Discover and read the best of Twitter Threads about #immune

Most recents (24)

Perhaps people simply err on the side of caution... knowing that a #vaccine is still an experiment still on trial & irreversable , Worse still ? It is being urgently pressed on people by the most #Corrupt #Gov #Gov cherry picked #Scientists #corrupt big #Pharma !
Does this instill people's #TRUST ?
The #vaccine is it seems to be simply a stop gate ...
A timed barrier ..to stop #covid19 ..
But what else is it throwing up ?
The #Delta variant is now escaping & passing through this stop gate ...
Whilst doing so in our bodies , how many new variants or new mutations will surface ? How many jabs or boosters in total will people need ?
What will this do to our own #immune system ? Make it redundant Or less able to cope with "other conditions" ?
Read 10 tweets
Brand New Data #keto #immune

#keto diet improves adaptive immunity through immunometabolic reprogramming without up regulating innate immunity

Basically: stronger immune system with less inflammation 🔥 embopress.org/doi/epdf/10.15…
2/ #Ketogenic diet could also prove to be a valuable measure in the
threatening situation of the current #COVID-19 pandemic” ya, no kidding... in more ways than one
3/ “These new immunological aspects of KD might contribute to the modern concept of metabolic therapy of cancer (Seyfried et al, 2017, 2020). KD not only targets the Warburg effect, but could also
strengthen anti-tumor immunity (Ferrere et al, 2021).” .@Sam_Apple1
#sugar #cancer
Read 3 tweets
Preprint reports elevated serum inflammatory cytokine profile in #LongCovid subjects. Worth noting that an ongoing immune response towards persistent viral reservoirs of #SARS-CoV-2 and/or antigen could explain the findings: medrxiv.org/content/10.110…
2/ So the findings underscore the need to do studies that obtain tissue (via surgery or biopsy if possible) to search for #SARS-CoV-2/antigen in #LongCovid patients. Similar to what this team did (and found viral RNA/antigen in multiple tissue types!): gut.bmj.com/content/early/…
3/ Studying both the LongCovid immune response AND possible #viral reservoirs is very important for LongCovid patients to get the best treatment. If you assume the #immune response alone is the problem, standard of care could become immunosuppressive drugs
Read 4 tweets
As we learn more about #COVIDvaccine #immune response in people w/ #immunedisorders, remember that not all #immunodeficiencies are created equal. You might see in the news claims about #vaccines not working in the #immunocompromised, but that's not always true. A 🧵
One of the earliest articles showed 15% of #transplant patients were Ab positive after dose 1. This increased to 54% after dose 2, but varied by medications being taken. bit.ly/3x00nyA and bit.ly/3cmfria
In #cancer patients, Ab response varied by type of cancer. Two studies showed 92-95% w/ solid tumors were Ab pos after the 2nd dose. One showed only 60% w/ hematological cancers were positive. bit.ly/34LseXc (both) bit.ly/3chrU6s (solid tumor only)
Read 7 tweets
Ultimate victims of media induced fear & politically correct #posturing will be our #children. "hygiene hypothesis: "when exposure to parasites, bacteria, & #viruses is limited early in life, children face a greater chance of [] allergies, asthma, & other #autoimmune diseases..." Image
Dec 10, 2020, Nature: "'#Children are very much adapted to respond — & very well equipped to respond — to new #viruses,' [] even when they are infected w/ #SARSCoV2, children are most likely to experience #mild or #asymptomatic illness." Image
"These children’s #immune systems see the #virus & mounts this really quick & effective immune response that shuts it down, before it has a chance to replicate to the point that it comes up positive on the swab diagnostic test",

Natural #Immunity is not a conspiracy theory.
Read 12 tweets
In the latest issue! Be sure to explore this exciting research about #SARSCoV2 variants and their #escape from #immune response
bit.ly/3e2QxoP

For all @CellPressNews #coronavirus research and commentary, visit cell.com/2019-nCOV
#COVID19
🔽🔽🔽
Mutations in the #SARSCoV2 spike #protein result in tighter binding to the #ACE2 receptor and allow escape from monoclonal #antibody neutralization. Online now! @UniofOxford
bit.ly/3nzukSI
The 501Y.V2 #variant of #SARSCoV2 exhibits resistance to neutralization from monoclonal #antibodies and sera from convalescent as well as #immunized individuals
bit.ly/3xxMrNe
Read 5 tweets
51/x Quoting/translated,

„And again it is shown that T cells can arise without being infected. It is enough if even parts of viruses are inhaled.
The immune response is different in every person.
Immune escape by "mutants" is therefore not possible.„

51.1/x The article (in German)

