1/ How to poo 💩! Was listening to the new @hubermanlab with @DrGottfried this AM (at 3:37) on hormones and #constipation & was inspired to do a little thread on my top #6 tips for dealing with constipation ... hopefully this thread helps at least 1 silent sufferer
2/ This is a topic I'm interested in is bc as someone with a hx of proctitis + cecal patch (form of ulcerative colitis strongly linked to constipation), it's something I've struggled w/ at times. It's not fun & a far more prevalent problem than people realize 4 obvious reasons
3/ Let's start the list.
#1 tip has nothing to do with diet, but technique!
In normal seated position with knees at 90o, your puborectalis muscle strangles your rectum. If you squat with the assistance of a squatty potty (or 'toilet yoga') you receive this strangle-hold
4/ Tip #2 I'd take with a grain of salt, but it is the standard 'have you tried fiber.' I think fiber is certainly oversold (and can make the issue worse for some), but for others it can help so it's worth a try initially. I'd target insoluble fiber > soluble fiber. Lower bloat
5/ Tip #3 is oral osmotics. Taking 400-600 grams magnesium citrate at bedtime may be sufficient to soften the stool. Importantly, osmotics don't create dependence like stimulant laxatives (Senna, biscodyl, etc.)
6/ Tip #4 is stimulating your system in the morning with coffee (caffeinated works better than decaf, although it's not clear why) and/or hot water or tea. Adding a dash of acid in the form of lemon juice or ACV can help.
7/ Tip #5 is to turn to more immediate rectal osmotics , including glycerin suppositories & thin-tipped water enemas (water warm, not too hot). These can be great bc they create a strong stimulus to go in as little at 20 min (glycerin) & immediate (for water enema). Convenient
8/ Tip #6 is trying to do a microbiome reset. This can be ambitious and comes in many forms. For example, one protocol I did was several months of carnivore to 'reset' & then used Seed probiotic (best on the market IMO) and then titrated up fermented foods (kimchi, natto, kefir)
9/ Interestingly, while it wasn't a cure all, that protocol has allowed me to consume A2 dairy (including higher lactose kefirs) without bloating on constipation. Here's the link to seed: seed.com
10/ I'll cut this thread there and just mention it's certainly not comprehensive. Exercise, good sleep, certain forms of yoga, and hormonal testing (e.g. for hypothyroid) can all be helpful as well. And, remember, everybody poops!
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1/4) “Satiety score” score suggest macadamia nuts are more likely to promote weight gain and prevent weight loss than cheesecake?! (higher = more satiety) 🧐
Macadamia = 17
Cheesecake = 19
Battered fried shrimp = 35
Apple juice = 32
Fried zucchini fritters 27
2/4) First, lest address the science. Do macadamia nuts cause weight gain?
In a 4 week interventional trial in which people were instructed to eat 40-90 grams of macadamia there was actually a net weight loss.
Try getting those results with cheesecake…
3/4)
Over past few days, I’ve gotten dozens of messages expressing disappointment in the new satiety scoring system
It’s a reasonable concept at best, but definitely not ready to be available as a public tool if it’s promoting cheesecake and apple juice over raw nuts.
2/4) Using 🐁 model researchers show light impairs brown fat thermogenesis and glucose tolerance directly via axis composed of:
I) photo-sensitive retinal ganglion cells
II) supraoptic nucleus
III) paraventricular nucleus
IV) nucleus solitary tract
V) rostal raphe nucleus
3/4) They then demonstrate these data are directly relevant to humans! Notably, it's exposure to blue light that activates the axis to impair glucose tolerance
This makes sense since photo-sensitive retinal ganglion cells are sensitive to blue light more than red light.
3/6) Additionally, ketones are known to have an appetite reducing effect via their signaling properties in the brain. This may be one reason some people report weight loss success with the aid of exogenous ketone supplements
1) As you may have heard, the FDA has approved the weight loss drug semaglutide (a GLP-1 agonist) for kids 12 and older with #obesity
Good? Bad? I wanted to do a thread 🧵on the STEP TEENS data with some thoughts...
PLZ READ IN FULL
2) Semaglutide Treatment Effect in People (STEP) with obesity TEENS trial was a double-blind RCT that lasted 68 weeks & included kids 12-18 years. 180 completed the trial
3) The data show 16.1% weight loss in the semaglutide plus lifestyle intervention group, as compared to no BMI change in the placebo plus lifestyle group over 68 weeks. (nb: after semaglutide discontinuation for 7 weeks, weight began to rebound as expected)
& of course, for those who have the time, I highly recommend reading the full paper, here: doi.org/10.1016/j.ajcn…
But for those who prefer video or TW thread... HERE WE GO...
3/18) What the researchers did in this paper is perform a secondary analysis of pre-existing data from a 12-month RCT: the DIETFITS trial in which 609 adults aged 18-50 without diabetes were randomized to either a 12 m Low-carb diet (LCD) or low-fa diet (LFD).