Nick Norwitz Profile picture
Feb 3 4 tweets 2 min read
1/4) “Satiety score” score suggest macadamia nuts are more likely to promote weight gain and prevent weight loss than cheesecake?! (higher = more satiety) 🧐

Macadamia = 17
Cheesecake = 19

Battered fried shrimp = 35
Apple juice = 32
Fried zucchini fritters 27

#satiety
2/4) First, lest address the science. Do macadamia nuts cause weight gain?

In a 4 week interventional trial in which people were instructed to eat 40-90 grams of macadamia there was actually a net weight loss.

Try getting those results with cheesecake…
3/4)

Over past few days, I’ve gotten dozens of messages expressing disappointment in the new satiety scoring system

It’s a reasonable concept at best, but definitely not ready to be available as a public tool if it’s promoting cheesecake and apple juice over raw nuts.
4/4) Finally, I’m calling on members of the DD scientific advisory board @KenDBerryMD @DoctorTro to chime in with their opinions on satiety scoring algo because I can’t imagine the majority are in support of this tool

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More from @nicknorwitz

Feb 4
1/ How to poo 💩! Was listening to the new @hubermanlab with @DrGottfried this AM (at 3:37) on hormones and #constipation & was inspired to do a little thread on my top #6 tips for dealing with constipation ... hopefully this thread helps at least 1 silent sufferer
2/ This is a topic I'm interested in is bc as someone with a hx of proctitis + cecal patch (form of ulcerative colitis strongly linked to constipation), it's something I've struggled w/ at times. It's not fun & a far more prevalent problem than people realize 4 obvious reasons
3/ Let's start the list.

#1 tip has nothing to do with diet, but technique!

In normal seated position with knees at 90o, your puborectalis muscle strangles your rectum. If you squat with the assistance of a squatty potty (or 'toilet yoga') you receive this strangle-hold ImageImage
Read 10 tweets
Jan 30
#Satiety Science, thread! 🧵

1/ It seems the new trend is talking about food "satiety" scores

Superficially the approach makes sense… prioritize foods that’ll keep your full and thus you will lose weight. Sensible, right?

Maybe, or maybe not...
2/ 1st, satiety is an abstract concept

The best one can do is try to operationalize by creating scores based on other variables

@DietDoctor does this
[combines] "factors that make a food more satisfying: protein percentage, energy density, fiber content, and a hedonic factor." Image
3/ However, such composite scoring systems have the problems. We know this from examples like the NPS that ranked lucky charms healthier than eggs!

Everyone was upset, right? Well, satiety scoring system presents a double standard Image
Read 10 tweets
Jan 28
1/4)🚨 WOW! SOO COOL!

NEW DATA in @CellCellPress show that light can directly alter human glucose tolerance via a light-eye-brain-brown fat axis 🧠

5 min video:
ht/ @hubermanlab Image
2/4) Using 🐁 model researchers show light impairs brown fat thermogenesis and glucose tolerance directly via axis composed of:
I) photo-sensitive retinal ganglion cells
II) supraoptic nucleus
III) paraventricular nucleus
IV) nucleus solitary tract
V) rostal raphe nucleus ImageImage
3/4) They then demonstrate these data are directly relevant to humans! Notably, it's exposure to blue light that activates the axis to impair glucose tolerance

This makes sense since photo-sensitive retinal ganglion cells are sensitive to blue light more than red light. ImageImage
Read 5 tweets
Jan 22
1/6) This TW screenshot has received a lot of traction

Personally, I read it as "ketosis itself doesn't enhance weight loss, as compared to carbohydrate restriction without ketones >0.5mM."

Nevertheless, I think this is an interesting topic. So... THREAD!
@DrEenfeldt
2/6) First, consider weight loss. RCT data show that carbohydrate restriction can increase total energy expenditure in a dose-response manner

Thus, ketogenic - be virtue of being very low carb - may have an edge in terms of energy expenditure

pubmed.ncbi.nlm.nih.gov/30429127/
3/6) Additionally, ketones are known to have an appetite reducing effect via their signaling properties in the brain. This may be one reason some people report weight loss success with the aid of exogenous ketone supplements

All that said...
Read 6 tweets
Jan 14
Weight loss drugs for kids!

1) As you may have heard, the FDA has approved the weight loss drug semaglutide (a GLP-1 agonist) for kids 12 and older with #obesity

Good? Bad? I wanted to do a thread 🧵on the STEP TEENS data with some thoughts...

PLZ READ IN FULL
2) Semaglutide Treatment Effect in People (STEP) with obesity TEENS trial was a double-blind RCT that lasted 68 weeks & included kids 12-18 years. 180 completed the trial

Baseline means:
-Mean age was 15.4 years
-BMI = 37
-Weight = 237lbs
nejm.org/doi/full/10.10…
3) The data show 16.1% weight loss in the semaglutide plus lifestyle intervention group, as compared to no BMI change in the placebo plus lifestyle group over 68 weeks. (nb: after semaglutide discontinuation for 7 weeks, weight began to rebound as expected)
Read 15 tweets
Jan 6
1/18) 🚨NEW PAPER in @AJCN provides evidence supporting #CIM of #obesity

👉 Glycemic Load >>> Calorie Counting for weight loss

👉 Biomarkers of Low carb diet predict weight

👉Insulin hyper-secreters especially benefit fromlow-carb

Video 👉👉
🧵... Image
2/18) First, and foremost, a big congrats to @AdrianSotoMota and @davidludwigmd for an excellent work!

& of course, for those who have the time, I highly recommend reading the full paper, here: doi.org/10.1016/j.ajcn…

But for those who prefer video or TW thread... HERE WE GO...
3/18) What the researchers did in this paper is perform a secondary analysis of pre-existing data from a 12-month RCT: the DIETFITS trial in which 609 adults aged 18-50 without diabetes were randomized to either a 12 m Low-carb diet (LCD) or low-fa diet (LFD).
Read 18 tweets

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