Contact with SARS-Cov-2 generates Memory T cells even without infection

[Kontakt mit SARS-Cov-2 erzeugt Speicher-T-Zellen auch ohne Infektion]

tkp.at/2021/03/27/kon…
51.2/x The paper

Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

nature.com/articles/s4146…
Read 50 tweets
1/ A: Celebrate the mild #flu season & take what we have learned this year to inform future behavior. Harmful germs are not going away. 🦠 Illness from bacteria & viruses that make us sick do not “strengthen” the #immune system & contribute to significant complications & death. Image
2/ The lack of infectious illnesses will not #weaken your #immunesystem. Public health measures to combat #COVID19 including social distancing, masks, & extra hand washing greatly reduced the incidence of some bad microbes that cause common infectious illnesses such as the flu.
3/ More than 15,000 US deaths attributed to the #flu were averted this year. Other common viruses, like rhinoviruses, did not decrease as consistently. #Bacteria & #viruses that cause illness will continue to exist. go.nature.com/2OxkiUv
Read 9 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
#Cassandra: #SARS1 bound "Spikes" to Human #ACE2 receptors ONLY. Those are rare in healthy people.

In #SARS2 & #MUTANTS (#COVID19) they now bind ALSO to #Furin receptors, as in #HIV/#AIDS & #Ebola, which makes it 1000 x as #Infectuous:

— RT World News rt.com/news/481837-co…
#Cassandra: January 2020 article:

Uncanny similarity of 4 unique #Inserts in the 2019-nCoV (SARS-CoV-2) spike protein to #HIV1 (AIDS) #Gp120 and #Gag:

->biorxiv.org/content/10.110…
#Cassandra: Article March 2020.

#SARS_CoV_2 (COVID19) is NOT Natural !

#Czech molecular biologist, Dr. Soňa Peková explains in layman terms that #COVID19 virus originates from a lab, and the Americans try to refute it (Updated):

dimsumdaily.hk/czech-molecula… via @dimsum Daily
Read 10 tweets
Once Upon a Time: an RNA vaccine! How does the #vaccine work, and what happens if the #coronavirus tries to attack a vaccinated person? @helsinkiuni @HelsinkiOne @LifeSciHelsinki PDF: bit.ly/coronavacc #COVID19 #COVID19Vaccine #SARSCoV2 ImageImage
For a bit more #immunology: Once Upon a Time - #immunity! How does our marvellous adaptive #immune system work? @helsinkiuni @HelsinkiOne @LifeSciHelsinki PDF: bit.ly/comic_immunity ImageImage
Small (but important) correction to Immunity Episode One! The T cells in this story actually are Tim, Tanya and Tucker (not Tobias and Tiffany). They all look so similar that I always get confused! Image
Read 4 tweets
The United States Court of Appeals for the #DCCircuit



#RadiationSickness

@FCC
@US_FDA
#CourtHearings
Jump to around 2 hours in if you replay it.
Read 16 tweets
Our first paper authors.elsevier.com/a/1cRqD6tu0Cbo… is now out @CellStemCell! With @ionispharma & the Jamieson Lab @UCSanDiegoDRM, we found that selective #antisense oligonucleotides inhibiting #IRF4 reduce disease burden & #multiplemyeloma #regeneration in #cancer models. @CellPressNews 1/ Image
IRF4 (interferon regulatory factor 4) is a key plasma cell transcription factor that is known to play a critical role in #myeloma progression. It's been shown to activate networks of #cellcycle and cancer regulators, including the notorious #cancer and #stemcell gene, #MYC. 2/ Image
In this new work, the talented @PhoebeMondala & @AshniVora first dug deeper into the IRF4 networks activated in high-risk forms of #myeloma, including #plasmacellleukemia. IRF4 target genes (SLAMF7, BCMA) were widely induced, especially among genes regulating the #cellcycle. 3/ Image
Read 15 tweets
1/x T-cell tests vs #antibodytests

Diagnosis and Tracking of Past SARSCoV2 Infection in Large Study of Vo’ #Italy Thru T-Cell Receptor Sequencing

Quote
“..70 [of 2,200] with PCR-confirmed SARSCoV2 infection [had] blood samples taken 60 days after PCR..”

depts.washington.edu/pandemicallian…
2/x Con’t quoting,

“97% of [70] had a positive T-cell test result ... HIGHER than the antibody serology assay (77%).

