Paul Maidowski Profile picture
Feb 5 7 tweets 4 min read
1. Congrats us, SARS-CoV-2 mutational fitness is steadily increasing thanks to unmitigated pandemic spread. Genuinely impressive to watch evolution happening live!

#SIDU 230205
2. Direct link: For XAY.2 and XBF, click on the enlarged grey dots on the right (dis/activate search function on top or add your own). nextstrain.org/groups/neherla…
3. Stone Reality Check Mark if you can explain the emerging wave pattern. What we were sold as endemic is no sustainable quasi-equilibrium state.

In reality, we will see three overlapping co-circulating waves every three months, each separated by a month.
4. Science is storytelling by numbers.

We excel at science, not at storytelling. Most people think the raging pandemic over!

Paper Reality Check Mark to people who can explain the following graphs: one common; I drew the rest for scientific storytellers.
Fun advice (climate/health): Always share links used to create graphs; there's always someone who doesn't know them and can learn. Even if you only communicate to peer experts.

SOMEHOW we need to learn orders of magnitude faster; this is the simplest way.
nextstrain.org/groups/neherla…
A kind request, I'll share: dear all, if you want to see deeper analysis, ask your local scientist or politician! I'm happy to do more too, although I cannot continue to do so unpaid/as volunteer. However, here I already lean very far out the window. These are advanced questions.

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More from @_ppmv

Feb 6
1. mpox: human monkeypox virus (hMPXV) doesn't enter the nucleus. Genetic recombination with SARS-CoV-2 in the cytoplasm is possible in co-infected patients, eg people living with uncontrolled HIV-1 (PLH). It's the real threat of Covid Denial or Let 'er RIP policy.

#SIDU 230206 ImageImageImageImage
2. Covid can have the same effect, causing lymphopenia in perhaps 1 in 3 patients (severe #LongCOVID (#LongSARS) can be compared to HIV/AIDS).

Influenza, SARS, HIV, mpox Protein E8L follow shared evolutionary dynamics for electrostatic surface potential & co-receptor switching. ImageImageImageImage
3. Practical implication for clinicians: Test patients presenting with mpox symptoms for all three diseases.

Practical implications for all else: read science.
sciencedirect.com/science/articl…
mdpi.com/1999-4915/15/2…
mdpi.com/1420-3049/27/1…
mdpi.com/1999-4915/14/1…
Read 9 tweets
Feb 5
Did we do a vulgar thread yet? Sweat words are fantastic political language, essential power move at some times:
Brilliant thread: zero ducks given about what others think; what really bothers me is knowing what awaits those who bought into the bullshit. - Many cannot intellectually evaluate such risk themselves (no value judgement! They have other qualities), hence fall for the grifters.
Read 4 tweets
Feb 5
Quality advice in this thread. 🥰👇 (1) “Most die only once” (Covid acute-phase CFR will decrease); (2) “Most deadly pathogens self-eradicate” (Milder is wilder).

(2) Hence what I call the Unthinkable: pop culture - #TheLastOfUs - trained us to think extreme. Reality is subtler.
never mind the emojis or memes. This is cutting edge science, probably among humanity’s top few causes of death 👇
I have questions, because this is literally every @RealCheckMarker thread.
Read 5 tweets
Feb 4
Fantini 2023 show electrostatic surface potential modulates spike-ganglioside interactions, to control the hemagglutination properties of coronaviruses SARS-CoV/-2, MERS-CoV and the structural dynamics of SARS-CoV-2 evolution. And HIV, influenza, #mpox. 👍 mdpi.com/1999-4915/15/2…
Influenza, mpox. - “We relate the broad-spectrum antiviral activity of repositioned molecules to their ability to disrupt virus-raft interactions, challenging the old concept that an antibiotic or anti-parasitic cannot also be an antiviral.”
“Electrostatic surface potential of an evolving peptide motif. Both ESP and the shape of the motifs are affected by amino acid changes. Blue, positive; red, negative; white, neutral.”

Among the v fascinating 2023 papers. Some scientists may be interested.
Read 20 tweets
Feb 4
Beautiful storytelling. (1) Do people know #TheLastOfUs isn't just about love and zombies? Some viral and many bacterial infections can lead to encephalitis. E patients are walking brain-dead. Happens often in hospitals.

Note masks on set: the SARS pandemic isn't over in Canada. Image
Rabies takes weeks to months to lead to encephalitis. Rapid onset would make outbreaks self-limiting. Long incubation times would allow a global zombie epidemic IF rabies acquired the immune evasion superpower of SARS-CoV-2 (Orf8).

@Neil_Druckmann stretches reality—but not much.
Read 13 tweets
Feb 3
2023 be like:

We: SARS will leave many disabled or dead, and halve human life expectancy

German Justice Minister: *celebrates ending mask mandates, the only remaining public health protection, after mutant XBB.1.5 escapes vaccines AND therapies* Image
@MarcoBuschmann, it's all public data, because it's science. Anyone who cares does or will know soon enough.

People will absolutely care once they understand they + their children are being permanently harmed, without even a fig leaf of a plan or excuse. cov-spectrum.org/explore/German… Image
@MarcoBuschmann Reminder, XBB.1.5 + mysterious pediatric hepatitis.
Read 10 tweets

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