccines yield better protection from disease than classical vaccines by presenting virus antigens in the natural way and direct stimulation of cellular immunity.


8/16
💉F. Human data

Vaccination studies in humans show that a 4th or 5th vaccination confers more protection than three.
pubmed.ncbi.nlm.nih.gov/36560773/
pubmed.ncbi.nlm.nih.gov/36572602/
pubmed.ncbi.nlm.nih.gov/36635284/
pubmed.ncbi.nlm.nih.gov/36642057/

9/16
💉G. Discussion.
🐁It is uncommon and unscientific to overrule findings in the target studies (humans) with lab experiments.
🔬Authors did not investigate protection from disease.
💉Protein vaccines are different from RNA & DNA vaccines and give different immunity.

10/16
SARS-2 infection does not only cause mortality but also significant morbidity, loss of quality of life and delayed mortality. #LongCovid possibly by persistent infection.
sciencedirect.com/science/articl…

hartblik.weebly.com/diseaseoutnumb…


11/16
💉H. Conclusion.

This paper adds very little for most Western countries.
It might cast doubt on the efficacies of repeated vaccination with classical protein vaccines, like those manufactured in China.

Vaccination protects from disease.

12/16
💉I. Notes.

In theory repeated exposure to antigens could deviate immune responses but this is different after mRNA vaccines than other vaccines.


Infections are likely to be worse ...
13/16
Spike is also present in the virus, and in much higher dose, copying itself when immune responses are inefficient.
The virus also has genes to undermine the immune system.


15/16
So it might be speculated that in future fatal tolerance would occur against SARS-CoV-2 but the immunological mechanisms would point to repeated infection as the most risky factor to cause this.

This is another reason to control the epidemic. hartblik.weebly.com/testtraceisola…
16/16
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More from @johnjljacobs

Hartblik John. Show your heart. Profile picture
Jan 21
Long COVID review.
>= 10% severe acute COVID19
>= 200 symptoms - multiple organ systems
>= 65 million individuals

After the acute disease by SARS-CoV-2, it is not over for a large subgroup.
nature.com/articles/s4157…

1/7
Systemic disease:
Impact on heart, lungs, immune system, pancreas, gastrointestinal tract, neurological system, kidneys, spleen & liver, blood vessels & reproductive organs.

Long covid morbidity goes beyond direct mortality
hartblik.weebly.com/diseaseoutnumb…
2/7
SARS-CoV-2 infection, COVID-19 and long COVID increase the risk of several medical conditions:
🫁🫀⚰️🧠
Pulmonary, cardiac, death, stroke, diabetes, fatigue, neurological, cardiovascular.

3/7
Read 8 tweets
Hartblik John. Show your heart. Profile picture
Jan 19
Paper investigates link between mRNA vaccination and myocarditis death. There were some worries about myocarditis in young men.

Evaluation of the evidence of 35 rare unexpected deaths after vaccination 🇩🇪.

1/6
 link.springer.com/article/10.100… Image
35 unexpected deaths examined.

- 10 were under 40 years. None of these died due to mRNA vaccination (1 had AstraZeneca vaccine).

- The authors link 5 cases (46-75 years) likely/possibly to mRNA vaccination.

2/6 Image
All 5 cases had various levels of
🫀 chronic cardiovascular disease (atherosclerosis ) and
🫁 lung disease (local, COPD and pneumonia)

Risk factors in 48-75 years old for COVID-19.

None would be considered healthy.

3/6 ImageImage
Read 7 tweets
Hartblik John. Show your heart. Profile picture
Jan 2
Nasal spray prevents 78% of SARS-2 infections.

Data sounds very interesting but some remarks.
- Young healthy participants ~ 34 (20s, 30s 40s)
- Many adverse events
- Juggling with numbers
- Many drop outs.
- Control data missing.
- Errors
1/9
 medrxiv.org/content/10.110…
Data errors (3x the same in paper!):
🧮135.544 = 27103 + 110441

It is not a major error but indicative for the data presentation.

2/9
Data juggling. 6662 participants
Inclusion. 3368 treatment + 3294 control
RT-PCR 🧪1596 treatment + 5066 control
Apparently drop-outs from treatment inclusion have become controls ....

3/9
Read 9 tweets
Hartblik John. Show your heart. Profile picture
Jan 1
Persistent infections in gastric and gallbladder tissue after SARS-CoV-2 infection.
- Detection of nucleoprotein (infection only - not in vaccine!)
- Up to 1 year (9-12 months) after infection.
- Especially with young people.
- Observed in 1/3 patients
link.springer.com/content/pdf/10…
1/3
SARS-2 viral persistence has been described before in the gut. ncbi.nlm.nih.gov/pmc/articles/P…
molecularcasestudies.cshlp.org/content/7/2/a0…
medrxiv.org/content/medrxi…

And found to be functionally important for the immune system 6 months after infection. 2/3
pubmed.ncbi.nlm.nih.gov/33461210/
This lead to the hypothesis that #LongCovid was caused by a persistent infection. 3/3
sciencedirect.com/science/articl…
Read 4 tweets
Hartblik John. Show your heart. Profile picture
Dec 25, 2022
💉Why are mRNA vaccines so effective?

After decades of trying to make mRNA stable enough to elicit immune responses they seem to outcompete all other vaccines:

💉>90% protection against severe disease compared to ~60% for other vaccine or previous infection

1/8
💉Even better protection from severe disease after boosting.


What is different about mRNA vaccines that makes them so effective.
A. Virology
B. Immunology

2/8
A. Virology.

Viruses have genes for
🧬Reproduction
🦠Packing themselves
🤒Immune dysregulation
hartblik.weebly.com/ontsnappende-v…

Only the genes for packing the virus are included in mRNA vaccines.

Attenuated vaccines have reduced immune dysregulation, but not zero.

3/8
Read 9 tweets
Hartblik John. Show your heart. Profile picture
Dec 23, 2022
Time for a deep dive into SARS-CoV-2 immunology after vaccination and infection. I’ll try to explain it also for non immunologists.
New observation: Booster mRNA vaccines induce antibody switch to IgG4, what does this mean?
science.org/doi/epdf/10.11…
pubmed.ncbi.nlm.nih.gov/36548397/
1/
It is known that immune responses could either protect against disease or exacerbate disease.
Early non-neutralizing, afucosylated IgG1 antibody responses are associated with COVID-19 severity.
pubmed.ncbi.nlm.nih.gov/35040666/
pubmed.ncbi.nlm.nih.gov/36385627/
2/
Previously it was shown that the afucosylated IgG1 antibodies are only found after the first vaccination.
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
3/
Read 16 tweets

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