Fantini 2023 show electrostatic surface potential modulates spike-ganglioside interactions, to control the hemagglutination properties of coronaviruses SARS-CoV/-2, MERS-CoV and the structural dynamics of SARS-CoV-2 evolution. And HIV, influenza, #mpox. 👍 mdpi.com/1999-4915/15/2… 
Influenza, mpox. - “We relate the broad-spectrum antiviral activity of repositioned molecules to their ability to disrupt virus-raft interactions, challenging the old concept that an antibiotic or anti-parasitic cannot also be an antiviral.”
“Electrostatic surface potential of an evolving peptide motif. Both ESP and the shape of the motifs are affected by amino acid changes. Blue, positive; red, negative; white, neutral.”
Among the v fascinating 2023 papers. Some scientists may be interested.
Among the v fascinating 2023 papers. Some scientists may be interested.
https://twitter.com/_ppmv/status/1618698620966154240
This is why the shift from Delta to Omicron was so significant.
https://twitter.com/_ppmv/status/1621292578736930817
Zeng 2021: “The spike protein mediates the viral cell-to-cell transmission, with an efficiency higher than that of SARS-CoV.” ACE2 not absolutely required. Alpha, Beta and WT differ in cell-free infectivity, but VOCs have similar cell-to-cell transmission. pnas.org/doi/10.1073/pn…
Send these papers to anyone who thinks SARS or HIV will somehow grow ‘mild’. They won’t.
Like all thermodynamically open systems, we and these viruses will follow the laws of thermodynamics to continue evolving.
Our real challenge is civil evolution - a question of values. 😋👻
Like all thermodynamically open systems, we and these viruses will follow the laws of thermodynamics to continue evolving.
Our real challenge is civil evolution - a question of values. 😋👻
Time to connect actions to consequences, everyone. 🙏🤗
https://twitter.com/_ppmv/status/1621605194608902144
Correct, we entered the legal phase of the pandemic …sorry endemic.
https://twitter.com/RealCheckMarker/status/1614667941747822594
Do we still have a year to save ourselves? We might! - Better make it count.
https://twitter.com/RealCheckMarker/status/1621846969227399169
Add Orf10 to the SARS-CoV-2 superpowers. Identical with SARS-CoV, iirc. onlinelibrary.wiley.com/doi/10.1002/jm…
https://twitter.com/_ppmv/status/1621829171725860865
SARS Orf10 and nucleocapsid: This shouldn’t be news.
Good luck ‘living with Covid’, if that is what you want. Going by what we know so far, it’s no good choice.
Good luck ‘living with Covid’, if that is what you want. Going by what we know so far, it’s no good choice.
https://twitter.com/_ppmv/status/1614001446365679631
Translation: any child can understand this.
https://twitter.com/_ppmv/status/1614019480971104270
Cutting community-level genetic surveillance and sequencing will make such studies impossible. It was already or will soon be cut in most states.
Demand accountability from policymakers as first step to escape the civilization-defining hubris and ignorance we face.
Good luck us
Demand accountability from policymakers as first step to escape the civilization-defining hubris and ignorance we face.
Good luck us
https://twitter.com/_ppmv/status/1621903140088848385
The real mystery to me is why we need to spend our time trying to alert people THAT there is a problem, rather than solving it. Everyone can see that denial here is no valid policy.
At some level, I bet almost everyone alive knows.
Hence the schizophrenic character of our age.
At some level, I bet almost everyone alive knows.
Hence the schizophrenic character of our age.
Happy year Four of a pandemic that should never have been allowed to start and that we could still end any day if we cared to. (Hint, it gets harder day by day.)
If this is anyone’s idea of climate mitigation, fire them and hire serious ppl instead. I’m slightly out of patience.
If this is anyone’s idea of climate mitigation, fire them and hire serious ppl instead. I’m slightly out of patience.
If you think you or your children can ‘live with’ an average of one to two SARS infections per year - currently ‘the goal’ of national policy, as some doctors who seem to have sworn a Hypocritic Oath told us, then read this thread and think hard about what it will mean for you.
https://twitter.com/realcheckmarker/status/1615898748785147905
Start the thread here if the second tweet confuses you. Sarscasm does not always translate perfectly on Twitter.
https://twitter.com/realcheckmarker/status/1615902064478937089
Thread continues here. Twitter is a mess to navigate for anyone not used to it (sorry all),
And some of the information here are viral public health content that should reach millions, rather than the few thousand who’ll read it. Sorry about that.
And some of the information here are viral public health content that should reach millions, rather than the few thousand who’ll read it. Sorry about that.
https://twitter.com/RealCheckMarker/status/1621760575591030784
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