Thrilled to share our latest article in @NaturePortfolio Reviews Immunology exploring the role of platelets in #immune mediated inflammatory diseases such as #SLE. Open access link π rdcu.be/c4ijW.
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In autoimmune & inflammatory diseases, platelets get activated in response to circulating autoAbs (directly or through FcGR2A binding), soluble factors such as DAMPs or infectious agents (ie through platelet TLR7). Platelet activation often follows disease activity -> biomarker
Upon activation platelets release pro-inflammatory molecules (ie, IL1b), express glycoproteins that promote the interaction with immune cells (ie P-selectin or CD40L) and release plat-derived extracellular vesicles which enhance the inflam « signal » thorough body & organs.
Activated platelets physically interact with immune cells and drive their inflammatory phenotype. In SLE platelet promote type I IFN production by pDCs and stimulate B cells through the CD40L/CD40 axis.
One interaction of interest in between P-selectin expressed on activated platelets & fucosylated PSGL1 expressed by neutrophils & Tregulatory cells. p-selectin promotes neutrophil activation & NETosis and block Treg cells immunomodulatory properties βΆοΈ immune disease π₯π₯π₯ FLARE
Platelets represent promising #therapeutic potential in Immune-Mediated disease. Strategies that block platelet activation (ie aspirin or P2Y12 inhibitor) or platelet/immune cells interaction (ie, anti CD40L or anti-P-selectin) are currently under investigation ! π π
This review was written with the amazing @boilard_eric @GeorgeTsokos @crichez33 and Patrick Blanco ! We Hope you enjoy it and we would love your feedback !
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