T-cell response was associated with disease severity ..
significantly higher response among .. symptomatic or hospitalized compared to .. asymptomatic.”
3/3 The science paper:

Diagnosis and Tracking of Past SARS-CoV-2 Infection in a Large Study of Vo’ Italy Through T-Cell Receptor Sequencing.

medrxiv.org/content/10.110…
Read 82 tweets
Daily Bookmarks to GAVNet 12/17/2020 greeneracresvaluenetwork.wordpress.com/2020/12/17/dai…
Are the elites worse than you think? - Marginal REVOLUTION

marginalrevolution.com/marginalrevolu…

#elites #DecisionMaking
Congress to Pass $17 Billion Bailout of Airline Shareholders & Bondholders, to Top Off Prior Bailout. Industry Applauds, Airline Stocks Jump | Wolf Street

wolfstreet.com/2020/12/15/con…

#bailout
Read 8 tweets
1/ This excellent study by @aaronmring/@VirusesImmunity and team found that COVID-19 patients exhibit dramatic increases in the production of antibodies against thousands of human extracellular and secreted proteins (the exoproteome) compared to controls 👇
2/ The million dollar question is: what molecular mechanisms underly this antibody/#autoantibody production? It is worth interpreting the findings via the lens of human #microbiome/#virome activity + the activity of persistent pathogens (such as EBV) harbored by study subjects.
3/ Every study subject harbored extensive microbiome/virome communities comprised of trillions of organisms during #COVID-19 infection…with such ecosystems now understood to persist beyond just the gut but also in other body sites (#lung, liver etc).
Read 15 tweets
Important paper 👉 A team in Tokyo took RNA-seq data from the Genomic-#Tissue Expression Project: a public resource created to study tissue-specific gene expression/regulation from 54 tissue types collected from 1000+ healthy individuals at autopsy: bmcbiol.biomedcentral.com/articles/10.11…
2/ They successfully identified 39 viral species in at least one tissue (tissue types included #brain, pituitary, esophagus, thyroid, #heart, breast, lung, kidney, adrenal gland, prostate, #nerve, adipose tissue, blood vessel, ovary, uterus etc)
3/ Viruses identified in the various tissue samples included EBV, HSV-1, Varicella, CMV, HHV6-A/B, HHV-7, HCV, HPV, adeno-associated virus...and 16 RNA #viruses including Respiratory syncytial virus (RSV), Parainfluenza Virus 3..
Read 12 tweets
Did you miss the talk "Panorama of #lupus in 2020?" I did yesterday for @LupusEurope?

No worries, I'm starting a #tweeter #SLE #thread so that you can pick up the slides you're interested in 👍

Check below for the SLIDES ⬇️
Slide #1
Current classification of #Lupus
Slide #2
What is #lupus #SLE
#Lupusawareness
Read 18 tweets
What are the implications of excess global financial market volatility on economic growth? Are there threshold effects in the relationship between growth & excess global volatility for individual countries? How should we model the nonlinear effects in a multi-country setting? 1/n
We answer these questions in recent work with Alexander Chudik @DallasFed, M Hashem Pesaran @USCDornsife @TrinCollCam, @mraissi80 @IMFNews & @arebucci1 @JHUCarey @cepr_org @nberpubs: ideas.repec.org/p/cam/camdae/2… #TGVAR 2/n
The #Covid19 #pandemic has been a shock like no other, initiating simultaneous demand and supply disruptions. In addition, it led to a sharp tightening in global #financial market conditions during the first quarter of 2020. 3/n Image
Read 23 tweets
Daily Bookmarks to GAVNet 09/14/2020 greeneracresvaluenetwork.wordpress.com/2020/09/14/dai…
How CRISPR is tackling the troubling immune response that's plagued gene therapy until now

thenextweb.com/syndication/20…

#CRISPR #immune #therapy #gene #response
Less likely than being struck by lightning? Think I’ll stay indoors

unherd.com/thepost/less-l…

#AvailabilityBias #COVID19 #UnitedKingdom
Read 8 tweets
Daily Bookmarks to GAVNet 09/04/2020 greeneracresvaluenetwork.wordpress.com/2020/09/04/dai…
Study blows 'greenhouse theory out of the water'

wnd.com/2017/07/study-…

#ClimateChange #greenhouse
Read 14 tweets
After 6 months of #lockdown and #lab shutdown I spent a full day 9 am-8 pm in lab doing experiments! New #grad students in #lifesciences: There is always light 💡 and #fluorescent images at the end of the tunnel! Filing a #patent on my #invention from #phd work soon @OrganOnAChip
This is an Organ on a Chip platform that enables mimicking #tissues and #organs in a high throughput manner! The main focus will be towards developing #mucosal organs with tissue resident #immune cells and lining #epithelial cells for #testing #COVID19 treatments #covidvaccines
I recently gave a talk at #oooc2020 organized by @GVNlab at @Columbia. In the talk I demonstrated the #ease of fabrication, #functionality, and #modularity of this platform.
We’re open to #collaborate with interested #researchers! Interested to learn more:
Read 11 tweets
Daily Bookmarks to GAVNet 08/07/2020 greeneracresvaluenetwork.wordpress.com/2020/08/07/dai…
The Pandemic's Biggest Mystery Is Our Own Immune System - The Atlantic

theatlantic.com/health/archive…

#pandemic #system #immune #mystery
In northern China, scientists have found what may be the 2 billion-year-old birthmarks of Earth's first supercontinent

sciencex.com/news/2020-08-n…

#china #geological #earth
Read 10 tweets

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