Nick Norwitz Profile picture
Jan 30 10 tweets 4 min read
#Satiety Science, thread! 🧵

1/ It seems the new trend is talking about food "satiety" scores

Superficially the approach makes sense… prioritize foods that’ll keep your full and thus you will lose weight. Sensible, right?

Maybe, or maybe not...
2/ 1st, satiety is an abstract concept

The best one can do is try to operationalize by creating scores based on other variables

@DietDoctor does this
[combines] "factors that make a food more satisfying: protein percentage, energy density, fiber content, and a hedonic factor." Image
3/ However, such composite scoring systems have the problems. We know this from examples like the NPS that ranked lucky charms healthier than eggs!

Everyone was upset, right? Well, satiety scoring system presents a double standard Image
4/ Satiety per calorie scoring system creates a perverted hierarchy of food using what is at it's core a calorie-centric model, Eg macadamia nuts score worse than fried chicken or a club sandwich.... ImageImage
5/ Additionally, even if one had the perfect algorithm…
(presently seems pretty opaque @AdrianSotoMota)

The data upon which it is based is flimsy

For example, “hedonic factor” just means how much someone likes the food, which creates a tautology within the concept itself! Image
6/ If you (personally) like food "X" then your personal hedonic score for "X" will be higher than someone who doesn't like "X"

How then can one integrate a hedonic factor in to a generalizable satiety score? Not to mention, how do you weight the factors against each other?
7/ Building on this, the approach is a calorie centric model by another name. IMO, it reinforces a CICO approach to obesity management; with emphasis on calorie in rather than on the complex metabolic effects of foods, as per CIM; and...
8/ There isn’t any factor in the model a present for nutrient density (QED fried chicken vs. macadamia) or area for integrating the effects of macronutrient composition on energy expenditure, as per CIM and the RCT data...
9/ In summary, I think it IS smart to know yourself, and what foods satisfy YOU, and which are YOUR personal “forbidden fruits” but I can’t say I see much genuine value add to a satiety scoring system
10/ As a final aside, if someone disagrees strongly, I suggest publishing open access code and clinical data on a satiety scoring system. I'd be more than happy myself to help get any manuscript out for an independent peer-review

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Nick Norwitz

Nick Norwitz Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @nicknorwitz

Jan 28
1/4)🚨 WOW! SOO COOL!

NEW DATA in @CellCellPress show that light can directly alter human glucose tolerance via a light-eye-brain-brown fat axis 🧠

5 min video:
ht/ @hubermanlab Image
2/4) Using 🐁 model researchers show light impairs brown fat thermogenesis and glucose tolerance directly via axis composed of:
I) photo-sensitive retinal ganglion cells
II) supraoptic nucleus
III) paraventricular nucleus
IV) nucleus solitary tract
V) rostal raphe nucleus ImageImage
3/4) They then demonstrate these data are directly relevant to humans! Notably, it's exposure to blue light that activates the axis to impair glucose tolerance

This makes sense since photo-sensitive retinal ganglion cells are sensitive to blue light more than red light. ImageImage
Read 5 tweets
Jan 22
1/6) This TW screenshot has received a lot of traction

Personally, I read it as "ketosis itself doesn't enhance weight loss, as compared to carbohydrate restriction without ketones >0.5mM."

Nevertheless, I think this is an interesting topic. So... THREAD!
@DrEenfeldt
2/6) First, consider weight loss. RCT data show that carbohydrate restriction can increase total energy expenditure in a dose-response manner

Thus, ketogenic - be virtue of being very low carb - may have an edge in terms of energy expenditure

pubmed.ncbi.nlm.nih.gov/30429127/
3/6) Additionally, ketones are known to have an appetite reducing effect via their signaling properties in the brain. This may be one reason some people report weight loss success with the aid of exogenous ketone supplements

All that said...
Read 6 tweets
Jan 14
Weight loss drugs for kids!

1) As you may have heard, the FDA has approved the weight loss drug semaglutide (a GLP-1 agonist) for kids 12 and older with #obesity

Good? Bad? I wanted to do a thread 🧵on the STEP TEENS data with some thoughts...

PLZ READ IN FULL
2) Semaglutide Treatment Effect in People (STEP) with obesity TEENS trial was a double-blind RCT that lasted 68 weeks & included kids 12-18 years. 180 completed the trial

Baseline means:
-Mean age was 15.4 years
-BMI = 37
-Weight = 237lbs
nejm.org/doi/full/10.10…
3) The data show 16.1% weight loss in the semaglutide plus lifestyle intervention group, as compared to no BMI change in the placebo plus lifestyle group over 68 weeks. (nb: after semaglutide discontinuation for 7 weeks, weight began to rebound as expected)
Read 15 tweets
Jan 6
1/18) 🚨NEW PAPER in @AJCN provides evidence supporting #CIM of #obesity

👉 Glycemic Load >>> Calorie Counting for weight loss

👉 Biomarkers of Low carb diet predict weight

👉Insulin hyper-secreters especially benefit fromlow-carb

Video 👉👉
🧵... Image
2/18) First, and foremost, a big congrats to @AdrianSotoMota and @davidludwigmd for an excellent work!

& of course, for those who have the time, I highly recommend reading the full paper, here: doi.org/10.1016/j.ajcn…

But for those who prefer video or TW thread... HERE WE GO...
3/18) What the researchers did in this paper is perform a secondary analysis of pre-existing data from a 12-month RCT: the DIETFITS trial in which 609 adults aged 18-50 without diabetes were randomized to either a 12 m Low-carb diet (LCD) or low-fa diet (LFD).
Read 18 tweets
Jan 1
New Year #Egg 🥚Hacks

(1/3) Cream Crispy

Pour heavy cream in bottom of a non-stick pan & sprinkle w/ salt

Add eggs

Watch as cream boils & caramelizes the edges and converts to butter 🧈

Result = Caramelized whites with Creamy runny yolks and rich brown butter aroma!
(2/3) Cream Brown-Butter Scrambled

Heat just 1 Tbsp cream skillet & let it cook until well caramelized

Then add a 2-3 Tbsp of fresh cold cream to rapidly reduce the temperature of the pan, stirring to re-emulsify fat

Streamed in beaten eggs
P.S. Cream-scrambled eggs dry out on reheating like normal scrambled eggs

Just microwaved or gently heated on the stovetop with a splash of milk & as good as freshly cooked!
Read 4 tweets
Dec 31, 2022
My YouTube w @KenDBerryMD on #Entomophagy has gotten 🔥 responses!

Should I back off? Probs

But instead, I CHALLENGE YOU 🫵 to put aside emotions & watch 1 of these videos

11 m:
45 m:

1/ NOW for 🧵 on 5 MYTHS about eating Bugs!
A DISCLAIMER

I am NOT trying to take your meat
I am NOT saying meat is unhealthy
I am NOT trying to force you to eat bugs
I am NOT trying to force you to eat bugs
I am NOT trying to force you to eat bugs

I AM asking you to set aside emotion and have an open mind

Begin...
2/ MYTH #1) People only eat bugs if they need to

Entomophagy is a cultural practice

The "eww" factor is entirely psychological

Many cultures eat bugs as delicacies, EVEN when meat is also part of the diet

Norms change. Take🦞a large bug that used to be considered slave food
Read 12 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(