Paul Maidowski Profile picture
Feb 5 5 tweets 3 min read
Quality advice in this thread. 🥰👇 (1) “Most die only once” (Covid acute-phase CFR will decrease); (2) “Most deadly pathogens self-eradicate” (Milder is wilder).

(2) Hence what I call the Unthinkable: pop culture - #TheLastOfUs - trained us to think extreme. Reality is subtler.
never mind the emojis or memes. This is cutting edge science, probably among humanity’s top few causes of death 👇
I have questions, because this is literally every @RealCheckMarker thread.
3. How can states end SARS?

@mvankerkhove distinguishes between (1) ending the pandemic and (2) ending the PHEIC under IHR 2005, a decision ultimately incumbent on DG Tedros in May. WHO’s hand may well be forced, but this difference could merit spelling out in public.
4. Full Q&A worth listening to; #askWHO advice on masking hospitals min 6:30. - It will take deep understanding of SARA dynamics and global health politics to end this pandemic.*

* Dr. mvankerkhove here calls ending it impossible; you see the narrative and substantive challenge.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Paul Maidowski

Paul Maidowski Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @_ppmv

Feb 6
1. mpox: human monkeypox virus (hMPXV) doesn't enter the nucleus. Genetic recombination with SARS-CoV-2 in the cytoplasm is possible in co-infected patients, eg people living with uncontrolled HIV-1 (PLH). It's the real threat of Covid Denial or Let 'er RIP policy.

#SIDU 230206 ImageImageImageImage
2. Covid can have the same effect, causing lymphopenia in perhaps 1 in 3 patients (severe #LongCOVID (#LongSARS) can be compared to HIV/AIDS).

Influenza, SARS, HIV, mpox Protein E8L follow shared evolutionary dynamics for electrostatic surface potential & co-receptor switching. ImageImageImageImage
3. Practical implication for clinicians: Test patients presenting with mpox symptoms for all three diseases.

Practical implications for all else: read science.
sciencedirect.com/science/articl…
mdpi.com/1999-4915/15/2…
mdpi.com/1420-3049/27/1…
mdpi.com/1999-4915/14/1…
Read 9 tweets
Feb 5
1. Congrats us, SARS-CoV-2 mutational fitness is steadily increasing thanks to unmitigated pandemic spread. Genuinely impressive to watch evolution happening live!

#SIDU 230205 Image
2. Direct link: For XAY.2 and XBF, click on the enlarged grey dots on the right (dis/activate search function on top or add your own). nextstrain.org/groups/neherla… Image
3. Stone Reality Check Mark if you can explain the emerging wave pattern. What we were sold as endemic is no sustainable quasi-equilibrium state.

In reality, we will see three overlapping co-circulating waves every three months, each separated by a month.
Image
Read 7 tweets
Feb 5
Did we do a vulgar thread yet? Sweat words are fantastic political language, essential power move at some times:
Brilliant thread: zero ducks given about what others think; what really bothers me is knowing what awaits those who bought into the bullshit. - Many cannot intellectually evaluate such risk themselves (no value judgement! They have other qualities), hence fall for the grifters.
Read 4 tweets
Feb 4
Fantini 2023 show electrostatic surface potential modulates spike-ganglioside interactions, to control the hemagglutination properties of coronaviruses SARS-CoV/-2, MERS-CoV and the structural dynamics of SARS-CoV-2 evolution. And HIV, influenza, #mpox. 👍 mdpi.com/1999-4915/15/2…
Influenza, mpox. - “We relate the broad-spectrum antiviral activity of repositioned molecules to their ability to disrupt virus-raft interactions, challenging the old concept that an antibiotic or anti-parasitic cannot also be an antiviral.”
“Electrostatic surface potential of an evolving peptide motif. Both ESP and the shape of the motifs are affected by amino acid changes. Blue, positive; red, negative; white, neutral.”

Among the v fascinating 2023 papers. Some scientists may be interested.
Read 20 tweets
Feb 4
Beautiful storytelling. (1) Do people know #TheLastOfUs isn't just about love and zombies? Some viral and many bacterial infections can lead to encephalitis. E patients are walking brain-dead. Happens often in hospitals.

Note masks on set: the SARS pandemic isn't over in Canada. Image
Rabies takes weeks to months to lead to encephalitis. Rapid onset would make outbreaks self-limiting. Long incubation times would allow a global zombie epidemic IF rabies acquired the immune evasion superpower of SARS-CoV-2 (Orf8).

@Neil_Druckmann stretches reality—but not much.
Read 13 tweets
Feb 3
2023 be like:

We: SARS will leave many disabled or dead, and halve human life expectancy

German Justice Minister: *celebrates ending mask mandates, the only remaining public health protection, after mutant XBB.1.5 escapes vaccines AND therapies* Image
@MarcoBuschmann, it's all public data, because it's science. Anyone who cares does or will know soon enough.

People will absolutely care once they understand they + their children are being permanently harmed, without even a fig leaf of a plan or excuse. cov-spectrum.org/explore/German… Image
@MarcoBuschmann Reminder, XBB.1.5 + mysterious pediatric hepatitis.
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(