2. Direct link: For XAY.2 and XBF, click on the enlarged grey dots on the right (dis/activate search function on top or add your own). nextstrain.org/groups/neherla…
3. Stone Reality Check Mark if you can explain the emerging wave pattern. What we were sold as endemic is no sustainable quasi-equilibrium state.
In reality, we will see three overlapping co-circulating waves every three months, each separated by a month.
Fun advice (climate/health): Always share links used to create graphs; there's always someone who doesn't know them and can learn. Even if you only communicate to peer experts.
A kind request, I'll share: dear all, if you want to see deeper analysis, ask your local scientist or politician! I'm happy to do more too, although I cannot continue to do so unpaid/as volunteer. However, here I already lean very far out the window. These are advanced questions.
1. mpox: human monkeypox virus (hMPXV) doesn't enter the nucleus. Genetic recombination with SARS-CoV-2 in the cytoplasm is possible in co-infected patients, eg people living with uncontrolled HIV-1 (PLH). It's the real threat of Covid Denial or Let 'er RIP policy.
Brilliant thread: zero ducks given about what others think; what really bothers me is knowing what awaits those who bought into the bullshit. - Many cannot intellectually evaluate such risk themselves (no value judgement! They have other qualities), hence fall for the grifters.
Quality advice in this thread. 🥰👇 (1) “Most die only once” (Covid acute-phase CFR will decrease); (2) “Most deadly pathogens self-eradicate” (Milder is wilder).
(2) Hence what I call the Unthinkable: pop culture - #TheLastOfUs - trained us to think extreme. Reality is subtler.
Fantini 2023 show electrostatic surface potential modulates spike-ganglioside interactions, to control the hemagglutination properties of coronaviruses SARS-CoV/-2, MERS-CoV and the structural dynamics of SARS-CoV-2 evolution. And HIV, influenza, #mpox. 👍 mdpi.com/1999-4915/15/2…
Influenza, mpox. - “We relate the broad-spectrum antiviral activity of repositioned molecules to their ability to disrupt virus-raft interactions, challenging the old concept that an antibiotic or anti-parasitic cannot also be an antiviral.”
“Electrostatic surface potential of an evolving peptide motif. Both ESP and the shape of the motifs are affected by amino acid changes. Blue, positive; red, negative; white, neutral.”
Among the v fascinating 2023 papers. Some scientists may be interested.
Beautiful storytelling. (1) Do people know #TheLastOfUs isn't just about love and zombies? Some viral and many bacterial infections can lead to encephalitis. E patients are walking brain-dead. Happens often in hospitals.
Note masks on set: the SARS pandemic isn't over in Canada.
Rabies takes weeks to months to lead to encephalitis. Rapid onset would make outbreaks self-limiting. Long incubation times would allow a global zombie epidemic IF rabies acquired the immune evasion superpower of SARS-CoV-2 (Orf8).
We: SARS will leave many disabled or dead, and halve human life expectancy
German Justice Minister: *celebrates ending mask mandates, the only remaining public health protection, after mutant XBB.1.5 escapes vaccines AND therapies*
@MarcoBuschmann, it's all public data, because it's science. Anyone who cares does or will know soon enough.
People will absolutely care once they understand they + their children are being permanently harmed, without even a fig leaf of a plan or excuse. cov-spectrum.org/explore/German…