#CARICAPAPAYA 🌿
Carica from the Greek “karike”, name of a fig tree. PAPAYA, derives from the Mayan "páapay-ya" which means marbled sapote (sweet-tasting fruit).
Benefits:
sciencedirect.com/science/articl…
✔️ ANTIDENGUE

hindawi.com/journals/jpr/2…
✔️Malaria

cell.com/heliyon/fullte…
✔️Antidiabetic
onlinelibrary.wiley.com/doi/10.1002/mn…
✔️Anticancerous

hindawi.com/journals/ecam/…
✔️Antioxidant, anti-inflammatory

cellbiopharm.com/ojs/index.php/…
✔️Antimicrobial
phytojournal.com/archives?year=…
✔️ Hepatoprotective, Hypolipidemic, Antiviral

mdpi.com/1420-3049/25/3…
✔️Healing
#IDEAS💡
What can a dengue patient drink?
Infusion of Carica papaya 👇 pubmed.ncbi.nlm.nih.gov/27739262/
🔴Significantly increases platelet count in patients with thrombocytopenia associated with dengue @WorldDengueDay @DrLBoominathan @Nutrients_MDPI @drakchaurasia @FrontiersIn @Harvard
🔴mdpi.com/1420-3049/27/9…
Plays a role in liver repair and normalizes coagulation by increasing platelet and white blood cell counts

🔷 C. papaya: Composition and Mechanism of action against thrombocytopenia:

🔹Carpaine:
- stimulates the ALOX-12 and PTFAR genes 👉
👉 produces megakaryocytes 👉 which mature and release more platelets
- stimulates CD110 (receptor in megakaryocytes) 👉results in high production of platelets

🔹Quercetin:
- Decreases the destruction of platelets by binding to viral proteases
🔹Ascorbic acid and beta-carotene
- Stabilize the plaque membrane
- Inhibit hemolysis
- Decreases platelet destruction

mdpi.com/2072-6643/14/8…
🔴Antithrombocytopenic effect and immunomodulatory effect
🔴frontiersin.org/articles/10.33…
Therapeutic Potential of the Leaves of Carica papaya L. during dengue fever
⬇️PLT > stimulates liver PLT formation.
- After infection of the host with dengue virus, it prevents platelet formation from stromal cells and maturation at different stages
Invading viral proteins mimic the body's platelets and are destroyed by IgM antibodies produced upon recognition of the viral proteins by the host's defense system.
Platelet and other cell aggregation mechanism in dengue virus-induced thrombocytopenia
- Thrombocytopenia processes in dengue
- Viral replication in PLT >PLT activation> add more PLT > availability. It also suppresses the bone marrow and prevents the formation of platelets by destroying premature cells.
Enhancement of platelet count through membrane stabilization and ALOX 12 gene production
- C. Papaya induces 👉 Platelet activating factor receptor (PTAFR) and arachidonate 12-lipoxygenase (ALOX-12) gene expression 👉 stimulates bone marrow to produce more megakaryocytes
- Flavonoids and antioxidants from the C. papaya leaf in the inhibition of platelet destruction
sciencedirect.com/science/articl…
C. papaya leaf juice increases PLT count in chemotherapy-induced thrombocytopenia by increasing CD110 receptor expression on megakaryocytes
ncbi.nlm.nih.gov/pmc/articles/P…
🔴Doxycycline and carica papaya are a useful modality to improve leukopenia and thrombocytopenia in patients with dengue and to minimize hospital stay.
pubmed.ncbi.nlm.nih.gov/34040647/
🔴Caution, drug interactions:
metformin, glimepiride, digoxin, ciprofloxacin, and artemisinin

pubmed.ncbi.nlm.nih.gov/27739263/

Romulo Daniel Grimaldes Jimenez, MD
Internal Medicine
February 6, 2023

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Feb 4
#IDEAS💡
1️⃣ PART

HEMORRHAGIC FEVER DUE TO #DENGUE VIRUS 🦟 MECHANISM #ADE and #MIF
pubmed.ncbi.nlm.nih.gov/36016361/
Antibody Dependent Enhancement (ADE): favorable ″bad″ antibodies for viral infections Image
pubmed.ncbi.nlm.nih.gov/33123500/
✅Intrinsic ADE: the dark side of antibody-dependent enhancement during dengue infection

