1/ It seems the new trend is talking about food "satiety" scores
Superficially the approach makes sense… prioritize foods that’ll keep your full and thus you will lose weight. Sensible, right?
Maybe, or maybe not...
2/ 1st, satiety is an abstract concept
The best one can do is try to operationalize by creating scores based on other variables
@DietDoctor does this
[combines] "factors that make a food more satisfying: protein percentage, energy density, fiber content, and a hedonic factor."
3/ However, such composite scoring systems have the problems. We know this from examples like the NPS that ranked lucky charms healthier than eggs!
Everyone was upset, right? Well, satiety scoring system presents a double standard
4/ Satiety per calorie scoring system creates a perverted hierarchy of food using what is at it's core a calorie-centric model, Eg macadamia nuts score worse than fried chicken or a club sandwich....
5/ Additionally, even if one had the perfect algorithm…
(presently seems pretty opaque @AdrianSotoMota)
The data upon which it is based is flimsy
For example, “hedonic factor” just means how much someone likes the food, which creates a tautology within the concept itself!
6/ If you (personally) like food "X" then your personal hedonic score for "X" will be higher than someone who doesn't like "X"
How then can one integrate a hedonic factor in to a generalizable satiety score? Not to mention, how do you weight the factors against each other?
7/ Building on this, the approach is a calorie centric model by another name. IMO, it reinforces a CICO approach to obesity management; with emphasis on calorie in rather than on the complex metabolic effects of foods, as per CIM; and...
8/ There isn’t any factor in the model a present for nutrient density (QED fried chicken vs. macadamia) or area for integrating the effects of macronutrient composition on energy expenditure, as per CIM and the RCT data...
9/ In summary, I think it IS smart to know yourself, and what foods satisfy YOU, and which are YOUR personal “forbidden fruits” but I can’t say I see much genuine value add to a satiety scoring system
10/ As a final aside, if someone disagrees strongly, I suggest publishing open access code and clinical data on a satiety scoring system. I'd be more than happy myself to help get any manuscript out for an independent peer-review
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2/4) Using 🐁 model researchers show light impairs brown fat thermogenesis and glucose tolerance directly via axis composed of:
I) photo-sensitive retinal ganglion cells
II) supraoptic nucleus
III) paraventricular nucleus
IV) nucleus solitary tract
V) rostal raphe nucleus
3/4) They then demonstrate these data are directly relevant to humans! Notably, it's exposure to blue light that activates the axis to impair glucose tolerance
This makes sense since photo-sensitive retinal ganglion cells are sensitive to blue light more than red light.
3/6) Additionally, ketones are known to have an appetite reducing effect via their signaling properties in the brain. This may be one reason some people report weight loss success with the aid of exogenous ketone supplements
1) As you may have heard, the FDA has approved the weight loss drug semaglutide (a GLP-1 agonist) for kids 12 and older with #obesity
Good? Bad? I wanted to do a thread 🧵on the STEP TEENS data with some thoughts...
PLZ READ IN FULL
2) Semaglutide Treatment Effect in People (STEP) with obesity TEENS trial was a double-blind RCT that lasted 68 weeks & included kids 12-18 years. 180 completed the trial
3) The data show 16.1% weight loss in the semaglutide plus lifestyle intervention group, as compared to no BMI change in the placebo plus lifestyle group over 68 weeks. (nb: after semaglutide discontinuation for 7 weeks, weight began to rebound as expected)
& of course, for those who have the time, I highly recommend reading the full paper, here: doi.org/10.1016/j.ajcn…
But for those who prefer video or TW thread... HERE WE GO...
3/18) What the researchers did in this paper is perform a secondary analysis of pre-existing data from a 12-month RCT: the DIETFITS trial in which 609 adults aged 18-50 without diabetes were randomized to either a 12 m Low-carb diet (LCD) or low-fa diet (LFD).
But instead, I CHALLENGE YOU 🫵 to put aside emotions & watch 1 of these videos
11 m:
45 m:
1/ NOW for 🧵 on 5 MYTHS about eating Bugs!
A DISCLAIMER
I am NOT trying to take your meat
I am NOT saying meat is unhealthy
I am NOT trying to force you to eat bugs
I am NOT trying to force you to eat bugs
I am NOT trying to force you to eat bugs
I AM asking you to set aside emotion and have an open mind
Begin...
2/ MYTH #1) People only eat bugs if they need to
Entomophagy is a cultural practice
The "eww" factor is entirely psychological
Many cultures eat bugs as delicacies, EVEN when meat is also part of the diet
Norms change. Take🦞a large bug that used to be considered slave food