Thread by @realDaveFeldman

Yes, read it when it came out.

For those who've followed my work and know where I'm coming from, WHY would I fully expect LDL-TG (triglyceride content per LDL particle) to closely associate with atherosclerosis?

(By now this should be a very easy question.)

https://twitter.com/scstse/status/1619872817813811201

2/ Let's start with causal directionality.

Which of the following are possible?

1) High LDL-TG is causing higher atherosclerosis

2) One or more things are causing both higher LDL-TG and higher atherosclerosis

Answer is: Both are possible.

Now that said, it is way more common for people to only consider (1) and not (2)

I regularly do my best to get folks to consider (2) as well -- and have been doing so for several years now.

Example: this one w/ @jerryteixeira and @LowCarbEyeDoc

I'm not bringing these to light for a humble brag of some kind, just pointing to why these associations make a lot of sense under LEM.

We should be asking "why" ⬆️TG on LDL associates with ASCVD...

https://twitter.com/realDaveFeldman/status/1401204436249190400

If it's due to dysfunction in lipid metabolism such that CETP is going up and lipoprotein lipase activity is going down, then it makes a great deal of sense this will change the composition of lipoproteins downstream -- particularly LDL.

See Figure 3b of our #LEM paper

Also, link to our #LEM paper in full: mdpi.com/2218-1989/12/5…

And if I can add -- I think LMHRs will show TG/CE ratios in the aggregate at levels never seen before. We'll know this soon with the coming #LMHRstudy data.