The risk of severe dengue disease occurs during secondary infection with a different virus serotype than the previous infection... Image
...this occurs due to ADE= "Subneutralizing antibodies against virus particles opsonize dengue virus entry by forming complexes immune".
There are 2 types ADE
1)extrinsic ADE 👉improves virus entry
2)intrinsic ADE 👉results in increased virus production through
Read 16 tweets
Dec 27, 2022
The genes necessary for the entry of SARS-CoV-2 into human cells, ACE2 and FURIN
The repressors and activators of the ACE2 and FURIN genes were identified based on analyzes of gene overexpression and silencing experiments
🔹Repressors👉 (VDR; GATA5; SFTPC; HIF1a) and
🔹Activators👉 (HMGA2; INSIG1; RUNX1; HNF4a; JNK1/c-FOS)
■ Quercetin alters the expression of 98 of 332 (30%) human genes encoding SC2 target proteins, thereby potentially interfering with the functions of 23 of 27 (85%) of the SC2 proteins in cells human
Read 16 tweets
Dec 16, 2022
IONS IN BONE REPAIR

Bioactive glass is actually an old friend, having been developed around 50 years ago. Due to its bone growth promoting properties, it has since been often used in regenerative medicine as a bone replacement material or in dentistry. Image
Bioactive glass can be combined with biopolymers for wound treatment. This produces a flexible and transparent material for dressings for chronic wounds, such as those that can occur in patients with diabetes.
"The ions released can kill bacteria that impede healing and cause dangerous infections". Image
Read 27 tweets
Dec 6, 2022
Li👉multiple neurotransmitter signaling effects, ion transport, signaling cascades, hormonal regulation, circadian rhythm and gene expression. And multifactorial and interrelated biochemical mechanisms with various enzymes, hormones, vitamins and growth and transformation factors
Ion gradients in the🧠 can affect the concentration of nutrients in cells. To maintain these concentrations➡️K is balanced by activation of energy-dependent ion pumps = Na+/K+ ATPase (prevents accumulation of water and solute in cells,
preventing cell inflammation and loss of cytoskeletal integrity) and Ca 2 + ATPase.
mdpi.com/2075-1729/12/1… Image
Read 19 tweets
Nov 23, 2022
#FOOTBALL IS MEDICINE ⚽️🏃🏽 A biopsychosocial therapy

The idea that football can be used as therapy and as a high-intensity and literally breath-taking training regime goes back centuries. To take one prominent example, the French philosopher
Voltaire describes in the Book of Fate (1747), how a patient is cured by playing with a sacred football: “…You must kick this Bladder, Sir, once a Day about your Hall for a whole Hour together, with all the Vigour and Activity you possibly can”,
“Ogul, upon making the first Experiment, was ready to expire for want of Breath”, “In short, our Doctor in about 8 days Time, performed an absolute Cure. His Patient was as brisk, active and gay, as One in the Bloom of his Youth.”
onlinelibrary.wiley.com/doi/10.1111/sm…
Read 25 tweets
Oct 27, 2022
☑️ REUSE OF DRUGS: THE ANTIHELMINTICS #NICLOSAMIDE AND #NITAZOXANIDE ARE POTENT ANTAGONISTS OF #TMEM16A 👉 THAT COMPLETELY BRONCHODILATE THE RESPIRATORY TRACT
ncbi.nlm.nih.gov/pmc/articles/P…

☑️ The pharmacology of the TMEM16A channel: therapeutic opportunities:
The intracellular Ca-dependent Cl channel TMEM16A is a key regulator of vascular tone control and local blood flow.

°TMEM16A inhibitors have potential therapeutic uses👉 Asthma, COPD, Cystic Fibrosis, HTA/PAH, CVA, Overactive Bladder, Ca.
sciencedirect.com/science/articl…
°Pharmacological modulators👉 niflumic acid, flufenamic acid and mefenamic acid
💊 Reused 👉 Zafirlukast, Avermectins (Ivermectin), Niclosamide, Nitazoxanide, Cefarantine.
🌱Natural👉 Gallotannins, Evodiamine, Rutaecarpina, Luteolin, Galangina, Quercetin and Fisetin.
Read 25 tweets

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